CD239

同

B-cell adhesion molecule, Lutheran blood group

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/01 12:51:44」(JST)

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Basal cell adhesion molecule (Lutheran blood group)
Rendering based on PDB 2PET​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2PET​, 2PF6​
Identifiers
Symbols	BCAM ; AU; CD239; LU; MSK19
External IDs	OMIM: 612773 MGI: 1929940 HomoloGene: 21149 GeneCards: BCAM Gene
Gene ontology Molecular function • transmembrane signaling receptor activity • laminin receptor activity • protein binding • protein C-terminus binding • laminin binding Cellular component • plasma membrane • integral component of plasma membrane • external side of plasma membrane • extracellular exosome Biological process • cell adhesion • cell-matrix adhesion • signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4059	57278
Ensembl	ENSG00000187244	ENSMUSG00000002980
UniProt	P50895	Q9R069
RefSeq (mRNA)	NM_001013257	NM_020486
RefSeq (protein)	NP_001013275	NP_065232
Location (UCSC)	Chr 19: 44.81 – 44.82 Mb	Chr 7: 19.76 – 19.77 Mb
PubMed search	[1]	[2]

Basal cell adhesion molecule is a protein that in humans is encoded by the BCAM gene. BCAM has also recently been designated CD239 (cluster of differentiation 239).

Function

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

BCAM has been shown to interact with Laminin, alpha 5.

References

Further reading

• Eyler CE, Telen MJ (2006). "The Lutheran glycoprotein: a multifunctional adhesion receptor.". Transfusion 46 (4): 668–77. doi:10.1111/j.1537-2995.2006.00779.x. PMID 16584446. 
• Lewis M, Kaita H, Coghlan G; et al. (1989). "The chromosome 19 linkage group LDLR, C3, LW, APOC2, LU, SE in man.". Ann. Hum. Genet. 52 (Pt 2): 137–44. doi:10.1111/j.1469-1809.1988.tb01089.x. PMID 2907851.  CS1 maint: Multiple names: authors list (link)
• Parsons SF, Mallinson G, Holmes CH; et al. (1995). "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver.". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5496–500. doi:10.1073/pnas.92.12.5496. PMC 41722. PMID 7777537.  CS1 maint: Multiple names: authors list (link)
• Campbell IG, Foulkes WD, Senger G; et al. (1994). "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily.". Cancer Res. 54 (22): 5761–5. PMID 7954395.  CS1 maint: Multiple names: authors list (link)
• Rahuel C, Le Van Kim C, Mattei MG; et al. (1996). "A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein.". Blood 88 (5): 1865–72. PMID 8781446.  CS1 maint: Multiple names: authors list (link)
• Parsons SF, Mallinson G, Daniels GL; et al. (1997). "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms.". Blood 89 (11): 4219–25. PMID 9166867.  CS1 maint: Multiple names: authors list (link)
• El Nemer W, Rahuel C, Colin Y; et al. (1997). "Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism.". Blood 89 (12): 4608–16. PMID 9192786.  CS1 maint: Multiple names: authors list (link)
• Parsons SF, Lee G, Spring FA; et al. (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity.". Blood 97 (1): 312–20. doi:10.1182/blood.V97.1.312. PMID 11133776.  CS1 maint: Multiple names: authors list (link)
• El Nemer W, Gane P, Colin Y; et al. (2001). "Characterization of the laminin binding domains of the Lutheran blood group glycoprotein.". J. Biol. Chem. 276 (26): 23757–62. doi:10.1074/jbc.M102978200. PMID 11319237.  CS1 maint: Multiple names: authors list (link)
• Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2003). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo.". J. Biol. Chem. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066.  CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  CS1 maint: Multiple names: authors list (link)
• Shin BK, Wang H, Yim AM; et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.  CS1 maint: Multiple names: authors list (link)
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.  CS1 maint: Multiple names: authors list (link)
• Crew VK, Green C, Daniels G (2004). "Molecular bases of the antigens of the Lutheran blood group system.". Transfusion 43 (12): 1729–37. doi:10.1111/j.0041-1132.2003.00600.x. PMID 14641871.  CS1 maint: Multiple names: authors list (link)
• Zen Q, Batchvarova M, Twyman CA; et al. (2004). "B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease.". Am. J. Hematol. 75 (2): 63–72. doi:10.1002/ajh.10442. PMID 14755370.  CS1 maint: Multiple names: authors list (link)
• Kroviarski Y, El Nemer W, Gane P; et al. (2004). "Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin.". Br. J. Haematol. 126 (2): 255–64. doi:10.1111/j.1365-2141.2004.05010.x. PMID 15238148.  CS1 maint: Multiple names: authors list (link)
• Drewniok C, Wienrich BG, Schön M; et al. (2005). "Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer.". Arch. Dermatol. Res. 296 (2): 59–66. doi:10.1007/s00403-004-0481-4. PMID 15278364.  CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  CS1 maint: Multiple names: authors list (link)
• Cheng J, Kapranov P, Drenkow J; et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.  CS1 maint: Multiple names: authors list (link)
• Vainionpää N, Kikkawa Y, Lounatmaa K; et al. (2006). "Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells.". Am. J. Physiol., Cell Physiol. 290 (3): C764–75. doi:10.1152/ajpcell.00285.2005. PMID 16236823.  CS1 maint: Multiple names: authors list (link)

