- 同
- langerin&HIV transmission
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/25 15:25:17」(JST)
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CD207 molecule, langerin |
Rendering based on PDB 3C22.
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Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
3C22, 3KQG, 3P5D, 3P5E, 3P5F, 3P5G, 3P5H, 3P5I, 3P7F, 3P7G, 3P7H, 4AK8, 4N32, 4N33, 4N34, 4N35, 4N36, 4N37, 4N38
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Identifiers |
Symbols |
CD207 ; CLEC4K |
External IDs |
OMIM: 604862 MGI: 2180021 HomoloGene: 9252 GeneCards: CD207 Gene |
Gene ontology |
Molecular function |
• mannose binding
• carbohydrate binding
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Cellular component |
• plasma membrane
• integral component of membrane
• endocytic vesicle
• clathrin-coated endocytic vesicle membrane
• early endosome membrane
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Biological process |
• antigen processing and presentation of peptide antigen via MHC class I
• antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
• antigen processing and presentation of exogenous peptide antigen via MHC class I
• defense response to virus
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
50489 |
246278 |
Ensembl |
ENSG00000116031 |
ENSMUSG00000034783 |
UniProt |
Q9UJ71 |
Q8VBX4 |
RefSeq (mRNA) |
NM_015717 |
NM_144943 |
RefSeq (protein) |
NP_056532 |
NP_659192 |
Location (UCSC) |
Chr 2:
70.83 – 70.84 Mb |
Chr 6:
83.67 – 83.68 Mb |
PubMed search |
[1] |
[2] |
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CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.[1][2] Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.[2][3]
Contents
- 1 Function
- 2 Clinical significance
- 3 See also
- 4 References
- 5 Further reading
- 6 External links
Function
The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[1]
Clinical significance
Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.[4][5]
See also
- Paul Langerhans
- Langerhans cell
References
- ^ a b EntrezGene 50489
- ^ a b Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances Vé, Vincent C, Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
- ^ Valladeau J, Clair-Moninot Vé, Dezutter-Dambuyant C, Pin J-J, Kissenpfennig A, Mattéi M-G, Ait-Yahia S, Bates EEM, Malissen B (2002). "Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues". Journal of Immunology 168 (2): 782–92. doi:10.4049/jimmunol.168.2.782. PMID 11777972.
- ^ De Witte L, Nabatov A, Pion M, Fluitsma D, De Jong MAWP, De Gruijl T, Piguet V, Van Kooyk Y, Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
- ^ Turville S, Wilkinson J, Cameron P, Dable J, Cunningham AL (2003). "The role of dendritic cell C-type lectin receptors in HIV pathogenesis". Journal of Leukocyte Biology 74 (5): 710–8. doi:10.1189/jlb.0503208. PMID 12960229.
Further reading
- Valladeau J, Dezutter-Dambuyant C, Saeland S (2003). "Langerin/CD207 Sheds Light on Formation of Birbeck Granules and Their Possible Function in Langerhans Cells". Immunologic Research 28 (2): 93–107. doi:10.1385/IR:28:2:93. PMID 14610287.
- Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". The FASEB Journal 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
- The Sanger Centre, The Washington University Genome Sequencing Center (1998). "Toward a Complete Human Genome Sequence". Genome Research 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances Vé, Vincent C, Schmitt D (2000). "Langerin, a Novel C-Type Lectin Specific to Langerhans Cells, is an Endocytic Receptor that Induces the Formation of Birbeck Granules". Immunity 12 (1): 71–81. doi:10.1016/S1074-7613(00)80160-0. PMID 10661407.
- Turville SG, Cameron PU, Handley A, Lin G, Pöhlmann S, Doms RW, Cunningham AL (2002). "Diversity of receptors binding HIV on dendritic cell subsets". Nature Immunology 3 (10): 975–83. doi:10.1038/ni841. PMID 12352970.
- Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A (2004). "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells". Journal of Clinical Investigation 113 (5): 701–8. doi:10.1172/JCI200419655. PMC 351318. PMID 14991068.
- Vashishta A, Fusek M, Větvička V (2005). "Possible role of procathepsin D in human cancer". Folia Microbiologica 50 (1): 71–6. doi:10.1007/BF02931296. PMID 15954536.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research 14 (10b): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Verdijk P, Dijkman R, Plasmeijer EI, Mulder AA, Zoutman WH, Mieke Mommaas A, Tensen CP (2005). "A Lack of Birbeck Granules in Langerhans Cells is Associated with a Naturally Occurring Point Mutation in the Human Langerin Gene". Journal of Investigative Dermatology 124 (4): 714–7. doi:10.1111/j.0022-202X.2005.23645.x. PMID 15816828.
- Bousarghin L (2005). "Human papillomavirus 16 virus-like particles use heparan sulfates to bind dendritic cells and colocalize with langerin in Langerhans cells". Journal of General Virology 86 (5): 1297. doi:10.1099/vir.0.80559-0.
- He B, Qiao X, Klasse PJ, Chiu A, Chadburn A, Knowles DM, Moore JP, Cerutti A (2006). "HIV-1 Envelope Triggers Polyclonal Ig Class Switch Recombination through a CD40-Independent Mechanism Involving BAFF and C-Type Lectin Receptors". Journal of Immunology 176 (7): 3931–41. doi:10.4049/jimmunol.176.7.3931. PMID 16547227.
- Ward EM, Stambach NS, Drickamer K, Taylor ME (2006). "Polymorphisms in Human Langerin Affect Stability and Sugar Binding Activity". Journal of Biological Chemistry 281 (22): 15450–6. doi:10.1074/jbc.M511502200. PMID 16567809.
