WordNet

an impairment of health or a condition of abnormal functioning
the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
of or relating to the immune response of the body against substance normally present in the body

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1. 小児における中枢神経系の急性脱髄の鑑別診断 differential diagnosis of acute central nervous system demyelination in children
2. 自己免疫の概要 overview of autoimmunity
3. 慢性炎症性脱髄性多発神経炎：病因、臨床的特徴、および診断 chronic inflammatory demyelinating polyneuropathy etiology clinical features and diagnosis
4. 免疫誘導性神経障害 immune mediated neuropathies
5. 小児多発性硬化症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of pediatric multiple sclerosis

Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation.

Rothhammer V1, Kenison JE1, Tjon E1, Takenaka MC1, de Lima KA1, Borucki DM1, Chao CC1, Wilz A1, Blain M2, Healy L2, Antel J2, Quintana FJ3,4.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2017 Feb 6. pii: 201615413. doi: 10.1073/pnas.1615413114. [Epub ahead of print]
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the CNS that causes disability in young adults as a result of the irreversible accumulation of neurological deficits. Although there are potent disease-modifying agents for its initial relapsing-remitting phase, these the
PMID 28167760

Neutrophil perversion in demyelinating autoimmune diseases: Mechanisms to medicine.

Casserly CS1, Nantes JC2, Whittaker Hawkins RF3, Vallières L4.
Autoimmunity reviews.Autoimmun Rev.2017 Feb 2. pii: S1568-9972(17)30026-5. doi: 10.1016/j.autrev.2017.01.013. [Epub ahead of print]
Neutrophils are essential to a healthy life, yet pose a threat if improperly controlled. Neutrophil perversion is well documented in a variety of inflammatory disorders (e.g. arthritis, lupus, psoriasis), but is only beginning to be demystified in autoimmune demyelination, the most common cause of n
PMID 28161558

The Association of Interleukin-16 Gene Polymorphisms with IL-16 Serum Levels and Risk of Multiple Sclerosis.

Farrokhi M1,2, Masoudifar A3, Derakhshan A4, Saadatmand S5, Rouhi-Boroujeni H4, Etemadifar M6, Rezaei-Zarji S5, Javid A5, Nobakht R7, Deyhimi M7, Ekramnia A7, Ebrahimi M8, Sheikh S9, Ansaripour S4, Amani-Beni A7, Jahanbani-Ardakani H7.
Immunological investigations.Immunol Invest.2017 Feb 2:1-9. doi: 10.1080/08820139.2016.1268154. [Epub ahead of print]
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) that is immunologically mediated in genetically susceptible individuals. Interleukin-16 (IL-16), a pleiotropic cytokine, is an important regulator of T-cell
PMID 28151028