External links

• BCAM protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

• [Molecular basis of red blood cell adhesion to endothelium].

• Wautier JL, Wautier MP.SourceUniversité Paris Diderot Paris-7, 75013 Paris, France. jlwautier@ints.fr
• Annales pharmaceutiques françaises.Ann Pharm Fr.2011 Jan;69(1):3-6. doi: 10.1016/j.pharma.2010.10.003. Epub 2010 Dec 3.
• The extent of red blood cell adhesion is correlated with the incidence of vascular complications and the severity of the disease. Patients with sickle cell anemia (HbSS) experience vasoocclusive episodes. The adhesion of RBCs from HbSS patients is increased and related to VLA-4 exposure, which binds
• PMID 21296212

• The cell surface proteome of human mesenchymal stromal cells.

• Niehage C, Steenblock C, Pursche T, Bornhäuser M, Corbeil D, Hoflack B.SourceBiotechnology Center, Dresden University of Technology, Dresden, Germany.
• PloS one.PLoS One.2011;6(5):e20399. doi: 10.1371/journal.pone.0020399. Epub 2011 May 26.
• BACKGROUND: Multipotent human mesenchymal stromal cells (hMSCs) are considered as promising biological tools for regenerative medicine. Their antibody-based isolation relies on the identification of reliable cell surface markers.METHODOLOGY/PRINCIPAL FINDINGS: To obtain a comprehensive view of the c
• PMID 21637820

• Expression of adhesion factor CD239 in bone marrow cells in chronic myeloproliferative diseases.

• Hussein K, Theophile K, Denzer K, Kreipe H, Bock O.SourceInstitute of Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, Germany. Hussein.Kais@MH-Hannover.de
• Journal of thrombosis and thrombolysis.J Thromb Thrombolysis.2009 Oct;28(3):299-303. doi: 10.1007/s11239-008-0285-z. Epub 2008 Oct 30.
• Patients suffering from Philadelphia chromosome-negative chronic myeloproliferative disease (Ph(-) CMPD), such as polycythaemia vera (PV), are frequently JAK2(V617F)-mutated and have an elevated risk for thromboembolic complications. Recent data indicated that the molecular basis of JAK2(V617F) and
• PMID 18972067

Related Links

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• CD239 - Proposals to remove fourteen legislative measures

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Related Pictures

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★リンクテーブル★

関連記事	「CD23」「CD2」

「CD23」

　　[★]

同

FcεRII, 低親和性IgE受容体、Leucine-20、Blast-2

発現細胞

• 成熟B細胞、活性化マクロファージ、好酸球、濾胞樹状細胞、血小板

WCH.37

• B lymphocytes, where it appears to be associated with IgD
• follicular DCs, especially those in the light zone of the germinal centers
• transiently on some T cells in allergic individuals
• Langerhans cels
• monocytes
• platelets
• NK cells
• nasopharyngeal carcinoma cells
• B-CLL
• EBV-transformed B cells

機能

• IgEの受容体(低親和性)
• CD21やα-chain of the β2 integrinsにも結合する。
• 可溶性のCD23(sCD23)はIgEの産生を亢進したりIgE/Agの提示を促進したりする。またsCD23はいろいろなサイトカイン様の作用を呈する(WCH.37)

別名

• FcεRII

ファミリー

• C-type lectin

臨床関連

• 慢性リンパ性白血病(CLL)

• CD5とCD23を共発現していることが特徴

CLL and WM

• 　　慢性リンパ性白血病(CLL)と原発性マクログロブリン血症との鑑別
• CD5：　　　　陽性　　　　　　　　　　　　陰性
• CD23：　　　　陽性　　　　　　　　　　　　陰性

「CD2」

　　[★]

同

Leucine-5, SRBC receptor, LFA-2

関

CD

発現細胞

• T細胞、胸腺細胞、NK細胞

分子量

• 45-58

機能

• 接着分子、CD58(LFA-3)に結合。細胞内部でLckに結合し、T細胞を活性化

• リンパ球が抗原提示細胞と相互作用するのに重要 (IMM.343)

別名

• LFA-2, T11

ファミリー

• immunoglobulin