- de Witte L, Nabatov A, Pion M, Fluitsma D, De Jong MAWP, De Gruijl T, Piguet V, Van Kooyk Y, Geijtenbeek TBH (2007). "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells". Nature Medicine 13 (3): 367–71. doi:10.1038/nm1541. PMID 17334373.
- Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ (2007). "Autocrine/paracrine TGF 1 is required for the development of epidermal Langerhans cells". Journal of Experimental Medicine 204 (11): 2545–52. doi:10.1084/jem.20071401. PMC 2118472. PMID 17938236.
External links
- CD207 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
Protein: lectins
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Animal |
C-type lectins
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- Asialoglycoprotein receptor
- KLRD1
- Collectin
- Mannose receptor
- proteochondroitin sulfate
- Aggrecan
- Versican
- Brevican
- Neurocan
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Other
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- Calnexin
- Calreticulin
- CD22
- CD33
- Galectin
- Myelin-associated glycoprotein
- N-Acetylglucosamine receptor
- Selectin
- Sialoadhesin
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Plant |
- Toxalbumins
- Mitogens
- Concanavalin A
- Phytohaemagglutinin
- Pokeweed mitogen
- Legume lectin
- BanLec
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UpToDate Contents
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English Journal
- Generation and functional analysis of human TNF-α/iNOS-producing dendritic cells (Tip-DC).
- Wilsmann-Theis D, Koch S, Mindnich C, Bonness S, Schnautz S, von Bubnoff D, Bieber T.SourceDepartment of Dermatology and Allergy, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany.
- Allergy.Allergy.2013 Jun 6. doi: 10.1111/all.12172. [Epub ahead of print]
- BACKGROUND: A unique type of CD11cpos dendritic cells (DC) is abundant in inflamed tissue, for example, in chronic inflammatory skin diseases. Due to their remarkable production of tumor necrosis factor (TNF)-α and inducible NO synthase (iNOS), these cells have been referred to as TNF and iNOS-prod
- PMID 23742057
- Appearance of remodelled and dendritic cell-rich alveolar-lymphoid interfaces provides a structural basis for increased alveolar antigen uptake in chronic obstructive pulmonary disease.
- Mori M, Andersson CK, Svedberg KA, Glader P, Bergqvist A, Shikhagaie M, Löfdahl CG, Erjefält JS.SourceDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
- Thorax.Thorax.2013 Jun;68(6):521-31. doi: 10.1136/thoraxjnl-2012-202879. Epub 2013 Feb 14.
- RATIONALE: The alveolar pathology in chronic obstructive pulmonary disease (COPD) involves antigen-driven immune events. However, the induction sites of alveolar adaptive immune responses have remained poorly investigated.OBJECTIVES: To explore the hypothesis that interfaces between the alveolar lum
- PMID 23412435
- Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia.
- Dauch JR, Bender DE, Luna-Wong LA, Hsieh W, Yanik BM, Kelly ZA, Cheng HT.SourceDepartment of Neurology, University of Michigan Medical Center, Ann Arbor, MI, USA. chengt@umich.edu.
- Journal of neuroinflammation.J Neuroinflammation.2013 May 14;10:64. doi: 10.1186/1742-2094-10-64.
- BACKGROUND: Langerhans cells (LCs) are antigen-presenting dendritic cells located in the skin. It has been reported that LC activation is associated with painful diabetic neuropathy (PDN); however, the mechanism of LC activation is still unclear.METHODS: The db/db mouse, a rodent model of PDN, was u
- PMID 23672639
Japanese Journal
- A Case of Langerhans Cell Histiocytosis Presenting with Bilateral Otorrhea
- , , , , , ,
- 耳鼻咽喉科臨床 補冊 137(0), 30-31, 2013
- … Immunohistology revealed positive staining of the lesional cells with CD1a and Langerin (CD207). …
- NAID 130004558702
- 難治性耳漏を初発症状としたランゲルハンス細胞組織球症例
- 千葉 真人,伊藤 吏,渡辺 知緒 [他],窪田 俊憲,太田 伸男,欠畑 誠治,青柳 優
- 耳鼻咽喉科臨床 106(5), 417-422, 2013
- … Immunohistology revealed positive staining of the lesional cells with CD1a and Langerin (CD207). …
- NAID 130003374062
- Spontaneously Regressed Langerhans Cell Histiocytosis of Lymph Nodes in an Elderly Patient
- , ,
- Internal Medicine 46(20), 1757-1760, 2007
- … A histologic examination demonstrated a proliferation of histiocytoid cells which were positive for CD1a, S-100 protein, and Lagerin (CD207). …
- NAID 130000075960
Related Links
- CD207(Langerin)は、真皮や粘膜に分布する未熟樹状細胞(DC)のサブセットであるランゲルハンス細胞(LC)に選択的に発現するとされています。CD207は、主にN型糖鎖が付加した分子量40kDaのタンパクで、ジスルフィド結合を ...
- CD207はLangerinとしても知られる、48kDaのII型膜貫通タンパク質で、C-type lectinに属します。また、細胞外領域に糖鎖認識ドメイン(carbohydrate recognition domain)をもちます。Langerinは表皮ランゲルハンス細胞と真皮のCD103+樹状 ...
Related Pictures
★リンクテーブル★
[★]
- 同
- Leucine-5, SRBC receptor, LFA-2
- 関
- CD
発現細胞
分子量
機能
- リンパ球が抗原提示細胞と相互作用するのに重要 (IMM.343)
別名
ファミリー
[★]
発現細胞
分子量
機能
- Ca2+のイオンチャネル(オリゴマー化して)。
- 多分、B細胞活性化の調節に関与
ファミリー
- cantains 4 transmembrane segments
- 同
- B1