ブレンナー腫瘍
WordNet
- an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/26 15:36:31」(JST)
[Wiki en表示]
| Brenner tumor |
| Classification and external resources |
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A Brenner tumour of ovary (gross image).
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| ICD-9 |
220 |
| ICD-O: |
9000 |
| DiseasesDB |
33431 |
| MeSH |
D001948 |
Brenner tumors are uncommon tumours that are part of the surface epithelial-stromal tumor group of ovarian neoplasms.
The majority of these tumours are benign. However, they can be malignant.[1]
They are most frequently found as incidental findings[2] on pelvic examination or at laparotomy.
Brenner tumours very rarely can occur in other locations, including testis.[3]
Contents
- 1 Presentation
- 2 Diagnosis
- 3 Similar conditions
- 4 Eponym
- 5 Additional images
- 6 References
- 7 External links
Presentation
On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumours can vary in size from less than 1 centimetre (0.39 in) to 30 centimetres (12 in). Borderline and malignant Brenner tumours are possible but each are rare.
Diagnosis
Micrograph of a
Brenner tumour. H&E stain.
High magnification micrograph of a
Brenner tumour showing the characteristic
coffee bean nuclei. H&E stain.
Histologically, there are nests of transitional-type epithelial cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma.
Similar conditions
Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour.
Eponym
It is named for Fritz Brenner, who characterized it in 1907.[4] The term "Brenner tumor" was first used by Robert Meyer, in 1932.[5]
Additional images
-
Micrograph of a Walthard cell nest, the entity Brenner tumours are thought to arise from. H&E stain.
References
- ^ Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B (2005). "Malignant Brenner tumour--a case report". Indian J Pathol Microbiol 48 (2): 251–2. PMID 16758686.
- ^ Green GE, Mortele KJ, Glickman JN, Benson CB (2006). "Brenner tumors of the ovary: sonographic and computed tomographic imaging features". J Ultrasound Med 25 (10): 1245–51; quiz 1252–4. PMID 16998096.
- ^ Caccamo D, Socias M, Truchet C (1991). "Malignant Brenner tumor of the testis and epididymis". Arch. Pathol. Lab. Med. 115 (5): 524–7. PMID 2021324.
- ^ Lamping JD, Blythe JG (1977). "Bilateral Brenner tumors: a case report and review of the literature". Hum. Pathol. 8 (5): 583–5. doi:10.1016/S0046-8177(77)80117-2. PMID 903146.
- ^ Philipp, Elliot Elias; O'Dowd, Michael J. (2000). The history of obstetrics and gynaecology. Carnforth, Lancs: Parthenon. p. 586. ISBN 1-85070-040-0.
External links
- "Brenner tumour". Medcyclopaedia. GE. Archived from the original on 2012-02-05.
- Histology at University of Utah
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Connective/soft tissue tumors and sarcomas (ICD-O 8800–9059) (C45–C49/D17–D21, 171/214–215)
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| Not otherwise specified (8800–8809) |
- Soft-tissue sarcoma
- Desmoplastic small-round-cell tumor
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| Connective tissue neoplasm |
| Fibromatous (8810–8839) |
| Fibroma/fibrosarcoma: |
- Dermatofibrosarcoma protuberans
- Desmoplastic fibroma
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|
| Fibroma/fibromatosis: |
- Aggressive infantile fibromatosis
- Aponeurotic fibroma
- Collagenous fibroma
- Diffuse infantile fibromatosis
- Familial myxovascular fibromas
- Fibroma of tendon sheath
- Fibromatosis colli
- Infantile digital fibromatosis
- Juvenile hyaline fibromatosis
- Plantar fibromatosis
- Pleomorphic fibroma
- Oral submucous fibrosis
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|
| Histiocytoma/histiocytic sarcoma: |
- Benign fibrous histiocytoma
- Malignant fibrous histiocytoma
- Atypical fibroxanthoma
- Solitary fibrous tumor
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|
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| Myxomatous (8840–8849) |
- Myxoma/myxosarcoma
- Cutaneous myxoma
- Superficial acral fibromyxoma
- Angiomyxoma
- Ossifying fibromyxoid tumour
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|
| Fibroepithelial (9000–9039) |
- Brenner tumour
- Fibroadenoma
- Phyllodes tumor
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| Synovial-like (9040–9049) |
