WordNet

a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
dress in a bonnet
a hat tied under the chin (同)poke bonnet
a cone-shaped chuck used for holding cylindrical pieces in a lathe (同)collet chuck
a band or collar that holds an individual stone in a jewelry setting
a city in western Germany on the Rhine River; was the capital of West Germany between 1949 and 1989

PrepTutorEJDIC

(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
『ボンネット』(婦人・子共用のひもをあご下で結ぶ大きな帽子) / 《英》ボンネット(自動車の前方機関部のおおい;《米》hood)
ボン(西ドイツの首都)

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1. 総動脈幹 truncus arteriosus
2. 幻視患者へのアプローチ approach to the patient with visual hallucinations
3. 視覚的な解放性幻視（シャルル・ボネ症候群） visual release hallucinations charles bonnet syndrome
4. 思春期および成人における非てんかん性痙攣疾患 nonepileptic paroxysmal disorders in adolescents and adults
5. 巨細胞（側頭）動脈炎の臨床症状 clinical manifestations of giant cell temporal arteritis

English Journal

Prasugrel monitoring and bleeding in real world patients.

Cayla G1, Cuisset T, Silvain J, O'Connor SA, Kerneis M, Castelli C, Quilici J, Bonnet JL, Alessi MC, Morange PE, Collet JP, Montalescot G.Author information 1Institut de Cardiologie, INSERM UMRS937, Pitié-Salpêtrière Hospital, Université Paris 6, Paris, France.AbstractThe aim of this study was to evaluate platelet reactivity and 30-day bleeding events in patients treated with prasugrel 10 mg after acute coronary syndromes. A total of 444 patients with acute coronary syndromes treated with percutaneous coronary intervention and prasugrel 10 mg/day were monitored by measurement of the vasodilator-stimulated phosphoprotein (VASP) index 2 to 4 weeks after hospital discharge. Platelet reactivity was also assessed using the VerifyNow P2Y(12) assay and light transmission aggregometry. Bleeding events (per the Bleeding Academic Research Consortium [BARC] definition) and ischemic events (death, myocardial infarction, and definite stent thrombosis) were collected over 30 days of follow-up. Two thirds of the patients presented with ST-segment elevation myocardial infarctions, 28.8% had diabetes, and 12.4% were aged >75 years. High on-treatment platelet reactivity according to 3 prespecified definitions (VASP index ≥ 50%, platelet reactivity ≥ 235 P2Y(12) reaction units, and residual platelet reactivity ≥ 46.2%) was found in 6.8%, 3.4%, and 3.2% of patients, respectively. Obesity (body mass index >30 kg/m(2)) and multivessel disease were the only independent factors associated with high on-treatment platelet reactivity (p = 0.006 and p = 0.045, respectively). At 30 days, there was no major bleeding complication (BARC grade 3 or 5), and 1.6% of patients had recurrent ischemic events. Nuisance bleeding (BARC grade 1) and minor bleeding (BARC grade 2) occurred in 14.2% (n = 63) and 2.5% (n = 11) of patients, respectively, but were not predicted by VASP index. In conclusion, patients with acute coronary syndromes receiving maintenance doses of prasugrel have low rates of HPR and ischemic events within the first month. Minor or minimal bleeding is frequent, but not major bleeding. VASP was poorly correlated with the risk for minor or minimal bleeding.
The American journal of cardiology.Am J Cardiol.2013 Jan 1;111(1):38-44. doi: 10.1016/j.amjcard.2012.08.043. Epub 2012 Oct 2.
The aim of this study was to evaluate platelet reactivity and 30-day bleeding events in patients treated with prasugrel 10 mg after acute coronary syndromes. A total of 444 patients with acute coronary syndromes treated with percutaneous coronary intervention and prasugrel 10 mg/day were monitored b
PMID 23040597

Intravenous enoxaparin or unfractionated heparin in primary percutaneous coronary intervention for ST-elevation myocardial infarction: the international randomised open-label ATOLL trial.

