Cペプチド、CPR

WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein

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carbonの化学記号
cesiumの化学記号
cadmiumの化学記号

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1. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure
2. 膵ポリペプチド、ペプチドYY、およびニューロペプチドY pancreatic polypeptide peptide yy and neuropeptide y
3. 非心不全下におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in non heart failure settings
4. 臨床的に有用な生物学的マーカーによる関節リウマチの診断および転帰評価 clinically useful biologic markers in the diagnosis and assessment of outcome in rheumatoid arthritis
5. 2型糖尿病治療のためのGlucagon-like peptide-1受容体拮抗剤 glucagon like peptide 1 receptor agonists for the treatment of type 2 diabetes mellitus

English Journal

Association between skeletal muscle mass and insulin secretion in patients with type 2 diabetes mellitus.

Shishikura K1, Tanimoto K, Sakai S, Tanimoto Y, Terasaki J, Hanafusa T.Author information 1Department of Internal Medicine (I), Osaka Medical College, Takatsuki 569-8686, Japan.AbstractRecent research has indicated a relationship between skeletal muscle mass and insulin resistance in patients with type 2 diabetes mellitus (T2DM). However, no study has examined the relationship between skeletal muscle mass and insulin secretion in patients with Japanese T2DM. This study aimed to fill this research gap by investigating the relationship between skeletal muscle mass and clinical parameters of T2DM with special reference to the effect of sex or age on the relationship. We examined 138 consecutive T2DM patients who presented at a single center. Anthropomorphic measurement was conducted and skeletal muscle mass was determined by bioelectrical impedance analysis for calculating skeletal muscle index (SMI) as the ratio of appendicular muscle mass (AMM) to total body weight. Fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) were levels, and values of stimulated C-peptide immunoreactivity (CPR) were determined by glucagon stimulation testing. Statistical analysis showed that AMM was negatively correlated with age in T2DM patients, whereas SMI had no correlation with either FPG or HbA1c levels. On the other hand, SMI was found to be negatively correlated with the log-transformed stimulated CPR values in male patients <65 years (r = -0.40, p < 0.05) and in female patients <65 years (r = -0.40, p < 0.05). The results of multivariate analysis suggest a strong association between the log-transformed stimulated CPR value and SMI. These findings indicate that increased endogenous insulin secretion is associated with lower skeletal muscle mass in T2DM patients who are <65 years of age.
Endocrine journal.Endocr J.2014 Mar 30;61(3):281-7. Epub 2014 Jan 10.
Recent research has indicated a relationship between skeletal muscle mass and insulin resistance in patients with type 2 diabetes mellitus (T2DM). However, no study has examined the relationship between skeletal muscle mass and insulin secretion in patients with Japanese T2DM. This study aimed to fi
PMID 24420336

Lower beta cell function relates to sustained higher glycated albumin to glycated hemoglobin ratio in Japanese patients with type 2 diabetes.

Saisho Y1, Tanaka K, Abe T, Kawai T, Itoh H.Author information 1Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.AbstractThe aim of this study was to clarify the relationship between baseline beta cell function and future glycated albumin (GA) to glycated hemoglobin ratio (GA/HbA1c) in patients with type 2 diabetes. In our retrospective cohort, 210 type 2 diabetic patients who had been admitted to our hospital and in whom HbA1c and GA had been measured at baseline and 2 years after admission were included in this study. Baseline beta cell function was assessed by postprandial C-peptide immunoreactivity index (PCPRI) during admission. With intensification of treatment during admission, HbA1c and GA were significantly decreased 1 year and 2 years after admission. While baseline HbA1c was not significantly correlated with HbA1c after 2 years, baseline GA/HbA1c was strongly correlated with GA/HbA1c after 2 years (r = 0.575, P <0.001). When the patients were divided into two groups according to median PCPRI, patients with low PCPRI showed higher GA/HbA1c both at baseline and after 2 years compared to those with high PCPRI. There was a significant negative correlation between PCPRI and GA/HbA1c after 2 years (r = -0.379, P <0.001). Multiple regression analysis revealed that PCPRI was an independent predictor of GA/HbA1c after 2 years. In conclusion, our findings suggest that lower beta cell function is associated with sustained higher GA/HbA1c ratio in patients with type 2 diabetes.
Endocrine journal.Endocr J.2014;61(2):149-57. Epub 2013 Nov 9.
The aim of this study was to clarify the relationship between baseline beta cell function and future glycated albumin (GA) to glycated hemoglobin ratio (GA/HbA1c) in patients with type 2 diabetes. In our retrospective cohort, 210 type 2 diabetic patients who had been admitted to our hospital and in
PMID 24212881

The proinsulin/insulin (PI/I) ratio is reduced by postprandial targeting therapy in type 2 diabetes mellitus: a small-scale clinical study.

Ohkura T1, Inoue K, Fujioka Y, Nakanishi R, Shiochi H, Sumi K, Yamamoto N, Matsuzawa K, Izawa S, Ohkura H, Kato M, Yamamoto K, Taniguchi S.Author information 1Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine, Yonago, Tottori, Japan. ohkura@med.tottori-u.ac.jp.AbstractBACKGROUND: An elevated PI/I ratio is attributable to increased secretory demand on β-cells. However, the effect of postprandial targeting therapy on proinsulin level is unknown. We evaluated the metabolic effect of glinide and sulfonylurea (SU) using the meal tolerance test (MTT).
BMC research notes.BMC Res Notes.2013 Nov 11;6:453. doi: 10.1186/1756-0500-6-453.
BACKGROUND: An elevated PI/I ratio is attributable to increased secretory demand on β-cells. However, the effect of postprandial targeting therapy on proinsulin level is unknown. We evaluated the metabolic effect of glinide and sulfonylurea (SU) using the meal tolerance test (MTT).METHODS: MTT was
PMID 24215809

Japanese Journal

Evaluation of Insulin Secretion and Sensitivity in a Patient with Slowly Progressive Type 1 Diabetes Mellitus

Ishizuka Toshiharu,Tokuyama Yoshiharu,Kanatsuka Azuma
Internal Medicine 52(24), 2777-2780, 2013
… His body mass index remained at approximately 22, while his serum C-peptide immunoreactivity level gradually decreased. …
NAID 130003383747

Slowly Progressive Type 1 Diabetes Treated with Metformin for Five Years after Onset

Hirata Takumi,Shimada Akira,Morimoto Jiro,Maruyama Taro
Internal Medicine 52(23), 2635-2637, 2013
… At SPIDDM diagnosis, he was in a non-insulin-dependent state, with a fasting serum C-peptide immunoreactivity level of 2.5 ng/mL. …
NAID 130003383733

Rapid Amelioration of Hyperglycemia Facilitated by Dasatinib in a Chronic Myeloid Leukemia Patient with type 2 Diabetes Mellitus

Ono Keiko,Suzushima Hitoshi,Watanabe Yuko,Kikukawa Yoshitaka,Shimomura Taizou,Furukawa Noboru,Kawaguchi Tatsuya,Araki Eiichi
Internal Medicine 51(19), 2763-2766, 2012
… Meanwhile, the fasting C-peptide immunoreactivity increased two-fold, suggesting that dasatinib facilitated the recovery of insulin production. …
NAID 130002062048