- Synovial sarcoma
- Clear-cell sarcoma
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|
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| Lipomatous (8850–8889) |
- Lipoma/liposarcoma
- Myelolipoma
- Myxoid liposarcoma
- PEComa
- Chondroid lipoma
- Intradermal spindle cell lipoma
- Pleomorphic lipoma
- Lipoblastomatosis
- Spindle cell lipoma
- Hibernoma
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| Myomatous (8890–8929) |
| general: |
|
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| smooth muscle: |
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| skeletal muscle: |
- Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma
- Alveolar rhabdomyosarcoma
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- Leiomyoma
- Angioleiomyoma
- Angiolipoleiomyoma
- Genital leiomyoma
- Leiomyosarcoma
- Multiple cutaneous and uterine leiomyomatosis syndrome
- Multiple cutaneous leiomyoma
- Neural fibrolipoma
- Solitary cutaneous leiomyoma
- STUMP
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|
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| Complex mixed and stromal (8930–8999) |
- Adenomyoma
- Pleomorphic adenoma
- Mixed Müllerian tumor
- Mesoblastic nephroma
- Wilms' tumor
- Malignant rhabdoid tumour
- Clear-cell sarcoma of the kidney
- Hepatoblastoma
- Pancreatoblastoma
- Carcinosarcoma
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| Mesothelial (9050–9059) |
- Mesothelioma
- Adenomatoid tumor
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see also Template:Connective tissue
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anat (h/n, u, t/d, a/p, l)/phys/devp/hist
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noco (m, s, c)/cong (d)/tumr, sysi/epon, injr
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Tumors: female urogenital neoplasia (C51–C58/D25–D28, 179–184/218–221)
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| Adnexa |
| Ovaries |
Glandular and epithelial/
surface epithelial-
stromal tumor |
| CMS: |
- Ovarian serous cystadenoma
- Mucinous cystadenoma
- Cystadenocarcinoma
- Papillary serous cystadenocarcinoma
- Krukenberg tumor
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- Endometrioid tumor
- Clear-cell ovarian carcinoma
- Brenner tumour
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| Sex cord-gonadal stromal |
- Leydig cell tumour
- Sertoli cell tumour
- Sertoli-Leydig cell tumour
- Thecoma
- Granulosa cell tumour
- Luteoma
- Sex cord tumour with annular tubules
- Steroid cell tumor (NOS)
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| Germ cell |
- Dysgerminoma
- Nongerminomatous
- Embryonal carcinoma
- Endodermal sinus tumor
- Gonadoblastoma
- Teratoma/Struma ovarii
- Choriocarcinoma
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| Fibroma |
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| Fallopian tube |
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| Uterus |
| Myometrium |
- Uterine fibroids/leiomyoma
- Leiomyosarcoma
- Adenomyoma
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| Endometrium |
- Endometrioid tumor
- Uterine papillary serous carcinoma
- Clear cell carcinoma
- Endometrial intraepithelial neoplasia
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| Cervix |
- Cervical intraepithelial neoplasia
- SCC
- Glassy cell carcinoma
- Villoglandular adenocarcinoma
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| Placenta |
- Choriocarcinoma
- Gestational trophoblastic disease
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| General |
- Uterine sarcoma
- Mixed Müllerian tumor
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| Vagina |
- SCC
- Botryoid rhabdomyosarcoma
- Clear cell adenocarcinoma of the vagina
- Vaginal intraepithelial neoplasia
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| Vulva |
- SCC
- Melanoma
- Papillary hidradenoma
- Extramammary Paget's disease
- Vulvar intraepithelial neoplasia
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noco/cong/npls, sysi/epon
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proc/asst, drug (G1/G2B/G3CD)
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UpToDate Contents
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English Journal
- Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.
