- 同
- Activated leukocyte cell adhesion molecule, Neurolin, BEN
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/09/21 02:57:07」(JST)
[Wiki en表示]
ALCAM |
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Available structures |
PDB |
Ortholog search: PDBe RCSB |
List of PDB id codes |
5A2F
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Identifiers |
Aliases |
ALCAM, CD166, MEMD, activated leukocyte cell adhesion molecule |
External IDs |
MGI: 1313266 HomoloGene: 1229 GeneCards: 214 |
Gene ontology |
Molecular function |
• protein binding
• receptor binding
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Cellular component |
• integral component of membrane
• cell projection
• membrane
• focal adhesion
• intrinsic component of plasma membrane
• Q14330621
• integral component of plasma membrane
• T cell receptor complex
• extracellular region
• axon
• neuronal cell body
• dendrite
• immunological synapse
• extracellular exosome
• external side of plasma membrane
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Biological process |
• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
• adaptive immune response
• immune system process
• neuron projection extension
• cell adhesion
• motor neuron axon guidance
• axon extension involved in axon guidance
• signal transduction
• retinal ganglion cell axon guidance
• axon guidance
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Sources:Amigo / QuickGO |
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Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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NM_001627
NM_001243280
NM_001243281
NM_001243283
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RefSeq (protein) |
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NP_001230209.1
NP_001230212.1
NP_001618.2
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Location (UCSC) |
Chr 3: 105.37 – 105.58 Mb |
Chr 16: 52.25 – 52.45 Mb |
PubMed search |
[1] |
[2] |
Wikidata |
View/Edit Human |
View/Edit Mouse |
CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.[3][4] It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands. CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. Recently, CD166 has also been used as a potential cancer stem cell marker.
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.
- ^ "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule".
Further reading
- Whitney GS, Starling GC, Bowen MA, et al. (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site.". J. Biol. Chem. 270 (31): 18187–90. doi:10.1074/jbc.270.31.18187. PMID 7543097.
- Bajorath J, Bowen MA, Aruffo A (1996). "Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.". Protein Sci. 4 (8): 1644–7. doi:10.1002/pro.5560040822. PMC 2143187. PMID 8520490.
- Skonier JE, Bowen MA, Emswiler J, et al. (1996). "Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM.". Biochemistry. 35 (38): 12287–91. doi:10.1021/bi961038k. PMID 8823162.
- Singer NG, Mitra R, Lialios F, et al. (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes.". Immunol. Lett. 58 (1): 9–14. doi:10.1016/S0165-2478(97)02707-7. PMID 9436462.
- Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule).". Am. J. Pathol. 152 (3): 805–13. PMC 1858405. PMID 9502422.
- Cortés F, Deschaseaux F, Uchida N, et al. (1999). "HCA, an immunoglobulin-like adhesion molecule present on the earliest human hematopoietic precursor cells, is also expressed by stromal cells in blood-forming tissues.". Blood. 93 (3): 826–37. PMID 9920831.
- Tomita K, van Bokhoven A, Jansen CF, et al. (2000). "Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin.". Biochem. Biophys. Res. Commun. 267 (3): 870–4. doi:10.1006/bbrc.1999.2040. PMID 10673383.
- van Kempen LC, Nelissen JM, Degen WG, et al. (2001). "Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction.". J. Biol. Chem. 276 (28): 25783–90. doi:10.1074/jbc.M011272200. PMID 11306570.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kristiansen G, Pilarsky C, Wissmann C, et al. (2003). "ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions.". Prostate. 54 (1): 34–43. doi:10.1002/pros.10161. PMID 12481253.
- Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
- Fujiwara H, Tatsumi K, Kosaka K, et al. (2003). "Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166).". J. Clin. Endocrinol. Metab. 88 (7): 3437–43. doi:10.1210/jc.2002-021888. PMID 12843199.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- van Kempen LC, Meier F, Egeblad M, et al. (2004). "Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis.". J. Invest. Dermatol. 122 (5): 1293–301. doi:10.1111/j.0022-202X.2004.22531.x. PMID 15140234.
- Zimmerman AW, Nelissen JM, van Emst-de Vries SE, et al. (2005). "Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases.". J. Cell. Sci. 117 (Pt 13): 2841–52. doi:10.1242/jcs.01139. PMID 15169840.
- Ikeda K, Quertermous T (2005). "Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function.". J. Biol. Chem. 279 (53): 55315–23. doi:10.1074/jbc.M407776200. PMID 15496415.
- Verma A, Shukla NK, Deo SV, et al. (2005). "MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in esophageal squamous cell carcinoma.". Oncology. 68 (4–6): 462–70. doi:10.1159/000086989. PMID 16024937.
