CD102

関

intracellular adhesion molecule 2, ICAM-2:CD102

関

intracellular adhesion molecule 2, ICAM-2:CD102

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/25 17:31:04」(JST)

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Intercellular adhesion molecule 2
PDB rendering based on 1zxq.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZXQ
Identifiers
Symbols	ICAM2 ; CD102
External IDs	OMIM: 146630 MGI: 96394 HomoloGene: 675 GeneCards: ICAM2 Gene
Gene ontology Molecular function • integrin binding Cellular component • uropod • plasma membrane • integral to plasma membrane Biological process • cell-cell adhesion • regulation of immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3384	15896
Ensembl	ENSG00000108622	ENSMUSG00000001029
UniProt	P13598	P35330
RefSeq (mRNA)	NM_000873	NM_010494
RefSeq (protein)	NP_000864	NP_034624
Location (UCSC)	Chr 17: 62.08 – 62.1 Mb	Chr 11: 106.38 – 106.39 Mb
PubMed search	[1]	[2]

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

Protein structure

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions

ICAM-2 molecules regulate spermatid adhesion on Sertori cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Interactions

ICAM2 has been shown to interact with EZR.

See also

• Cluster of differentiation

References

Further reading

• Simmons DL (1995). "The role of ICAM expression in immunity and disease.". Cancer Surv. 24: 141–55. PMID 7553659. 
• Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions.". Immunol. Res. 17 (3): 313–27. doi:10.1007/BF02786454. PMID 9638475. 
• Lalor PF, Shields P, Grant A, Adams DH (2002). "Recruitment of lymphocytes to the human liver.". Immunol. Cell Biol. 80 (1): 52–64. doi:10.1046/j.1440-1711.2002.01062.x. PMID 11869363. 
• Yonekawa K, Harlan JM (2005). "Targeting leukocyte integrins in human diseases.". J. Leukoc. Biol. 77 (2): 129–40. doi:10.1189/jlb.0804460. PMID 15548573. 
• de Fougerolles AR, Stacker SA, Schwarting R, Springer TA (1991). "Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.". J. Exp. Med. 174 (1): 253–67. doi:10.1084/jem.174.1.253. PMC 2118873. PMID 1676048. 
• Sansom D, Borrow J, Solomon E, Trowsdale J (1992). "The human ICAM2 gene maps to 17q23-25.". Genomics 11 (2): 462–4. doi:10.1016/0888-7543(91)90157-A. PMID 1769660. 
• Staunton DE, Dustin ML, Springer TA (1989). "Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.". Nature 339 (6219): 61–4. doi:10.1038/339061a0. PMID 2497351. 
• Bujía J, Holly A, Kim C, et al. (1994). "Expression of human intercellular adhesion molecules in middle ear cholesteatoma.". Am J Otolaryngol 15 (4): 271–5. doi:10.1016/0196-0709(94)90094-9. PMID 7526720. 
• de Fougerolles AR, Qin X, Springer TA (1994). "Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.". J. Exp. Med. 179 (2): 619–29. doi:10.1084/jem.179.2.619. PMC 2191386. PMID 7905020. 
• Butini L, De Fougerolles AR, Vaccarezza M, et al. (1994). "Intercellular adhesion molecules (ICAM)-1 ICAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formation.". Eur. J. Immunol. 24 (9): 2191–5. doi:10.1002/eji.1830240939. PMID 7916296. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Hirao M, Sato N, Kondo T, et al. (1996). "Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.". J. Cell Biol. 135 (1): 37–51. doi:10.1083/jcb.135.1.37. PMC 2121020. PMID 8858161. 
• Bernstein CN, Sargent M, Gallatin WM, Wilkins J (1996). "Beta 2-integrin/intercellular adhesion molecule (ICAM) expression in the normal human intestine.". Clin. Exp. Immunol. 106 (1): 160–9. PMID 8870715. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Casasnovas JM, Springer TA, Liu JH, et al. (1997). "Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.". Nature 387 (6630): 312–5. doi:10.1038/387312a0. PMID 9153399. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Sainio M, Zhao F, Heiska L, et al. (1997). "Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton.". J. Cell. Sci. 110. ( Pt 18): 2249–60. PMID 9378774. 
• Yonemura S, Hirao M, Doi Y, et al. (1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2.". J. Cell Biol. 140 (4): 885–95. doi:10.1083/jcb.140.4.885. PMC 2141743. PMID 9472040. 
• Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease.". Clin. Immunol. Immunopathol. 86 (2): 147–60. doi:10.1006/clin.1997.4462. PMID 9473377. 

External links

• ICAM2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

• Development and characterization of a monoclonal antibody specific for bovine CD209.

• Park KT1, Burnett S1, Davis WC2.
• Veterinary immunology and immunopathology.Vet Immunol Immunopathol.2015 Feb 15;163(3-4):216-20. doi: 10.1016/j.vetimm.2014.12.008. Epub 2014 Dec 23.
• Dendritic cells (DC) play a central role in tailoring the immune response to pathogens. Effector activity is mediated through pattern recognition receptors (PRRs) that recognize pathogen associated molecular patterns (PAMPS). C-type lectin receptors (CLR) comprise a group of PRRs that recognize a br
• PMID 25593043

• Cell surface phenotype profiles distinguish stable and progressive chronic lymphocytic leukemia.