Montalescot G1, Zeymer U, Silvain J, Boulanger B, Cohen M, Goldstein P, Ecollan P, Combes X, Huber K, Pollack C Jr, Bénezet JF, Stibbe O, Filippi E, Teiger E, Cayla G, Elhadad S, Adnet F, Chouihed T, Gallula S, Greffet A, Aout M, Collet JP, Vicaut E; ATOLL Investigators.Collaborators (174)Montalescot G, Cohen M, Goldstein P, Huber K, Pollack C, Vicaut E, Zeymer U, Cohen A, Cucherat M, Gitt A, Bellemain-Appaix A, Boccara F, Gournay O, Philippe F, Sabouret P, Dumaine R, Reza A, Gallula P, Gallois V, Paulsrud S, Bertin B, Brugier D, Vignolles N, Viaud-Courrèges M, Jouis V, Huber, Unger, Nürnberg, Geppert, Jarai, Bruno, Freynhofer, Leherbauer, Pavlovic, Vogel, Leisch, Grund, Steinwender, Hofmann, Kammler, Hönig, Kerschner, Kypta, Weidinger, Jungbauer, Krutisch, Benzer, Montalescot, Collet, Silvain, Barthélémy, Beygui, Ecollan, Henry, Dillinger, Broche, Gallula, Greffet, Carli, Spaulding, Varenne, Jegou, Marque, Steg, Danchin, Durand, Margenet, Combes, Le Roux, Teiger, Bamabas, Adnet, Lapostolle, Payot, Pouges, Briole, Garrigue, Lardoux, Goube, Toussaint, Berthier, Elhadad, Cohen, Domniez, Foucher, Sfaxi, Stibbe, Porcher, Cuvier, Duclos, Belhamiche, Gelée, Dupas, Funck, Guillard, Paganelli, Auffray, Bonnet, Cuisset, Wittenberg, Barberon, Pansieri, Barnay, Ledermann, Cayla, Schmutz, Bertinchant, Messner-Pellenc, Bénezet, Assaf, de la Coussaye, Ducassé, Charpentier, Carrié, Thicoïpe, Chauveau, Coste, Leroux, Chouihed, Angioï, Marcon, Boulanger, Filippi, Mahe, Treuil, Boschat, Gilard, Le Breton, Courcoux, Mehu, Joseph, Goldstein, Asseman, Adriansen, Ennezat, Bauchart, Lablanche, Thuaire, Freysz, Avondo-Lofti, Cottin, Cabrita, Salengro, Jessen, Wolff, Jacquemin, Nallet, Cattan, Michaud, Zeymer, Zahn, Klein, Winkler, Schiele, Andresen, Hoffmann, Drogaris, Admovihadscho, Fischer, Axthelm, Schein, Funke, Girth, Hauber, Schmidt, Hanika, Heimann, Hauptmann, Gehrig, Cohen, Adams, Shamoon, Pennel, Montel.
Lancet.Lancet.2011 Aug 20;378(9792):693-703. doi: 10.1016/S0140-6736(11)60876-3.
BACKGROUND: Primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction has traditionally been supported by unfractionated heparin, which has never been directly compared with a new anticoagulant using consistent anticoagulation and similar antiplatelet strategies in both
PMID 21856483

Early versus delayed, provisional eptifibatide in acute coronary syndromes.