- Itsumi M1, Inoue S1, Elia AJ1, Murakami K1, Sasaki M1, Lind EF1, Brenner D1,2, Harris IS1, Chio II1, Afzal S1,3, Cairns RA1, Cescon DW1, Elford AR1, Ye J1, Lang PA1,4,5, Li WY1, Wakeham A1, Duncan GS1, Haight J1, You-Ten A1, Snow B1, Yamamoto K1, Ohashi PS1,3, Mak TW1,3.
- Cell death and differentiation.Cell Death Differ.2015 Nov;22(11):1837-45. doi: 10.1038/cdd.2015.38. Epub 2015 Apr 17.
- Isocitrate dehydrogenase-1 (Idh1) is an important metabolic enzyme that produces NADPH by converting isocitrate to α-ketoglutarate. Idh1 is known to reduce reactive oxygen species (ROS) induced in cells by treatment with lipopolysaccharide (LPS) in vitro. Here, we used Idh1-deficient knockout (Idh1
- PMID 25882048
- Overexpression of SIX1 is an independent prognostic marker in stage I-III colorectal cancer.
- Kahlert C1, Lerbs T1, Pecqueux M1, Herpel E2, Hoffmeister M3, Jansen L3, Brenner H3, Chang-Claude J4, Bläker H5, Kloor M2, Roth W2, Pilarsky C1, Rahbari NN1, Schölch S1, Bork U1, Reissfelder C1, Weitz J1, Aust D6, Koch M1.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 Nov 1;137(9):2104-13. doi: 10.1002/ijc.29596. Epub 2015 May 21.
- Epithelial-to-mesenchymal transition (EMT) contributes significantly to tumor progression and metastasis. The assessment of EMT-associated transcription factors could be a promising approach to identify biomarkers and potential therapeutic targets in colorectal cancer. In our study, we focused on th
- PMID 25951369
- Tumor volume in insignificant prostate cancer: Increasing the threshold is a safe approach to reduce over-treatment.
- Ting F1,2, van Leeuwen PJ1,2, Delprado W3, Haynes AM2, Brenner P1, Stricker PD1,2.
- The Prostate.Prostate.2015 Nov;75(15):1768-73. doi: 10.1002/pros.23062. Epub 2015 Aug 18.
- BACKGROUND: There are conflicting results in the literature regarding the tumor volume (TV) threshold that defines insignificant prostate cancer (PCa). In this study, we retrospectively evaluate the association of an increasing TV with biochemical recurrence (BCR) following radical prostatectomy (RP
- PMID 26282713
Japanese Journal
- 症例 子宮漿膜下筋腫と鑑別が困難であった転移性平滑筋腫と考えられた1例
- Recent concepts of ovarian carcinogenesis: type I and type II.
- Koshiyama Masafumi,Matsumura Noriomi,Konishi Ikuo
- BioMed research international 2014, 2014
- … Other theories of their origin include mucinous metaplasia of surface epithelial inclusions, endometriosis, and Brenner tumors. … Low grade serous carcinomas are thought to evolve in a stepwise fashion from benign serous cystadenoma to a serous borderline tumor (SBT). …
- NAID 120005455993
- 症例 8年の経過観察中に悪性化を認めたBrenner腫瘍の1例 (特集 腹部の最新画像情報2013)
Related Links
- A Brenner tumor of the ovary is a small, firm, smooth and solid growth (tumor) on the ovary. Brenner tumors of the ovary usually do not cause symptoms. [1] [2] [3] Approximately 2% of all ovarian tumors are Brenner ...
- A Brenner tumour is an uncommon surface epithelial tumour of the ovary. It was originally known as a transitional cell tumour due to its histological similarity to the urothelium. Brenner tumours account for up to 3.2% of ovarian ...
Related Pictures
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悪性ブレンナー腫瘍
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