WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

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(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
女性の話術芸人 =diseur
病気にかかった / 病的な,不健全な(morbid)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/04 17:26:25」(JST)

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Not to be confused with Scleroderma.

Scleredema, also known as Buschke disease, scleredema of Buschke, and scleredema adultorum,^[1]^[2] is a rare, self-limiting, skin condition defined by progressive thickening and hardening of the skin, usually on the areas of the upper back, neck, shoulders and face.^[3] The skin may also change color to red or orange. The disease was discovered by Abraham Buschke. Although the cause of scleredema is unknown, it is usually associated with a disease, usually diabetes,^[4] a viral illness or strep throat.^[5] It is usually not fatal, but it may cause death if the disease spreads to the internal organs.^[3] It may also cause an infection.^[5]

Diagnosis

The scleredema is usually proposed as a diagnosis based on the appearance of the skin and the patient's medical history. To confirm the diagnosis, the doctor performs a skin biopsy, in which hematoxylin and eosin staining will show a thick reticular dermis with thick collagen bundles separated by clear spaces.^[6] The patient's blood may be examined for diseases that may appear after the onset of symptoms, such as multiple myeloma.^[5]

Treatment

Although many types of medications have been tried as treatments, none of them have been proven effective in treating scleredema. Those treatments, such as corticosteroids, may benefit the patient, but will not cure their condition. If the affected area is infected, it is usually treated immediately. The symptoms of the condition usually resolve within six months to two years after onset. However, patients whose condition was associated to diabetes may suffer for longer periods of time.^[5]

Myocarditis resulting as a complication from the disease has been successfully treated with penicillin and steroids.^[7]

References

^ Turchin I, Adams SP, Enta T (September 2003). "Dermacase. Scleredema adultorum, or Bushke disease". Can Fam Physician 49: 1089, 1093. PMC 2214291. PMID 14526859. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2214291.
^ Pegum JS (June 1972). "Scleredema of Buschke". Proc. R. Soc. Med. 65 (6): 528. PMC 1643957. PMID 5044976. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1643957.
^ ^a ^b "Scleredema". http://emedicine.medscape.com/article/1066175-overview. Retrieved 2009-05-18.
^ Meguerditchian, C; Jacquet P, Béliard S et al. (November 2006). "Scleredema adultorum of Buschke: an under recognized skin complication of diabetes". Diabetes and Metabolism 32 (5): 481–484. DOI:10.1016/S1262-3636(07)70307-5. PMID 17110904. http://www.em-consulte.com/article/80515.
^ ^a ^b ^c ^d "Scleredema". http://rarediseases.about.com/od/rarediseasess/a/scleredema.htm. Retrieved 2009-05-18.
^ Schmults CA (October 2003). "Scleredema". Dermatol. Online J. 9 (4): 11. PMID 14594584. http://dermatology.cdlib.org/94/NYU/Jan2002/6.html.
^ "Buschke's Sclerema with right-sided heart failure.". http://content.karger.com/ProdukteDB/produkte.asp?Doi=173618. Retrieved 2009-05-18.

UpToDate Contents

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English Journal

Complementarity of visual and voxel-based FDG-PET analysis to detect MCI-like hypometabolic pattern in elderly patients with hypertension and isolated memory complaints.

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Recognition memory span in autopsy-confirmed Dementia with Lewy Bodies and Alzheimer's Disease.

Salmon DP1, Heindel WC2, Hamilton JM3, Vincent Filoteo J4, Cidambi V3, Hansen LA5, Masliah E5, Galasko D6.
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Neuropsychological tests for predicting cognitive decline in older adults.

Baerresen KM1,2, Miller KJ1, Hanson ER3, Miller JS4, Dye RV1, Hartman RE3, Vermeersch D3, Small GW1.
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SUMMARY Aim: To determine neuropsychological tests likely to predict cognitive decline.METHODS: A sample of nonconverters (n = 106) was compared with those who declined in cognitive status (n = 24). Significant univariate logistic regression prediction models were used to create multivariate logi
PMID 26107318

Japanese Journal

Bowen 様丘疹症および疣状癌 : 概念と病態

江川清文
Skin cancer : official organ of the Japanese Society for Skin Cancer = 皮膚悪性腫瘍研究会機関誌 25(3), 300-307, 2011-02-28
Bowen様丘疹症（bowenoid papulosis：BP）は，臨床的には良性であるが病理組織学的にBowen病様の異型を認める，外陰・肛門部の皮膚・粘膜に生じる単発～多発性の色素斑ないし表面平滑な丘疹である。HPV16/18をはじめとするハイリスク粘膜型HPV感染症であることが確立された疾患である。　一方疣状癌（verrucous carcinoma：VC）は，口腔粘膜，外陰部，足底などに好 …
NAID 10030441568

Clinical, histological and genetic investigation of Buschke-Fischer-Brauer's disease in Tunisian families

BCHETNIA Mbarka,CHARFEDDINE Cherine,KASSAR Selma,HANCHI Imen,TOUNSI-GUETTITI Haifa,REBAI Ahmed,DHAHRI-BEN OSMAN Amel,KUBISCH Christian,ABDELHAK Sonia,BOUBAKER Samir,MOKNI Mourad
Journal of dermatological science 54(1), 54-56, 2009-04-01
NAID 10025333237

Buschke-Loewenstein腫瘍の2例

工藤治,藤井浩,近藤猪一郎
泌尿器科紀要 30(2), 217-222, 1984-02
… We report two cases of Buschke-Lowenstein Tumor on 39- and 55-year-old males. … Pathological diagnosis was Buschke-Lowenstein tumor. … Our two patients are alive with no evidence of disease after 10 years. … Pathological and clinical problems of Buschke-Lowenstein tumor were discussed by review of the literature. …
NAID 120002158662