CDCA

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ケノデオキシコール酸 chenodeoxycholic acid

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/24 12:32:57」(JST)

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英文文献

  • Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: Role of glycine conjugates.
  • Chatterjee S1, Bijsmans IT2, van Mil SW3, Augustijns P4, Annaert P5.Author information 1KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Sagnik.Chatterjee@pharm.kuleuven.be.2Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: i.bijsmans@umcutrecht.nl.3Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: s.w.c.vanmil@umcutrecht.nl.4KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Patrick.Augustijns@pharm.kuleuven.be.5KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Pieter.Annaert@pharm.kuleuven.be.AbstractExcessive intrahepatic accumulation of bile acids (BAs) is a key mechanism underlying cholestasis. The aim of this study was to quantitatively explore the relationship between cytotoxicity of BAs and their intracellular accumulation in sandwich-cultured rat hepatocytes (SCRH). Following exposure of SCRH (on day-1 after seeding) to various BAs for 24h, glycine-conjugated BAs were most potent in exerting toxicity. Moreover, unconjugated BAs showed significantly higher toxicity in day-1 compared to day-3 SCRH. When day-1/-3 SCRH were exposed (0.5-4h) to 5-100μM (C)DCA, intracellular levels of unconjugated (C)DCA were similar, while intracellular levels of glycine conjugates were up to 4-fold lower in day-3 compared to day-1 SCRH. Sinusoidal efflux was by far the predominant efflux pathway of conjugated BAs both in day-1 and day-3 SCRH, while canalicular BA efflux showed substantial interbatch variability. After 4h exposure to (C)DCA, intracellular glycine conjugate levels were at least 10-fold higher than taurine conjugate levels. Taken together, reduced BA conjugate formation in day-3 SCRH results in lower intracellular glycine conjugate concentrations, explaining decreased toxicity of (C)DCA in day-3 versus day-1 SCRH. Our data provide for the first time a direct link between BA toxicity and glycine conjugate exposure in SCRH.
  • Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2014 Mar;28(2):218-30. doi: 10.1016/j.tiv.2013.10.020. Epub 2013 Nov 7.
  • Excessive intrahepatic accumulation of bile acids (BAs) is a key mechanism underlying cholestasis. The aim of this study was to quantitatively explore the relationship between cytotoxicity of BAs and their intracellular accumulation in sandwich-cultured rat hepatocytes (SCRH). Following exposure of
  • PMID 24211540
  • Tandem mass spectrometric characterization of bile acids and steroid conjugates based on low-energy collision-induced dissociation.
  • Maekawa M1, Shimada M1, Iida T2, Goto J1, Mano N3.Author information 1Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.2Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajousui, Setagaya-ku, Tokyo 156-8550, Japan.3Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Electronic address: mano@hosp.tohoku.ac.jp.AbstractWe examined the characteristics of several bile acids and some steroid conjugates under low-energy-collision-induced dissociation conditions using a triple quadrupole tandem mass spectrometer. According to conjugation types, we observed characteristic product ions and/or neutral losses in the product ion spectra. Amino acid conjugates afforded specific product ions. For example, glycine-conjugated metabolites routinely produced a product ion at m/z 74, and taurine-conjugated metabolites produced product ions at m/z 124, 107, and 80. When a strong peak appeared at m/z 97, the molecule contained a sulfate group. In contrast to amino acid conjugates, carbohydrate conjugates required a combination of product ions and neutral losses for identification. We could discriminate a glucoside from an acyl galactoside according to the presence or absence of a product ion at m/z 161 and a neutral loss of 180Da. Discrimination among esters, aliphatic ethers, and phenolic ether types of glucuronides was based upon differences in the intensities of a product ion at m/z 175 and a neutral loss of 176Da. Furthermore, N-acetylglucosamine conjugates showed a characteristic product ion at m/z 202 and a neutral loss of 203Da, and the appearance of a product ion at m/z 202 revealed the existence of N-acetylglucosamine conjugated to an aliphatic hydroxyl group without a double bond in the immediate vicinity. Together, the data presented here will help to enable the identification of unknown conjugated cholesterol metabolites by using low-energy collision-induced dissociation.
  • Steroids.Steroids.2014 Feb;80:80-91. doi: 10.1016/j.steroids.2013.11.016. Epub 2013 Dec 1.
  • We examined the characteristics of several bile acids and some steroid conjugates under low-energy-collision-induced dissociation conditions using a triple quadrupole tandem mass spectrometer. According to conjugation types, we observed characteristic product ions and/or neutral losses in the produc
  • PMID 24296272
  • A Possible Role of Chenodeoxycholic Acid and Glycine-Conjugated Bile Acids in Fibrotic Steatohepatitis in a Dietary Rat Model.
  • Jia X, Suzuki Y, Naito H, Yetti H, Kitamori K, Hayashi Y, Kaneko R, Nomura M, Yamori Y, Zaitsu K, Kato M, Ishii A, Nakajima T.Author information Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.AbstractBACKGROUND AND AIMS: Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive 5/Dmcr rats, based on dysregulated BA homeostasis pathways. We aimed to further characterize BA profiles in liver and evaluate their relationships to liver injury using this model.
  • Digestive diseases and sciences.Dig Dis Sci.2014 Jan 22. [Epub ahead of print]
  • BACKGROUND AND AIMS: Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive 5/Dmcr rats, based on dysregulated BA homeostasis pathwa
  • PMID 24448653

