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English Journal

Ganoderma lucidum polysaccharides encapsulated in liposome as an adjuvant to promote Th1-bias immune response.

Liu Z1, Xing J1, Zheng S1, Bo R1, Luo L1, Huang Y1, Niu Y1, Li Z1, Wang D2, Hu Y1, Liu J1, Wu Y1.
Carbohydrate polymers.Carbohydr Polym.2016 May 20;142:141-8. doi: 10.1016/j.carbpol.2016.01.021. Epub 2016 Jan 12.
Liposome-based vaccine delivery systems are known to enhance immune responses. Ganoderma lucidum polysaccharides (GLP) have been widely studied as immunomodulator and it could be as inducers of strong immune responses. In the research, GLP and ovalbumin (OVA) were encapsulated into liposome as vacci
PMID 26917384

Characterization of age-associated exhausted CD8(+) T cells defined by increased expression of Tim-3 and PD-1.

Lee KA1, Shin KS1, Kim GY2, Song YC1, Bae EA2, Kim IK1, Koh CH1, Kang CY1,2.
Aging cell.Aging Cell.2016 Apr;15(2):291-300. doi: 10.1111/acel.12435. Epub 2016 Jan 10.
Aging is accompanied by altered T-cell responses that result in susceptibility to various diseases. Previous findings on the increased expression of inhibitory receptors, such as programmed cell death protein 1 (PD-1), in the T cells of aged mice emphasize the importance of investigations into the r
PMID 26750587

Viral-mimicking protein nanoparticle vaccine for eliciting anti-tumor responses.

Molino NM1, Neek M1, Tucker JA2, Nelson EL3, Wang SW4.
Biomaterials.Biomaterials.2016 Apr;86:83-91. doi: 10.1016/j.biomaterials.2016.01.056. Epub 2016 Feb 1.
The immune system is a powerful resource for the eradication of cancer, but to overcome the low immunogenicity of tumor cells, a sufficiently strong CD8(+) T cell-mediated adaptive immune response is required. Nanoparticulate biomaterials represent a potentially effective delivery system for cancer
PMID 26894870