CSL

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/01 12:50:41」(JST)

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英文文献

  • Obesity induced a leptin-Notch signaling axis in breast cancer.
  • Battle M1, Gillespie C, Quarshie A, Lanier V, Harmon T, Wilson K, Torroella-Kouri M, Gonzalez-Perez RR.Author information 1Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA.AbstractTo investigate whether obesity induces a leptin-Notch signaling axis in breast cancer (BC), leptin-induced Notch was determined in human MCF-7 and MDA-MB231 and mouse E0771 cells and in E0771-BC hosted by syngeneic lean and diet-induced obesity (DIO) C57BL/6J female mice. Lean and DIO mice were treated for 3 weeks with leptin inhibitor (PEG-LPrA2) 1 week after the inoculation of E0771 cells. Leptin induced Notch1, 3 and 4 in BC cells, but Notch2 expression showed opposite pattern in MCF-7 compared to MDA-MB231 cells. Notch loss-of-function (DAPT and dominant negative [R218H] RBP-Jk [CSL/CBF1]) showed that a functional leptin-Notch signaling axis was involved in the proliferation and migration of E0771 cells. E0771-BC onset was affected by obesity (lean mice7/10 [70%] vs. DIO mice: 11/12 [92%]; Pearson χ(2) : p = 0.06]). PEG-LPrA2 significantly reduced BC growth (untreated: 19/42; [45%] vs. treated: 8/42 [19%]; Pearson χ(2) : p = 0.008). PEG-LPrA2 did not influence the caloric intake of mice but increased carcass and/or body weights of lean and DIO mice inoculated with E0771 cells, which could be related to the improvement of health conditions (less aggressive disease). Importantly, BC from obese mice had higher levels of Notch3, JAG1 and survivin than lean mice. Inhibition of leptin signaling reduced protein levels of Notch (NICD1, NICD4, Notch3, JAG1 and survivin) and significantly decreased mRNA expression of Notch receptors, ligands and targets. PEG-LPrA's effects were more prominent in DIO mice. Present data suggest that leptin induces Notch, which could be involved in the reported higher incidence and aggressiveness and, poor prognosis of BC in obese patients.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2014 Apr 1;134(7):1605-16. doi: 10.1002/ijc.28496. Epub 2013 Oct 8.
  • To investigate whether obesity induces a leptin-Notch signaling axis in breast cancer (BC), leptin-induced Notch was determined in human MCF-7 and MDA-MB231 and mouse E0771 cells and in E0771-BC hosted by syngeneic lean and diet-induced obesity (DIO) C57BL/6J female mice. Lean and DIO mice were trea
  • PMID 24114531
  • The Ca(2+)-dependent interaction of calpastatin domain L with the C-terminal tail of the Cav1.2 channel.
  • Sun W1, Feng R2, Hu H2, Guo F2, Gao Q2, Shao D1, Yin D1, Wang H1, Sun X2, Zhao M2, Minobe E3, Sun Y4, Jiao G5, Kameyama M3, Hao L6.Author information 1Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110001, China.2Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110001, China; Cardiovascular Institute of China Medical University, Shenyang 110001, China.3Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.4Cardiovascular Institute of China Medical University, Shenyang 110001, China.5Respiratory Department and Intensive Care Unit, Shengjing Hospital of China Medical University, Shenyang 110004, China.6Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110001, China; Cardiovascular Institute of China Medical University, Shenyang 110001, China. Electronic address: lyhao@mail.cmu.edu.cn.AbstractTo demonstrate the interaction of calpastatin (CS) domain L (CSL) with Cav1.2 channel, we investigated the binding of CSL with various C-terminus-derived peptides at≈free, 100nM, 10μM, and 1mM Ca(2+) by using the GST pull-down assay method. Besides binding with the IQ motif, CSL was also found to bind with the PreIQ motif. With increasing [Ca(2+)], the affinity of the CSL-IQ interaction gradually decreased, and the affinity of the CSL-PreIQ binding gradually increased. The results suggest that CSL may bind with both the IQ and PreIQ motifs of the Cav1.2 channel in different Ca(2+)-dependent manners.
  • FEBS letters.FEBS Lett.2014 Mar 3;588(5):665-71. doi: 10.1016/j.febslet.2014.01.019. Epub 2014 Jan 23.
  • To demonstrate the interaction of calpastatin (CS) domain L (CSL) with Cav1.2 channel, we investigated the binding of CSL with various C-terminus-derived peptides at≈free, 100nM, 10μM, and 1mM Ca(2+) by using the GST pull-down assay method. Besides binding with the IQ motif, CSL was also found to
  • PMID 24462690

和文文献

  • 規格・標準化報告 "JIS Z 8835 一面せん断試験による限界状態線(CSL)および壁面崩壊線(WYL)の測定方法"の紹介 : 特に、APPIE規格をJIS規格にする段階で議論になった点について
  • 22aBS-1 サイバー空間中での口コミブームの解析とモデル化

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関連記事C」「CS

C」

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WordNet   license wordnet

「the 3rd letter of the Roman alphabet」
c

WordNet   license wordnet

「(music) the keynote of the scale of C major」

WordNet   license wordnet

「a general-purpose programing language closely associated with the UNIX operating system」

PrepTutorEJDIC   license prepejdic

「carbonの化学記号」

CS」

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