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- Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes.
- Slominski AT, Kim TK, Chen J, Nguyen MN, Li W, Yates CR, Sweatman T, Janjetovic Z, Tuckey RC.SourceDepartment of Pathology and Medicine (AS), University of Tennessee HSC, Memphis, TN, USA. Electronic address: aslominski@uthsc.edu.
- The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2012 Nov;44(11):2003-18. doi: 10.1016/j.biocel.2012.07.027. Epub 2012 Aug 2.
- The discovery that 7-dehydrocholesterol (7DHC) is an excellent substrate for cytochrome P450scc (CYP11A1) opens up new possibilities in biochemistry. To elucidate its biological significance we tested ex vivo P450scc-dependent metabolism of 7DHC by tissues expressing high and low levels of P450scc a
- PMID 22877869
- Synthesis and aromatase inhibitory activity of some new 16E-arylidenosteroids.
- Bansal R, Thota S, Karkra N, Minu M, Zimmer C, Hartmann RW.SourceUniversity Institute of Pharmaceutical Sciences, Sector-14, Panjab University, Chandigarh 160 014, India. Electronic address: ranju29in@yahoo.co.in.
- Bioorganic chemistry.Bioorg Chem.2012 Sep 12;45C:36-40. doi: 10.1016/j.bioorg.2012.08.005. [Epub ahead of print]
- A new series of 16E-arylidene androstene derivatives has been synthesized and evaluated for aromatase inhibitory activity. The impact of various aryl substituents at 16 position of the steroid skeleton on aromatase inhibitory activity has been observed. The 16E-arylidenosteroids 6, 10 and 11 exhibit
- PMID 23064126
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