Giugliano RP1, White JA, Bode C, Armstrong PW, Montalescot G, Lewis BS, van 't Hof A, Berdan LG, Lee KL, Strony JT, Hildemann S, Veltri E, Van de Werf F, Braunwald E, Harrington RA, Califf RM, Newby LK; EARLY ACS Investigators.Collaborators (1063)Braunwald E, Giugliano RP, Califf RM, Harrington RA, Newby LK, White JA, Van de Werf F, Armstrong PW, Montalescot G, Veltri E, Hildemann S, Strony JT, Kilian A, Yang B, Gilbert J, Huber K, Aylward P, Labinaz M, Langer A, Tanguay JF, Widimsky P, Grande P, Lindroos M, Steg PG, Bode C, Zeymer U, Keltai M, Prabhakaran D, Lewis BS, Ardissino D, Van 't Hof A, White H, Atar D, Ruzyllo W, da Silva PC, Sulimov V, Dalby A, Betriu A, Mach F, James S, Fox K, Karsch K, Brogan G, Ferguson J, Gibler B, Herrmann H, Hochman J, Hoekstra J, Kleiman N, Ohman EM, O'Neill W, Pollack C Jr, Schweiger M, Newby LK, Harrington RA, Tricoci P, Berdan L, White J, Lee K, Leimberger J, Roe M, Montgomery D, Alexander J, Brennan M, Bushnell C, Chan M, Lopes R, Laskowitz D, Mahaffey K, Mehta R, Melloni C, Mills J, Oliveira G, Patel M, Petersen J, Piccini J, Shah B, Tricoci P, Wang T, Williams K, Wiviott S, Campbell C, Heath A, Weaver D, Alpert J, Cohen E, Faxon D, Fisher L, Verheugt F, Kunadian V, Zorkun C, Williams S, Biller L, Palmer A, Ogando K, Blank B, Newby K, Druken B, Malik A, Williams S, Cohen Y, Perez K, Kumar A, Thomas R, Singh V, Nelson M, Vora K, Vanover M, Metzger DC, Bessinger M, Chang M, Kiech J, Lui H, Holman L, Nygaard T, White J, Sharma M, Gibson T, Krucoff M, Powell M, Surmitis J, Gumm D, Godby D, Caulfield T, Dixon M, Mckendall G, Grogan M, Hodson R, Vassilaros A, Treasure C 2nd, Bales C, Mayer N, Stevens P, D'Urso M, DeRaad R, Khadra S, Peacock G, Nadar V, Darrow K, Chandler AB Jr, Easler P, Puri S, Lopez C, Coram R, Van Hoose B, Chandna H, Holly D, Mody F, Dranovskiy V, Chandrasekaran S, Kemp A, Martin T, Wells A, Miller G, Holt M, Brilakis E, Rangan B, Eaton G, Looney A, Hassinger N, Leone C, Singer A, Kidd J, Rivera E, Sutton M, Drenning D, Cooley T, Tolleson T, Rasor C, Harjai K, Hoey K, Jezior M, Young C, Lu D, Cieszkowski J, Tessmar C, Hindupur M, Eckert F, Bethea C, Fife B, Bissett J, Locke S, Kamalash M, Carlson K, Chandrashekhar Y, Tetrick L, Coram R, Schaffer L, D'Haem C, Zambon T, Forrest T, Barker B, Adjei A, Pulliam K, Gogia H, Kori S, Rivera E, Goad R, Khoury S, Edwards J, Dave R, McMullen S, Bhagwat R, DeLeon M, Arora U, Bolton J, Raisinghani A, Ghannadian B, Zenni M 2nd, Guimaraes K, Cebe J, Harrelson S, Chandna H, Holly D, De Lemos J, Pinkston K, Gory D, Butler D, Arnold A, Kappel D, Palazzo A, Tormey D, Perlman R, Palazzo D, Mayer T, Genova E, Sacchi T, Hammad E, Acheatel R, Biggers J, Fortuin D, Pfrommer J, Kelley M, Fettis C, Minor S, Shipwash T, Tucker K, Harp L, Wheeler K, Nieder S, Broderick G, Mohr R, Niederman A, Kellerman