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不意に一激 / 大当たり,大成功 / =coup d'etat
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/14 12:32:36」(JST)

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COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.^[1]^[2] The COUP acronym stands for chicken ovalbumin upstream promoter.

Function

COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.^[3]^[4]

The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity.^[5]^[6] COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.^[7]

Interactions

COUP-TFII has been shown to interact with:

HDAC1^[8]
Lck^[9]
V-erbA-related gene.^[10]
Nucleolin^[11]

References

^ "Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2".
^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (September 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
^ Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (April 1999). "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development". Genes Dev. 13 (8): 1037–49. doi:10.1101/gad.13.8.1037. PMC 316637. PMID 10215630.
^ Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY (December 2004). "The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development". Mol. Cell. Biol. 24 (24): 10835–43. doi:10.1128/MCB.24.24.10835-10843.2004. PMC 533959. PMID 15572686.
^ De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (April 2004). "The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism". Mol. Endocrinol. 18 (4): 820–33. doi:10.1210/me.2003-0341. PMID 14739255.
^ De Martino MU, Alesci S, Chrousos GP, Kino T (June 2004). "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism". Ann. N. Y. Acad. Sci. 1024: 72–85. doi:10.1196/annals.1321.006. PMID 15265774.
^ Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (February 2008). "The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis". Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421–6. doi:10.1073/pnas.0707082105. PMC 2268152. PMID 18250317.
^ Smirnov DA, Hou S, Ricciardi RP (March 2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology 268 (2): 319–28. doi:10.1006/viro.1999.0181. PMID 10704340.
^ Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (November 1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200. doi:10.1074/jbc.271.44.27197. PMID 8910285.
^ Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). "Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
^ Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM Jr, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM. (May 2012). "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.". PLoS One 7 (5). doi:10.1371/journal.pone.0038278. PMC 3365040. PMID 22693611.

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English Journal

Choose your destiny: Make a cell fate decision with COUP-TFII.

Wu SP1, Yu CT2, Tsai SY3, Tsai MJ4.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Mar;157:7-12. doi: 10.1016/j.jsbmb.2015.11.011. Epub 2015 Dec 2.
Cell fate specification is a critical process to generate cells with a wide range of characteristics from stem and progenitor cells. Emerging evidence demonstrates that the orphan nuclear receptor COUP-TFII serves as a key regulator in determining the cell identity during embryonic development. The
PMID 26658017

MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer.

Wang L1, Xu M1, Qin J2, Lin SC1, Lee HJ1, Tsai SY1, Tsai MJ1.
Oncotarget.Oncotarget.2016 Feb 15. doi: 10.18632/oncotarget.7405. [Epub ahead of print]
Mitochondrial pyruvate carrier 1 (MPC1) and MPC 2 form a transporter complex in cells to control pyruvate transportation into mitochondria. Reduced expression of MPC1 disrupts the transporter function, induces metabolic shift to increase glycolysis, and thus plays important roles in several diseases
PMID 26895100

KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 Leydig cells.

Tremblay MA1, Mendoza-Villarroel RE2, Robert NM3, Bergeron F4, Tremblay JJ5.
Journal of molecular endocrinology.J Mol Endocrinol.2016 Feb 12. pii: JME-15-0139. [Epub ahead of print]
Insulin-like 3 (INSL3), a Leydig cell-specific hormone, is essential for testis descent during fetal life and bone metabolism in adults. Despite its essential roles in male reproductive and bone health, very little is known regarding its transcriptional regulation in Leydig cells. To date, few trans
PMID 26874000

Japanese Journal

Roles of transcriptional network during the formation of lymphatic vessels

Watabe Tetsuro
The journal of biochemistry 152(3), 213-220, 2012-09-01
NAID 10031166132

Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues

Demura Masashi,Wang Fen,Yoneda Takashi,Karashima Shigehiro,Mori Shunsuke,Oe Masashi,Kometani Mitsuhiro,Sawamura Toshitaka,Cheng Yuan,Maeda Yuji,Namiki Mikio,Ino Hidekazu,Fujino Noboru,Uchiyama Katsuharu,Tsubokawa Toshinari,Yamagishi Masakazu,Nakamura Yasuhiro,Ono Katsuhiko,Sasano Hironobu,Demura Yoshiki,Takeda Yoshiyu
Journal of Hypertension 29(6), 1185-1195, 2011-06
… Nuclear receptor families NR4A [nerve growth factor-induced clone B (NGFIB), Nur-related factor 1 (NURR1) and neuron-derived orphan receptor 1 (NOR1)] and NR2F [chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TFI), COUP-TFII and NR2F6) activate, whereas NR5A1 [steroidogenic factor 1 (SF1)] represses CYP11B2 (aldosterone synthase) gene transcription. …
NAID 120003141563

A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene

KONOSHITA Tadashi,FUCHS Sébastien,MAKINO Yasukazu,WAKAHARA Shigeyuki,MIYAMORI Isamu
Journal of cellular biochemistry 102(4), 1043-1050, 2007-11
… The human renin gene contains a direct repeat (DR) motifAGGGGTCAC-AGGGCCA in the proximal region (-259/-245 bp), which contains similar sequence for nuclear receptor superfamily binding core motif, AGGTCA, and is the most similar to COUP-TFII consensus. … One of the binding proteins was strongly suspected to be COUP-TFII-consensus-specific by EMSA. …
NAID 120001008431

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★リンクテーブル★

リンク元	「COUP転写因子II」「COUP transcription factor II」
関連記事	「TF」「CO」

「COUP転写因子II」

Nuclear receptor subfamily 2, group F, member 2
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	3CJW
Identifiers
Symbols	NR2F2 ; ARP1; COUPTFB; COUPTFII; NF-E3; NR2F1; SVP40; TFCOUP2
External IDs	OMIM: 107773 MGI: 1352452 HomoloGene: 7628 IUPHAR: NR2F2 GeneCards: NR2F2 Gene
Gene Ontology
Molecular function	• retinoic acid binding; • sequence-specific DNA binding transcription factor activity; • steroid hormone receptor activity; • transcription corepressor activity; • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; • protein binding; • zinc ion binding; • protein homodimerization activity; • sequence-specific DNA binding;
Cellular component	• nucleus;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • neuron migration; • maternal placenta development; • negative regulation of endothelial cell proliferation; • regulation of transcription from RNA polymerase II promoter; • lipid metabolic process; • signal transduction; • skeletal muscle tissue development; • fertilization; • anterior/posterior pattern specification; • radial pattern formation; • negative regulation of endothelial cell migration; • intracellular receptor signaling pathway; • forebrain development; • response to estradiol stimulus; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of transcription, DNA-dependent; • positive regulation of transcription, DNA-dependent; • blood vessel morphogenesis; • limb development; • placenta blood vessel development; • trophoblast giant cell differentiation; • regulation of transcription involved in lymphatic endothelial cell fate commitment;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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