- 同
- eotaxin
- 同
- eotaxin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/09 14:36:47」(JST)
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Chemokine (C-C motif) ligand 11 |
PDB rendering based on 1eot. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1EOT, 2EOT
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Identifiers |
Symbols |
CCL11; SCYA11 |
External IDs |
OMIM: 601156 MGI: 103576 HomoloGene: 7929 GeneCards: CCL11 Gene |
Gene Ontology |
Molecular function |
• chemokine activity
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Cellular component |
• extracellular region
• extracellular space
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Biological process |
• positive regulation of endothelial cell proliferation
• protein phosphorylation
• cellular calcium ion homeostasis
• chemotaxis
• inflammatory response
• immune response
• cytoskeleton organization
• cell adhesion
• signal transduction
• regulation of cell shape
• response to radiation
• response to virus
• positive regulation of cell migration
• positive regulation of actin filament polymerization
• positive regulation of Rac GTPase activity
• eosinophil chemotaxis
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
6356 |
20292 |
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Ensembl |
ENSG00000172156 |
ENSMUSG00000020676 |
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UniProt |
P51671 |
P48298 |
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RefSeq (mRNA) |
NM_002986.2 |
NM_011330.3 |
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RefSeq (protein) |
NP_002977.1 |
NP_035460.1 |
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Location (UCSC) |
Chr 17:
32.61 – 32.62 Mb |
Chr 11:
82.06 – 82.06 Mb |
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PubMed search |
[1] |
[2] |
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C-C motif chemokine 11 also known as eotaxin-1 is a protein that in humans is encoded by the CCL11 gene. This gene is encoded on three exons and is located on chromosome 17.[1][2]
Function
CCL11 is a small cytokine belonging to the CC chemokine family. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses.[3][4][5] The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2,[6] CCR3[1] and CCR5.[6] However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.[7]
Increased CCL11 levels in blood plasma are associated with aging in mice and humans.[8] Additionally, it has been demonstrated that exposing young mice to CCL11 or the blood plasma of older mice decreases their neurogenesis and cognitive performance on behavioural tasks thought to be dependent on neurogenesis in the hippocampus.[8]
References
- ^ a b Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". J. Biol. Chem. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
- ^ Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochem. Biophys. Res. Commun. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
- ^ Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ (1994). "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.". J. Exp Med. 179 (3): 881–7. doi:10.1084/jem.179.3.881. PMC 2191401. PMID 7509365. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2191401/.
- ^ Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". J. Clin. Invest. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214. //www.ncbi.nlm.nih.gov/pmc/articles/PMC507095/.
- ^ Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nat. Med. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956.
- ^ a b Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (2001). "Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5". Blood 97 (7): 1920–4. doi:10.1182/blood.V97.7.1920. PMID 11264152.
- ^ Baggiolini M, Dewald B, Moser B (1997). "Human chemokines: an update". Annu. Rev. Immunol. 15: 675–705. doi:10.1146/annurev.immunol.15.1.675. PMID 9143704.
- ^ a b Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T (September 2011). "The ageing systemic milieu negatively regulates neurogenesis and cognitive function". Nature 477 (7362): 90–4. doi:10.1038/nature10357. PMC 3170097. PMID 21886162. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3170097/.
Further reading
- Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, et al. (1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.". Nat. Med. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956.
- Ponath PD, Qin S, Ringler DJ, et al. (1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.". J. Clin. Invest. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214. //www.ncbi.nlm.nih.gov/pmc/articles/PMC507095/.
- Kitaura M, Nakajima T, Imai T, et al. (1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.". J. Biol. Chem. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
- Daugherty BL, Siciliano SJ, DeMartino JA, et al. (1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor.". J. Exp. Med. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2192548/.
- Choe H, Farzan M, Sun Y, et al. (1996). "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.". Cell 85 (7): 1135–48. doi:10.1016/S0092-8674(00)81313-6. PMID 8674119.
- Ponath PD, Qin S, Post TW, et al. (1996). "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.". J. Exp. Med. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2192612/.
- Bartels J, Schlüter C, Richter E, et al. (1996). "Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants.". Biochem. Biophys. Res. Commun. 225 (3): 1045–51. doi:10.1006/bbrc.1996.1292. PMID 8780731.
- Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, et al. (1997). "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.". Genomics 41 (3): 471–6. doi:10.1006/geno.1997.4656. PMID 9169149.
- Hein H, Schlüter C, Kulke R, et al. (1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.". Biochem. Biophys. Res. Commun. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
- Nibbs RJ, Wylie SM, Yang J, et al. (1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.". J. Biol. Chem. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
- Rubbert A, Combadiere C, Ostrowski M, et al. (1998). "Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.". J. Immunol. 160 (8): 3933–41. PMID 9558100.
- Noso N, Bartels J, Mallet AI, et al. (1998). "Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.". Eur. J. Biochem. 253 (1): 114–22. doi:10.1046/j.1432-1327.1998.2530114.x. PMID 9578468.
- Crump MP, Rajarathnam K, Kim KS, et al. (1998). "Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.". J. Biol. Chem. 273 (35): 22471–9. doi:10.1074/jbc.273.35.22471. PMID 9712872.
- Sabroe I, Hartnell A, Jopling LA, et al. (1999). "Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.". J. Immunol. 162 (5): 2946–55. PMID 10072545.
- Jinquan T, Quan S, Feili G, et al. (1999). "Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4.". J. Immunol. 162 (7): 4285–92. PMID 10201960.
- Klein RS, Williams KC, Alvarez-Hernandez X, et al. (1999). "Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS.". J. Immunol. 163 (3): 1636–46. PMID 10415069.
- Blanpain C, Migeotte I, Lee B, et al. (1999). "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.". Blood 94 (6): 1899–905. PMID 10477718.