T, Muhlestein B, Briggs B, Birnbaum Y, Allen J, De Gregorio M, Baird C, Garg M, Ferguson M, Bryant F, Unks DM, Blakely J, Wassmer P, Duff R, Miller C, Triplett L, Lohrbauer LA, Bloom K, Gogia H, Kori S, Turk S, Fick S, Schreiter S, Mrozinski D, Omar B, Revere C, Strunk B, Watanabe D, French W, Barillas O, Shirwany A, Douglas L, Dimenna J, Waitkus C, Paulowski J, Amos M, Aji J, Ryan J, Loussararian A, Andreas G, Marsh R, Coombs A, Finney J, Duerr D, Patel D, Bolton J, Bikkina M, Turnbull K, Albirini A, Campbell T, Insel J, Johns M, Masroor M, Meadows C, Margolis J, Suarez H, Liu M, Khan W, Bittman M, Finney J, Saczynski J, Mego D, Thomas M, Jones J, Malone E, Le S, Fettis C, Alexander J, Genova E, Perez J, Addington J, Raveendran G, Engelbrecht R, Singh S, Sesing J, Casino WP, Ernest J, Zughaib M, Telck K, Bissett J, Kidd K, Levy P, Mango LM, McPherson J, Palevo G, Belknap M, Halbe S, Jafar Z, O'Brien P, Khoury S, Werner C, Shah R, Doman A, Bashir R, George C, Buchanan W, Bobek MB, Lieberman C, Williams M, Kontos M, Roach L, Williams G, McGuire J, Zhao D, Myers D, Tolerico P, Delio-Cox B, Levin H, Carle C, Mayor M, Humphreys R, Hotchkiss D, Farley A, Yasin M, Ahmad W, Lakkis N, Bobek J, Lee D, Grape J, Tolleson T, Rasor C, Mulumudi M, Covey M, Leimgruber P, Llewellyn C, Meengs M, Thomas K, Makam S, Smyth C, Chu A, Poremski K, Fintel D, Karpf E, Agarwal J, Manda S, Bhakta D, Abell T, Trageser T, Nahhas A, Winston N, Nahhas A, Winston N, Kesselbrenner M, Sayles K, Bethala V, Perkins T, Hui P, Bernier E, Levine M, Swanson MA, Saltiel F, Fanning G, Khosla S, Pivonka R, LaLonde T, Teller S, Goyal A, Spalding T, Masud AR, Giambra T, Correa L, Suarez H, Buergler J, Garcia M, Lancaster L, Johnston K, Saucedo J, Beard D, Lachterman B, Parks K, Ayres M, Rhule V, Dunne R, Mango LM, Shamoon F, Monel R, Sharma T, Paletta L, Lee B, Lavoie J, Bamdad P, Recker M, Karas S, Howard M, Panayiotou H, Sullivan P, Saha P, Bembridge D, Matheney R, Anthony M, Amidon T, Morris M, Andrea B, Schmida LS, Lurie M, Best K, McNabb L, Wilson D, Thai H, McArthur A, Sandhu L, Leone ML, Foster G, DeFehr S, Sun EL, Bornheimer J, Cohen J, Egbujiobi L, Betz D, Chilakamarri V, Schrader C, Berg W, Lawson K, Latief A, McGrew F, Rye D, Atassi K, Christy L, Karve M, Habetler T, Saltiel F, Fanning G, Nanna M, Diaz-Oliver L, Shapiro T, Sher L, Martin J, Pensyl C, Staniloae C, Hermance E, Cassavar D, Hoagland B, Kabour A, Neidhardt J, Takakuwa K, Grabin J, Humayun N, Appleton D, Shah P, Connors A, Kosinski E, Capasso M, Garratt K, Dalangin I, Suresh D, Pooja B, Chadow H, Hauptman R, Phillips W, Bilodeau T, Meyer T, Knott C, Browne K Jr, Matheny P, Klancke K, Bayer M, Stuckey T, Milks S, Grossman W, Pelchy P, Nelson C, Janet B, Parrott C, Cheryl F, Seaworth J, Primack D, Weaver T, Nyitray W, Antonescu A, Nyitray W, Antonescu A, Carr