CD45

出典: meddic

leukocyte common antigen LCA, T200, B220
CD45RO, CD45RA, CD45RB
表面抗原分類

発現細胞

  • 全ての造血細胞

分子量

  • 180-240 kDa

機能

  • tyrosine phosphatase, augments sinnaling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing

ファミリー

  • fibronectin type III


疾患との関連




Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/03/18 14:02:38」(JST)

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英文文献

  • Adipose tissue-derived stem cells embedded with eNOS restore cardiac function in acute myocardial infarction model.
  • Shi CZ, Zhang XP, Lv ZW, Zhang HL, Xu JZ, Yin ZF, Yan YQ, Wang CQ.SourceDepartment of Cardiology, the Ninth Hospital Affiliated to Medical College, Shanghai Jiaotong University, ShangHai, China.
  • International journal of cardiology.Int J Cardiol.2012 Jan 12;154(1):2-8.
  • This study assessed the potential therapeutic efficacy of endothelial NO syntheses (eNOS)-expressing adipose tissue-derived stem cells (ADSCs) on infarcted hearts. We isolated CD29+, CD44+, CD45- cells from adipose tissue. Multipotent property of ADSCs was characterized by induction to differentiate
  • PMID 21640405
  • Solid-state capture and real-time analysis of individual T cell activation via self-assembly of binding multimeric proteins on functionalized materials surfaces.
  • Diener KR, Christo SN, Griesser SS, Sarvestani GT, Vasilev K, Griesser HJ, Hayball JD.SourceHanson Institute, Adelaide, SA 5000, Australia; School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia.
  • Acta biomaterialia.Acta Biomater.2012 Jan;8(1):99-107. Epub 2011 Sep 6.
  • Polyfunctional T cell responses are increasingly underpinning new and improved vaccination regimens. Studies of the nature and extent of these T cell responses may be facilitated if specific T cell populations can be assessed from mixed populations by ligand-mediated capture in a solid-state assay f
  • PMID 21945827
  • Neutrophil phenotypic characteristics in children with congenital asplenia and splenectomized for hereditary spherocytosis.
  • Mikoluc B, Michalkiewicz J, Motkowski R, Smolka D, Pietrucha B, Piotrowska-Jastrzebska J, Bernatowska E.SourceDepartment of Pediatrics and Developmental Disorders of Children and Adolescents Medical University of Bialystok, Waszyngtona str 17 , 15-224 Bialystok , Poland.
  • Immunological investigations.Immunol Invest.2012;41(1):61-74. Epub 2011 Aug 30.
  • The spleen plays an important role in the granulocyte homeostasis due to such mechanisms as pooling, elimination of senescent cells and regulatory effects on granulocyte renewal in the bone marrow. The expression profile of granulocyte receptors was tested in children with congenital asplenia, and s
  • PMID 21877936

和文文献

  • Frequency of CD45RO+ subset in CD4+CD25high regulatory T cells associated with progression of hepatocellular carcinoma
  • Takata Yoshiko,Nakamoto Yasunari,Nakada Akiko,Terashima Takeshi,Arihara Fumitaka,Kitahara Masaaki,Kakinoki Kaheita,Arai Kuniaki,Yamashita Taro,Sakai Yoshio,Yamashita Tatsuya,Mizukoshi Eishiro,Kaneko Shuichi
  • Cancer Letters 307(2), 165-173, 2011-08-28
  • … In HCC patients, the prevalence of CD45RO+ cells in CD4+CD25high T cells was increased and associated with higher frequencies of plasmacytoid DCs. … These results suggest that increased frequencies of the CD45RO+ subset in CD4+CD25high Tregs in HCC patients may establish the immunosuppressive environment cooperatively with tolerogenic plasmacytoid DCs to promote disease progression of liver cancer. …
  • NAID 120003141809
  • Involvement of bone-marrow-derived cells in kidney fibrosis
  • Wada Takashi,Sakai Norihiko,Sakai Yoshio,Matsushima Kouji,Kaneko Shuichi,Furuichi Kengo
  • Clinical and Experimental Nephrology 15(1), 8-13, 2011-02
  • … Bone-marrow-derived cells positive for CD45 or CD34, and type 1 (pro)collagen dependent on the chemokine and renin-angiotensin systems migrate into diseased kidneys and enhance synthesis matrix protein, cytokines/chemokines, and profibrotic growth factors, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating kidney fibrosis. …
  • NAID 120002851394
  • Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression
  • Yamasaki Shoutarou,Nobuhisa Ikuo,Ramadan Ahmed [他]
  • Development, growth & differentiation 53(7), 870-877, 2011-09
  • NAID 40019016840

関連リンク

CD45分子は単鎖膜貫通タンパクで、分子量180~220kDaの範囲で少なくとも5つの アイソフォームがあります。これらのアイソフォームは遺伝子配列上の3つのエクソン(A, B,C)の選択的スプライシングによる組み合わせから形成されます。すべてのCD45 ...
CD45抗体はヒトCD45抗原を認識します。このCD45抗原は、白血球共通抗原 ( Leukocyte common antigen (LCA)) としても知られている、チロシンホスファターゼ です。CD45は赤血球、血小板およびそれらの前駆細胞を除いた全てのヒト造血系由来 の細胞に ...