• Huang PY1, Best OG, Almazi JG, Belov L, Davis ZA, Majid A, Dyer MJ, Pascovici D, Mulligan SP, Christopherson RI.
• Leukemia & lymphoma.Leuk Lymphoma.2014 Sep;55(9):2085-92. doi: 10.3109/10428194.2013.867486. Epub 2014 Jan 24.
• Chronic lymphocytic leukemia (CLL) is clinically heterogeneous. While some patients have indolent disease for many years, 20-30% will progress and ultimately die of their disease. CLL may be classified by the Rai or Binet staging system, mutational status of the immunoglobulin variable heavy-chain g
• PMID 24289109

• Adhesion molecule expression and function of primary endothelial cells in benign and malignant tissues correlates with proliferation.

• Sievert W1, Tapio S2, Breuninger S1, Gaipl U3, Andratschke N1, Trott KR4, Multhoff G1.
• PloS one.PLoS One.2014 Mar 14;9(3):e91808. doi: 10.1371/journal.pone.0091808. eCollection 2014.
• BACKGROUND: Comparative analysis of the cellular biology of the microvasculature in different tissues requires the availability of viable primary endothelial cells (ECs). This study describes a novel method to isolate primary ECs from healthy organs, repair blastemas and tumors as examples of non-pr
• PMID 24632811

Japanese Journal

• Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues

• Kajimoto Kazuaki,Hossen Md. Nazir,Hida Kyoko,Ohga Noritaka,Akita Hidetaka,Hyodo Mamoru,Hida Yasuhiro,Harashima Hideyoshi
• Journal of Immunological Methods 357(1-2), 43-50, 2010-05-31
• … The protocol involves the preparation of a single cell suspension (digestion, filtration and density gradient centrifugation), immunomagnetic enrichment of the CD45- cell population and the purification of the MECs by a combination of common specific markers CD31, CD102 and isolectin B4. …
• NAID 120002248665

Related Links

• Heidelberg - Speedmaster CD 102

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★リンクテーブル★

リンク元	「接着分子」
関連記事	「CD1」「CD10」

「接着分子」

　　[★]

英

adhesion molecule

同

接着因子

関

接着分子のファミリー

• インテグリンファミリー
• Igスーパーファミリー
• セレクチンファミリー
• CD44ファミリー
• カドヘリンファミリー

白血球の相互作用に関与している接着分子 (IMM.87)

グループ名	機能	名称	別名		組織分布	リガンド
セレクチン	炭化水素鎖に結合。 白血球-内皮細胞の反応を開始	P-selectin	PADGEN	CD62P	活性化した内皮細胞、活性化した血小板	PSGL-1, sialyl-Lewisx
		E-selectin	ELAM-1	CD62E	活性化した内皮細胞	sialyl-Lewisx
インテグリン	CAMや細胞外マトリックスに結合。 強い結合	LFA-1	αL:β2	CD11a:CD18	単球、T細胞、マクロファージ、好中球、樹状細胞	ICAMs
		CR3, Mac-1	αM:β2	CD11b:CD18	好中球、単球、マクロファージ	ICAM-1, iC3b, fibrinogen
		CR4, p150.95	αX:β2	CD11c:CD18	樹状細胞、マクロファージ、好中球	iC3b
		VLA-5	α5:β1	CD49d:CD29	単球、マクロファージ	fibronectin
免疫グロブリンスーパーファミリー	細胞結合で様々に働く。 インテグリンの基質	ICAM-1		CD54	活性化した内皮細胞	LFA-1, MAC1
		ICAM-2		CD102	非活性化状態の内皮細胞、樹状細胞	LFA-1
		VCAM-1		CD106	活性化した内皮細胞	VLA-4
		PECAM		CD31	活性化した白血球、内皮細胞間の結合	CD31

白血球の相互作用に関与している免疫グロブリンスーパーファミリーの接着分子 (IMM.329)

名称		分布組織	リガンド
CD2	LFA-2	T細胞	LFA-1	CD53
ICAM-1	CD54	活性化した血管、リンパ球、樹状細胞	LFA-1, Mac-1
ICAM-2	CD102	非活性化状態の血管	LFA-1
ICAM-3	CD50	Naive T cells	DC-SIGN, LFA-1
LFA-3	CD58	リンパ球、APC	CD2
VCAM-1	CD106	活性化した内皮細胞	VLA-4

-接着分子

-細胞接着分子

-カドヘリン

「CD1」

　　[★]

同

leucine-6, CD1A through E

種類

• CD1a, CD1b, CD1c, CD1d

発現組織

• 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

• 43-49

機能

• MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

「CD10」

　　[★]

同

common acute lymphoid leukemia antigen, nephrilysin

発現細胞

• B細胞やT細胞前駆体。骨髄間質細胞(bone marrow stromal cell)

分子量

• 100kDa

機能

• Zinc metalloproteinase, marker for pre-B acute lymphatic leukemia (ALL)

別名

• Neutral endopeptidase, common acute lymphocytic leukemia antigen(CALLA)