同: Sialoadhesin, Sialic acid-binding immu- noglobulin-like lectin-1

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/19 02:30:31」(JST)

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Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients suffering from rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues.^[2] It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed between a highly conserved arginine residue (from the v-set domain to the 3'-sialyllactose) and the carboxylate group of the sialic acid.^[2] Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169).^[3]

Sialoadhesin predominantly binds neutrophils, but can also bind monocytes, natural killer cells, B cells and a subset of cytotoxic T cells by interacting with sialic acid molecules in the ligands on their surfaces.^[4]

Sialaodhesin (CD169) positive macrophages, along with mesenchymal stem cells and beta-adrenergic neurons, form the hematopoietic stem cell niche in the bone marrow. CD169+ macrophages mediate signaling between the various cells and seem to promote hematopoietic stem cell retention to the niche.

References

^ PDB: 2BVE; Zaccai NR, May AP, Robinson RC, Burtnick LD, Crocker PR, Brossmer R, Kelm S, Jones EY (February 2007). "Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin". J. Mol. Biol. 365 (5): 1469–79. doi:10.1016/j.jmb.2006.10.084. PMID 17137591.
^ ^a ^b Hartnell A, Steel J, Turley H, Jones M, Jackson DG, Crocker PR (January 2001). "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations". Blood 97 (1): 288–96. doi:10.1182/blood.V97.1.288. PMID 11133773.
^ Varki A (2001-09-10). "Sialoadhesin, Siglec-1 (CD169)". Protein Reviews on the Web (PROW) Guide. United States National Center for Biotechnology Information (NCBI). Retrieved 2011-04-15.
^ Kelm S, Pelz A, Schauer R, Filbin M, Tang S, de Bellard M, Schnaar R, Mahoney J, Hartnell A, Bradfield P (1994). "Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily". Curr Biol 4 (11): 965–72. doi:10.1016/S0960-9822(00)00220-7. PMID 7533044.

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English Journal

Lymph Node Macrophages Restrict Murine Cytomegalovirus Dissemination.

Farrell HE1, Davis-Poynter N1, Bruce K1, Lawler C1, Dolken L2, Mach M3, Stevenson PG4.
Journal of virology.J Virol.2015 Jul 15;89(14):7147-58. doi: 10.1128/JVI.00480-15. Epub 2015 Apr 29.
Cytomegaloviruses (CMVs) establish chronic infections that spread from a primary entry site to secondary vascular sites, such as the spleen, and then to tertiary shedding sites, such as the salivary glands. Human CMV (HCMV) is difficult to analyze, because its spread precedes clinical presentation.
PMID 25926638

Increased Expression of CD169 on Blood Monocytes and Its Regulation by Virus and CD8 T Cells in Macaque Models of HIV Infection and AIDS.

Kim WK1, McGary CM1, Holder GE1, Filipowicz AR1, Kim MM1, Beydoun HA2, Cai Y3, Liu X4, Sugimoto C3, Kuroda MJ3.
AIDS research and human retroviruses.AIDS Res Hum Retroviruses.2015 Jul;31(7):696-706. doi: 10.1089/AID.2015.0003. Epub 2015 May 11.
Increased expression of CD169 on monocytes has been reported in HIV-1-infected humans. Using rhesus macaque models of HIV infection, we sought to investigate whether simian immunodeficiency virus (SIV) infection upregulates CD169 expression on monocytes/macrophages. We also sought to determine wheth
PMID 25891017

PRRS virus receptors and their role for pathogenesis.

Zhang Q1, Yoo D2.
Veterinary microbiology.Vet Microbiol.2015 Jun 12;177(3-4):229-41. doi: 10.1016/j.vetmic.2015.04.002. Epub 2015 Apr 13.
Porcine reproductive and respiratory syndrome virus (PRRSV) is endemic in most pig producing countries worldwide and causes enormous economic losses to the swine industry. Specifically differentiated porcine alveolar macrophages are the primary target for PRRSV infection in pigs. At least six cellul
PMID 25912022

Japanese Journal

Seventeen-Year Observation on Urinary Cadmium and β2-Microglobulin in Inhabitants After Cessation of Cadmium-Exposure in Japan

Sato Reiko,Kido Teruhiko,Honda Ryumon,Nishijo Muneko,Nakagawa Hideaki,Kobayashi Etsuko,Suwazono Yasushi　
Bulletin of Environmental Contamination and Toxicology 84(4), 363-367, 2010-04
The purpose of this study was to clarify the change and relationship of urinary cadmium (Cd) and β2-microglobulin (β2-MG) concentrations of inhabitants in Cd-polluted areas after soil restoration. The …
NAID 120002029107

Related Pictures

PPT - CD169 + Macrophages, Lymph node sentinels. PowerPoint Presentation - ID:3652750 CD169 Antibody, clone 3D6.112 (Monoclonal Antibody) | AbD Serotec CD169陽性マクロファージの分化制御機構の解明 | 組織・研究内容 CD169 mediates the capture of exosomes in spleen and lymph node | Blood Journal CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell Frontiers | Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T

★リンクテーブル★

リンク元	「シアロアドヘシン」
関連記事	「CD16」「CD1」

「シアロアドヘシン」

Sialoadhesin
	Structure of the N-terimal domain of mouse sialoadhesin.
Identifiers
Symbol	SIGLEC1
Alt. symbols	SN, CD169
Entrez	6614
HUGO	11127
OMIM	600751
PDB	2BVE
RefSeq	NM_023068
UniProt	Q9BZZ2
Other data
Locus	Chr. 20 p13

　　[★]

英: sialoadhesin
同: CD169

シアル酸結合タンパク質

「CD16」

　　[★]

同: FcγRIII、低親和性Fcγ受容体 lowaffinity Fcγ receptor

FcγRIII
NK細胞の抗体依存性細胞介在性細胞傷害(ADCC)に重要

発現細胞

好中球、NK細胞、マクロファージ

機能

Component of low affinity Fc receptor, FcγRIII, mediates phagocytosis and antibody-dependent cell-mediated cytotoxicity ADCC

「CD1」

　　[★]

同: leucine-6, CD1A through E

種類

CD1a, CD1b, CD1c, CD1d

発現組織

胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

43-49

機能

MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

[pmid17137591-1] PDB: 2BVE; Zaccai NR, May AP, Robinson RC, Burtnick LD, Crocker PR, Brossmer R, Kelm S, Jones EY (February 2007). "Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin". J. Mol. Biol. 365 (5): 1469–79. doi:10.1016/j.jmb.2006.10.084. PMID 17137591.

[Hartnell_2001-2] Hartnell A, Steel J, Turley H, Jones M, Jackson DG, Crocker PR (January 2001). "Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations". Blood 97 (1): 288–96. doi:10.1182/blood.V97.1.288. PMID 11133773.

[titlePROW_Guide:_Sialoadhesin.2C_Siglec-1_.28CD169.29-3] Varki A (2001-09-10). "Sialoadhesin, Siglec-1 (CD169)". Protein Reviews on the Web (PROW) Guide. United States National Center for Biotechnology Information (NCBI). Retrieved 2011-04-15.

[4] Kelm S, Pelz A, Schauer R, Filbin M, Tang S, de Bellard M, Schnaar R, Mahoney J, Hartnell A, Bradfield P (1994). "Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily". Curr Biol 4 (11): 965–72. doi:10.1016/S0960-9822(00)00220-7. PMID 7533044.

匿名

検索

案内

案内

CD169