関連画像

Alexander, DR. (2000). The CD45 tyrosine CD45 expression unmask functions for CD45 図6 CD45の発現量の違いによる free picsgirls tied spreadeagle to bedCD45Antigeni Cd45 www.lookfordiagnosis.com www Immunohistochemistry-Paraffin: CD45 CD45 (Leucocyte Common Antigen)


★リンクテーブル★
リンク元悪性リンパ腫」「表面抗原分類」「LCA」「記憶T細胞
拡張検索CD45RO」「CD45RA」「CD45R」「CD45欠損症」「CD45RB
関連記事CD」「CD4

悪性リンパ腫」

  [★]

malignant lymphoma
lymphoma malignum

悪性リンパ腫とマーカー

悪性リンパ腫.xls
  sIg CD5 CD10 CD19 CD20 CD23 CD43 bcl cyclin TdT その他 転座
小リンパ性リンパ腫 small lymphocytic lymphoma
慢性リンパ性白血病 chronic lymphocytic leukemia
       
濾胞性リンパ腫 FL
 
      bcl2 +      
MALTリンパ腫
 
                 
マントル細胞リンパ腫 MCL
 
             
びまん性大細胞性B細胞リンパ腫 DLBL
 
+/-     bcl6 +        
前駆Bリンパ芽球性リンパ腫
急性Bリンパ球性白血病 LBL/ALL
                 
バーキットリンパ腫 BL
 
          Myc, Ki-67 t(8,14)Myc;IgH ~80%
t(2,8)κ;Myc ~15%
ホジキンリンパ腫
 
                    CD15, CD30, CD45 - t(8,22)Myc;λ ~10%
成人T細胞白血病 ATL
 
                    CD2, CD3, CD4, CD25, HLA-DR, CD8 -  

病期

参考

  • 1.
http://www.rinpashu.com/inspection/

国試




表面抗原分類」

  [★]

cluster of differentiation, CD
  • 細胞の表面抗原を認識する抗体を整理した分類
Bリンパ球 CD10,CD19,CD20
Tリンパ球 CD2,CD3,CD5,CD7
幹細胞 CD34
顆粒球 CD13,CD33
単球 CD14:LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。
巨核球 CD41(GpIIb),CD42(GpIb)
NK細胞CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)


CD1 CD21 CD41 CD61 CD81
CD2 CD22 CD42 CD62 CD82
CD3 CD23 CD43 CD63 CD83
CD4 CD24 CD44 CD64 CD84
CD5 CD25 CD45 CD65 CD85
CD6 CD26 CD46 CD66 CD86
CD7 CD27 CD47 CD67 CD87
CD8 CD28 CD48 CD68 CD88
CD9 CD29 CD49 CD69 CD89
CD10 CD30 CD50 CD70 CD90
CD11 CD31 CD51 CD71 CD91
CD12 CD32 CD52 CD72 CD92
CD13 CD33 CD53 CD73 CD93
CD14 CD34 CD54 CD74 CD94
CD15 CD35 CD55 CD75 CD95
CD16 CD36 CD56 CD76 CD96
CD17 CD37 CD57 CD77 CD97
CD18 CD38 CD58 CD78 CD98
CD19 CD39 CD59 CD79 CD99
CD20 CD40 CD60 CD80 CD100


LCA」

  [★]


記憶T細胞」

  [★]

memory T cell, memory T-cell
メモリーT細胞
T細胞

CD45RO」

  [★]

CD45, CD45RA, CD45RB
表面抗原分類

発現細胞

分子量

  • 180

機能

  • isoform of CD45 containing the A, B, and C exons

ファミリー

  • fibronectin type II

発現の強度

  • 記憶T細胞では強く発現するので、マーカーとして使われる。
  naive T cell effector T cell memory T cell
CD45RO +++ +++
CD45RA +++ +++



CD45RA」

  [★]

CD45, CD45RB, CD45RO
表面抗原分類

発現細胞

  • B細胞、T細胞サブセット(naive T cells), 単球

分子量

  • 205-220

機能

  • isoform of CD45 containing the A exon

ファミリー

  • fibronectin type II


CD45R」

  [★]

B220CD50??
表面抗原分類


CD45欠損症」

  [★]

CD45 deficiency
CD45


CD45RB」

  [★]

表面抗原分類


CD」

  [★]

PrepTutorEJDIC   license prepejdic

「certificate of deposit / (また『C.D.』)Civil Defense民間防衛」


CD4」

  [★]

T4, Leucine-SA, Leucine-3B
表面抗原分類



"http://meddic.jp/CD45" より作成


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