- Lunter PC, van Kilsdonk JW, van Beek H, et al. (2005). "Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity". Cancer Res. 65 (19): 8801–8. doi:10.1158/0008-5472.CAN-05-0378. PMID 16204050.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
External links
- ALCAM at the US National Library of Medicine Medical Subject Headings (MeSH)
Protein: scleroproteins
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Extracellular matrix |
Collagen |
Fibril forming |
- type I
- type II (COL2A1)
- type III
- type V
- COL24A1
- COL26A1
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Other |
- FACIT: type IX
- type XII (COL12A1)
- COL14A1
- COL16A1
- COL19A1
- COL20A1
- COL21A1
- COL22A1
- basement membrane: type IV
- COL4A1
- COL4A2
- COL4A3
- COL4A4
- COL4A5
- COL4A6
- multiplexin: COL15A1
- type XVIII
- transmembrane: COL13A1
- COL17A1
- COL23A1
- COL25A1
- other: type VI
- COL6A1
- COL6A2
- COL6A3
- COL6A5
- type VII (COL7A1)
- type VIII
- type X (COL10A1)
- type XI
- COL27A1
- COL28A1
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Enzymes |
- Prolyl hydroxylase/Lysyl hydroxylase
- Cartilage associated protein/Leprecan
- ADAMTS2
- Procollagen peptidase
- Lysyl oxidase
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Laminin |
- alpha
- LAMA1
- LAMA2
- LAMA3
- LAMA4
- LAMA5
- beta
- gamma
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Other |
- ALCAM
- Elastin
- Vitronectin
- FRAS1
- FREM2
- Decorin
- FAM20C
- ECM1
- Matrix gla protein
- Tectorin
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Other |
- Keratin/Cytokeratin
- Gelatin
- Reticulin
- Cartilage oligomeric matrix protein
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English Journal
- Influence of inflammation on the immunological profile of adult-derived human liver mesenchymal stromal cells and stellate cells.
- Raicevic G1, Najar M2, Najimi M3, El Taghdouini A4, van Grunsven LA4, Sokal E3, Toungouz M5.
- Cytotherapy.Cytotherapy.2015 Feb;17(2):174-85. doi: 10.1016/j.jcyt.2014.10.001. Epub 2014 Nov 21.
- BACKGROUND AIMS: Stem cell therapy for liver diseases has recently emerged as a promising alternative to liver transplantation. Eligible cells should have an appropriate immunophenotype. The aim of the present study was to define the immunological profile of two human liver-derived mesenchymal strom
- PMID 25455740
- Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma.
- Zhao M1, Zhang Y2, Zhang H3, Wang S3, Zhang M4, Chen X5, Wang H6, Zeng G7, Chen X8, Liu G9, Zhou C1.
- Lung cancer (Amsterdam, Netherlands).Lung Cancer.2015 Feb;87(2):98-106. doi: 10.1016/j.lungcan.2014.11.017. Epub 2014 Dec 3.
- BACKGROUND: Since cancer stem cells exhibit embryonic-like self-renewal characteristics and malignant behavior, including drug resistance and metastasis, they may be the origin of tumorigenesis and cancer recurrence. Cancer cell stemness is also highly relevant to cancer in hypoxic environments.METH
- PMID 25512094
- IL-6/STAT3 signaling pathway contributes to chondrogenic differentiation of human mesenchymal stem cells.
- Kondo M1, Yamaoka K, Sakata K, Sonomoto K, Lin L, Nakano K, Tanaka Y.
- Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2015 Jan 20. doi: 10.1002/art.39036. [Epub ahead of print]
- Objective: Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into chondrocytes. Articular cartilage contains MSC-like chondroprogenitor cells, suggesting their involvement in the maintenance of cartilage homeostasis by a self-repair mechanism. Interleukin (IL)-6 is a cytokin
- PMID 25604648
Japanese Journal
- Selective development of myogenic mesenchymal cells from human embryonic and induced pluripotent stem cells.
- Awaya Tomonari,Kato Takeo,Mizuno Yuta,Chang Hsi,Niwa Akira,Umeda Katsutsugu,Nakahata Tatsutoshi,Heike Toshio
- PloS one 7(12), 2012-12-07
- … These mesenchymal cells, which were obtained by dissociation and re-cultivation of embryoid bodies, uniformly expressed CD56 and the mesenchymal markers CD73, CD105, CD166, and CD29, and finally differentiated into mature myotubes in vitro. …
- NAID 120005122354
- 名倉 一成,国分 毅,美舩 泰,坂田 亮介,西本 華子,無藤 智之
- 肩関節 36(2), 531-535, 2012
- … CD29, CD44, CD105 and CD166. …
- NAID 130002103729
Related Links
- CD166抗原は、Activaed leukocyte cell adhesion molecule(ALCAM)として知られているⅠ型膜貫通タンパクです。10箇所のN結合型糖鎖附加部位を含む、免疫グロブリンスーパーファミリー分子です。分子量100-105kDaで、5個の細胞外Ig様 ...
- クローンREA370は、Ⅰ型1回膜貫通タンパク質でactivated leukocyte cell adhesion molecule (ALCAM)としても知られる、マウスCD166抗原を認識します。CD166はIgスーパージーンファミリーに属し、活性化白血球や胸腺上皮細胞で発現して ...
Related Pictures
★リンクテーブル★
[★]
- 同
- FcγRIII、低親和性Fcγ受容体 lowaffinity Fcγ receptor
- FcγRIII
- NK細胞の抗体依存性細胞介在性細胞傷害(ADCC)に重要
発現細胞
機能
- Component of low affinity Fc receptor, FcγRIII, mediates phagocytosis and antibody-dependent cell-mediated cytotoxicity ADCC
[★]
- 同
- leucine-6, CD1A through E
種類
発現組織
- 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)
分子量
機能
- MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens