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cytochrome P-450 CYP1A2
cytochrome C450 1A2

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/09 16:47:39」(JST)

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  • Genetic polymorphism analysis of the drug-metabolizing enzyme CYP1A2 in a Uyghur Chinese population: a pilot study.
  • Geng T1,2,3, Zhang XY1, Wang L4, Wang H1, Shi X1, Kang L4, Hou P1, Jin T1,4.
  • Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 Jun;46(6):542-7. doi: 10.3109/00498254.2015.1089367. Epub 2015 Sep 18.
  • 1. CYP1A2 is a highly polymorphic gene and CYP1A2 enzyme results in broad inter-individual variability in response to certain pharmacotherapies, while little is known about the genetic variation of CYP1A2 in Uyghur Chinese population. The aim of the present study was to screen Uyghur volunteers fo
  • PMID 26383175
  • The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes.
  • Shi X1,2, Yang S3, Zhang G4, Song Y5, Su D5, Liu Y5, Guo F1, Shan L1,2, Cai J1.
  • Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 May;46(5):467-76. doi: 10.3109/00498254.2015.1086839. Epub 2015 Sep 15.
  • 1. The aim of this study was to investigate the inhibitory effect of morusin on Glucuronosyltransferase (UGT) isoforms and cytochrome P450 enzymes (CYP450s). We also investigated the metabolism of morusin in human, rat, dog, monkey, and minipig liver microsomes. 2. 100 μM of morusin exhibited
  • PMID 26372370
  • Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation.
  • Lassila T1,2, Mattila S1, Turpeinen M2,3, Pelkonen O2, Tolonen A4.
  • Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2016 Apr 15;30(7):917-26. doi: 10.1002/rcm.7518.
  • RATIONALE: Menthofuran is a hepatotoxin and a major metabolite of pulegone, a monoterpene found in the essential oils of many mint species. It is bioactivated by cytochrome P450 (CYP) enzymes to reactive metabolites, which may further react with glutathione to form S-linked and N-linked conjugates.
  • PMID 26969934


  • Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury
  • Li San-Qiang,Zhu Sha,Wan Xue-Dong [他]
  • The Journal of toxicological sciences : an official journal of the Japanese Society of Toxicology 39(2), 339-351, 2014-04
  • NAID 40020063625
  • Genetic polymorphism of cytochrome P450 (CYP) 1A1, CYP1A2, and CYP2E1 genes modulate susceptibility to gastric cancer in patients with Helicobacter pylori infection
  • Ghoshal Ujjala,Tripathi Shweta,Kumar Sushil [他]
  • Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 17(2), 226-234, 2014
  • NAID 40020215995
  • Effect of eurycomanone on cytochrome P450 isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in vitro
  • Pan Yan,Tiong Kai Hung,Abd-Rashid Badrul Amini [他]
  • Journal of natural medicines 68(2), 402-406, 2014
  • NAID 40020023336


CYP1A2で代謝される薬剤の例 ・テオドール・テオロング等(テオフィリン) ・メキシチール(メキシレチン塩酸塩) ・テルネリン(チザニジン) ・ジプレキサ(オランザピン) ・ゾーミッグ(ゾルミトリプタン) ・カフェインなど
CYP1A2は、全CYP中の10~15%を占め、主に肺そして肝臓に存在します。喫煙や炭火焼の食品などの摂取で、誘導を受けやすい(増えやすい)といった特徴があります。 遺伝子多型としては、通常型の *1A、低活性型の *1C、そして誘導を ...



拡張検索CYP1A2タンパク質」「チトクロムP450酵素CYP1A2」「cytochrome P-450 CYP1A2



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1マーフィー徴候 18
2narrow segment 16
3" wounds are made"  15
4グレイ症候群 15
5"phenoxypolyethoxylethanol" 15
6ロイシンエンケファリン 13
7硝酸ミコナゾール 11
8Common Laboratory Equipment 11
9content 10
10だいすいたいしんけい 9
11粟粒結核と肉下種 9
12全身性ヒマン細胞小 9
13細胞内寄生菌 9
14kligler培地 原理 9
15不整脈  9
16角膜反射 中枢 9
17膜性骨化 8
18ソルデム 8
19ハプロ不全 疾患 8
20日本多毛 8

1" wounds are made"  15
2kligler培地 原理 9
3kligler培地 硫化鉄 4
4ǸCαꥦ륹ΤǤ뤳ȤŦƤ֤Ƥ 4
5歳の女性。右目の疼痛、充血および霧視を主訴に来院した。眼底に異常を認めない。視力は右 0.9 (矯正不能)、左 1.2 (矯正不能)。眼圧は右 11 mmHg、左 12 mmHg。フルオレセイン染色後の前眼部写真 (別冊No. 5) を別に示す。 治療薬として適切なのはどれか。 4
6胃癌 borrmann分類 3
7回復過程 3
8ジェンドラシック法 メカニズム 3
9しょうすいたいしんけい 3
10ラリンゲルマスク ゼリー 3
11ハッセルバッハ三角 3
12白内障 grade 3
13フォンギールケ病 3
14マッコーネルサイン 3
15小児骨折 好発部位 3
16咽頭神経叢 3
17低アルドステロン症 3
18フロマン徴候 3
19オーグメンチン 販売中止 3
20クスマウル徴候 3