K, Peek M, Phillips P, Gray N, Patel J, Newell N, Acheatel R, Biggers J, Shammas N, Stoakes P, Dadkhah S, Fisch A, Friedman B, Bernhardt-Wimoski S, Hoff J, Stiles R, Tannenbaum M, Porter R, Tekler L, Stenstrom S, Chamernick C, Fry ET, Burkert M, Farah T, Harter C, Menapace F, Kleman M, Ledley G, Tobias SL, Hudock D, Suresh D, Pooja B, Perlman R, Palazzo D, Saint-Jacques H, Rivera J, Shani J, Gill A, Litt M, Tripp G, Rama P, DePauw J, Niederman A, Kellerman T, Phillips JW 3rd, Griswold M, Bode C, Schwab T, Darius H, Kuckuck A, Schunkert H, Lindemann C, Gottwik M, Zahn R, Werner G, Ferrar M, Zeymer U, Koet O, Strasser RH, Hofmann S, Felix SB, Mieske K, Heitzer T, Baldus S, Nienaber CA, Heider D, Brachmann J, Hoehn A, Klauss V, Baylacher M, Mudra H, Arnold M, Gross M, Gailani M, Willenbrock R, Desaga M, Desaga U, Jung W, Rillig A, Wiemer M, Wellmann B, Haase KK, Weller F, Schieffer B, Ritter B, Katus H, Giannitsis E, Kreuzer J, Nitsche K, Lewalter T, Remerie S, Appel K, Fugmann S, Hossmann V, Horlitz M, Hanefeld C, Khandanpour J, Buerke M, Koenig M, Hauptmann K, Gehrig T, Kasiske HP, Eggenkaemper M, vom Dahl J, Krug-Hoeren B, Lengfelder W, Duerrwald S, Schulze M, Gall K, Neuzner J, Schoebel WA, Simon R, Lins M, Kadel C, Rahn G, Hamann F, Pieper M, Schuster P, Hobbach H, Horacek T, Guenesli A, Lewis B, Yuval R, Uziel-Iunger K, Kracoff O, Roth A, Bogomonali N, Nikolsky E, Ben Zvi M, Rozenman Y, Logvinenko S, Guetta V, Rosenschein U, Harel S, Marmor A, Klutstein M, Rojanski A, Lotan H, Kreisberg B, Zahger D, Grosbard A, Senaratne M, Chanin S, Lutchmedial S, Fitzgerald F, Kornder J, Elliott H, Tanguay J, Caron M, Tymchak W, Harris L, Mukherjee A, Bozek B, Rupka D, Marchand C, Brossoit R, Peck C, Labinaz M, Shore N, Gosselin G, David M, Bata I, Hulan M, Wells C, Childs C, Habot J, McPherson C, Hilton D, Keith-Burgwin J, Pearce M, Janzen I, Van Kieu C, Carignan D, Kouz S, Roy M, Muzyka T, Prosser A, Turek M, Finnigan J, Doucet M, LaRiviere S, Vizel S, Markov G, Rose B, Rideout A, Aymong E, Grieve E, MacFadyen J, Naughton S, Clarke A, Marshall J, De Larochelliere R, Fournier R, Ervin F, Thiessen S, Huynh T, Boudreault C, Laramee P, Therrien D, Kokis A, Gagne G, Hatheway R, Wheatley M, Huber K, Jordanova N, Frank H, Thudt K, Marosi L, Brunner T, Pichler M, Kopp K, Slany J, Steger C, Stockenhuber F, Zenker G, Kaspar K, Brussee H, Zweiker R, Stark G, Meister E, Rainer W, Bernt H, Leisch F, Kammler J, Kypta A, Lenzhofer R, Wimmer F, Weihs W, Geyer G, Steg PG, Feldman L, Montalescot G, Collet J, Beygui F, Coisne D, Berger N, Ferrari E, Lanfranchi P, Khalife K, Ben Ahmed F, Beaufils P, Henry P, Bassand J, Schiele F, Allouch P, sur Seine N, Baron O, Gully C, Zupan M, Bronner F, Halaby AA, Alsagheer S, Dambrine P, Delarche N, Lasserre R, Bonnet P, Cheradame I, Barreau D, Dupont M, Boueri ZM, Bretelle