- Zhang J, Lathbury LJ, Salamonsen LA (2000). "Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium.". Biol. Reprod. 62 (2): 404–11. doi:10.1095/biolreprod62.2.404. PMID 10642580.
- Kampen GT, Stafford S, Adachi T, et al. (2000). "Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.". Blood 95 (6): 1911–7. PMID 10706854.
- Huber MA, Kraut N, Addicks T, Peter RU (2000). "Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation.". Biochem. Biophys. Res. Commun. 269 (2): 546–52. doi:10.1006/bbrc.2000.2287. PMID 10708591.
PDB gallery
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1eot: SOLUTION NMR STRUCTURE OF EOTAXIN, MINIMIZED AVERAGE STRUCTURE
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2eot: SOLUTION STRUCTURE OF EOTAXIN, AN ENSEMBLE OF 32 NMR SOLUTION STRUCTURES
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Cell signaling: cytokines
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By family |
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By function/
cell |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Increased serum levels of eotaxin/CCL11 in late-stage patients with bipolar disorder: An accelerated aging biomarker?
- Panizzutti B1, Gubert C2, Schuh AL3, Ferrari P4, Bristot G3, Fries GR2, Massuda R5, Walz J6, Rocha NP7, Berk M8, Teixeira AL7, Gama CS4.
- Journal of affective disorders.J Affect Disord.2015 Aug 15;182:64-9. doi: 10.1016/j.jad.2014.12.010. Epub 2015 Apr 14.
- BACKGROUND: Bipolar disorder (BD) is commonly comorbid with many medical disorders including atopy, and appears characterized by progressive social, neurobiological, and functional impairment associated with increasing number of episodes and illness duration. Early and late stages of BD may present
- PMID 25973785
- Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample.
- Cunha GR1,2,3, Asevedo E1,2,3, Mansur RB1,2, Zugman A1,2,3, Pan PM1,2,3, Gadelha A1,2,3, Belangero SI1,3, Rizzo LB3, Coelho R4,5, Stertz L6,7, Cogo-Moreira H3, Grassi-Oliveira R1,4,5, Teixeira AL8, Kauer-Sant'Anna M6, Mari JJ1,2,3,9, Miguel EC1,9,10, Bressan RA1,2,3,9, Brietzke E1,2,3.
- Acta psychiatrica Scandinavica.Acta Psychiatr Scand.2015 Jul 3. doi: 10.1111/acps.12453. [Epub ahead of print]
- OBJECTIVE: To investigate the association between peripheral biomarkers and child psychopathology in a large community sample.METHOD: A total of 625 aged 6- to 13-year old subjects were recruited from a community school-based study. Psychopathology was assessed using the Child Behaviour Checklist (C
- PMID 26139469
- ASSOCIATION BETWEEN AQUEOUS HUMOR CXC MOTIF CHEMOKINE LIGAND 13 LEVELS AND SUBFOVEAL CHOROIDAL THICKNESS IN NORMAL OLDER SUBJECTS.
- Nomura Y1, Takahashi H, Fujino Y, Kawashima H, Yanagi Y.
- Retina (Philadelphia, Pa.).Retina.2015 Jun 26. [Epub ahead of print]
- PURPOSE: To investigate the association of subfoveal choroidal thickness with intraocular inflammatory cytokines and chemokines.METHODS: The subjects consisted of 76 eyes of consecutive cataract patients at the Japan Community Health Care Organization Tokyo Shinjuku Medical Center between September
- PMID 26121407
Japanese Journal
- Eosinophils facilitate antigen-specific T-cell proliferation and aggravate antigen-induced arthritis.
- Saika Taro
- Kawasaki medical journal 40(1), 13-22, 2014
- … We also analyzed the gene expression of pro-inflammatory cytokines (IL-1β, IL-6, TNFα , and IL-17 ), Th1/Th2 cytokine (IFNγ and IL-13 ), and mediators that increase eosinophils (IL-5, IL-33, GM-CSF, CCL11, CCL24, CCL26, and RANTES ) in the synovium of the knee joints. …
- NAID 110009807868
- 新生児乳児消化管アレルギー : その粘膜病変について
- 大塚 宜一
- 日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology 27(1), 79-85, 2013-03-20
- NAID 10031163616
- 新生児乳児消化管アレルギー―その粘膜病変について―
- 大塚 宜一
- 日本小児アレルギー学会誌 27(1), 79-85, 2013
- … これらの粘膜を用い炎症性シグナル分子の発現をmicroarrayで網羅的に検討したところCCL11(eotaxin-1)やCXCL-13の発現亢進を認めた.特に好酸球浸潤と関連の深いCCL11の発現は新生児期に,リンパ濾胞増殖因子であるCXCL13の発現は乳児期により強く発現しており,新生児期のより重篤な好酸球浸潤と乳児期のより強いリンパ濾胞増殖性変化を反映していると考える.一方,好酸球性食道炎で求められるよう …
- NAID 130004504330
Related Links
- Complete information for CCL11 gene (protein-coding), chemokine (C-C motif) ligand 11, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Genomic ...
- CCL11/Eotaxin: Products Eotaxin is a potent eosinophil chemoattractant that is a member of the CC chemokine subfamily of inflammatory and immunoregulatory cytokines. At the protein sequence level, mature mouse Eotaxin is ...
Related Pictures
★リンクテーブル★
[★]
- 英
- eotaxin
- 同
- CCL11、エオタクシン
- 好酸球の遊走にかかわる
- 上皮から分泌? (BPT.491)
-eotaxin
[★]
- 同
- CCL11
- 同
- CCL11
[★]
セファクロル cefaclor