和文文献

  • 日本人成人におけるピレスロイド殺虫剤代謝物のバイオモニタリング
  • 上山 純,野村 洸司,斎藤 勲,近藤 高明,杉浦 友香,村田 勝敬,岩田 豊人,涌澤 伸哉,上島 通浩
  • 日本毒性学会学術年会 40.1(0), 1002019, 2013
  • … 合成ピレスロイド系殺虫剤(PYR)は農業用あるいは家庭用殺虫剤として日本人にも馴染のある化学物質であるが,PYR曝露マーカーである尿中クリサンテマムジカルボン酸(CDCA)および3フェノキシ安息香酸(3PBA)排泄量に関する日本人のデータは少ない。 … 本研究では日本人成人の尿中に排泄されるCDCAおよび3PBA量をモニタリングし,それらの季節変動,職域間差および曝露源について検討した。 …
  • NAID 130004676499
  • Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest
  • Uchida Fumihiko,Uzawa Katsuhiro,Kasamatsu Atsushi,Takatori Hiroaki,Sakamoto Yosuke,Ogawara Katsunori,Shiiba Masashi,Tanzawa Hideki,Bukawa Hiroki
  • BMC cancer 12, 321, 2012-07
  • … BackgroundCell division cycle associated 3 (CDCA3), part of the Skp1-cullin-F-box (SCF) ubiquitin ligase, refers to a trigger of mitotic entry and mediates destruction of the mitosis inhibitory kinase. … Little is known about the relevance of CDCA3 to human malignancy including oral squamous cell carcinoma (OSCC). …
  • NAID 120004898305
  • 多発性巨大軟部腫瘤を認めた脳腱黄色腫症の1例
  • 梅本 勇基,上野 弘貴,原 直之 [他],中村 毅,大槻 俊輔,柳瀬 哲至,山脇 健盛,松本 昌泰
  • 日本内科学会雑誌 101(5), 1397-1400, 2012-05-10
  • … 脳腱黄色腫症(cerebrotendinous xanthomatosis:CTX)は知能低下,小脳失調,白内障,腱黄色腫を呈する遺伝性代謝疾患である.本例は53歳,女性.四肢に巨大な軟部腫瘤を認め生検により黄色腫と判明.小脳歯状核病変や血清コレスタノール高値からCTXと診断しケノデオキシコール酸(chenodeoxycholic acid:CDCA)とスタチンの投与を開始した.下腿の巨大黄色腫はMRIでT2WI高信号域を認め出血や粘液変性の存在が示唆された. …
  • NAID 10031130551

関連リンク

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During the 2014 CDCA Board Meeting, it was determined that a feasibility study should be performed regarding the creation of a U.S. domestic registry for desert bred Canaan Dogs and their offspring. This registry could be modeled ...

関連画像

CDCA inicia novas turmas do programa Jovem CDCA Toulouse 1994, Comité de Défense CDCA fecha parceria com UNIS e inicia novo  CDCA e pais e responsáveis dos alunos daBOOT 199+ ++++ ++++ ++++ (CDCA).jpgFala Varginha: CDCA PROMOVE PRIMEIRO


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