C, Cabrol P, Poulard JE, Livarek D, Schwob J, Traisnel G, El Jarroudi M, Berland J, Kerkeni M, Puel J, Elbaz M, Haridas KK, Kumar S, Rao MB, Hiremath MS, Sinha N, Srivastav A, Kaul U, Gupta R, Mohanan PP, Preetha M, Parikh K, Shah H, Panwar RB, Chauhan BS, Chandra P, Saxena R, Kler TS, Basumatry S, Gil R, Gziut A, Ruzyllo W, Deptuch T, Kubik L, Tkaczewski K, Dubiel J, Mielecki W, Przewlocki T, Zalewski J, Ponikowski P, Powierza S, Musial W, Kuklinska A, Kleinrok A, Dudek J, Goch J, Kawinski J, Trusz-Gluza J, Wita K, Van 't Hof A, Koolen JJ, ten Berg JM, Stella PR, Dunselman PH, Van Boven A, Branny M, Sknouril L, Maly M, Alan D, Bocek P, Tauchman A, Stipal R, Pleva L, Groch L, Hormacek I, Kala P, Poloczek M, Coufal Z, Naplava R, Richter M, Ostransky J, Dvorak J, Jirmar R, Novobilsky K, Linhart A, Belohlavek J, Janek B, Burova N, Belekhov G, Gordeev I, Luchinkina E, Svistov A, Ryzhman N, Markov V, Repin A, Klein G, Kupriyanov A, Vishnevsky A, Kosicin D, Petrov A, Gusarova O, Rudnev D, Bykova N, Ardashev A, Shavarov A, Duda A, Kalugina O, Barbarash O, Berns S, Arutyunov G, Rozanov A, Kosmacheva E, Kruberg L, Boldueva S, Arkharov I, Kostenko V, Sapozhnikova I, Fomin I, Badin Y, Pershukov I, Moreva E, Shcherbak A, Voronina U, Baum S, Andryushina N, Chernyavsky A, Vereshchagin M, Ardissino D, Rolli A, Binetti G, De Ferrari G, Panigada S, Mos L, Vriz O, Moretti L, Zur G, Giagu P, Orlandi M, Tamburino C, Marenzi G, Marana I, Berni A, Marra S, Usmiani T, Percoco GF, Dalby A, Lock E, Mabin T, Roos J, Corbett C, Bodenstein J, Ebrahim I, Bobak C, Blomerus P, Badenhorst J, Mpe M, Darby S, Theron Hdu T, de Beer M, Tayob F, Belekhov G, Moccetti T, Rossi MG, Pieper M, Michel D, Keller P, Sigaud P, James S, Boden U, Lugnegard J, Ahlmark H, Erlinge D, Duckert A, Henareh L, Berglund M, Bang CH, Therneld H, Samad B, Larsdotter-Svensson T, Karlsson A, Grändås M, Karlsson J, Koch A, Swahn E, Logander E, Sarkar N, Hage C, Larsson L, Hammerman A, Romero J, Betriu A, Bosch X, Bordes Siscar P, Fernández Vazquez F, Sanchís J, Antorrena I, Suarez J, Balaguer Recena J, Hernández J, Moreu J, Bethencourt A, Macaya Miguel C, Atar D, Ytre-Arne K, Hysing J, Flagstad E, Eritsland J, Hoffmann P, Endresen K, Otterstad JE, Thybo NK, Kallhovd A, Omdal TR, Lutterbey G, Carrageta M, Vinhaf H, Ferreira J, Teles R, Providencia L, Monteiro P, da Silva PC, Diaz NC, Sim K, Tchai D, Zambahari R, Abdullah M, Chee K, Loke L, Ismail OB, Tan Saw Ean SN, El Allaf D, Gits F, Vincent M, Van Gils K, Dujardin K, Colpaert V, Lancellotti P, Celentano C, Renard D, De Velter I, Purnode P, Van Gils K, Kiss RG, Kiss N, Merkely B, Bárczi G, Edes I, Fülöp L, Lupkovics G, Papp E, White H, Cunningham L, Wong S, Caveney D, Hart H, McAnnalley G, Devlin GP, Low L, Wong A, Leow W, Tan H, Low M, Lee S, Kong S, Yu C, Yue M, Lindroos M, Järvensivu O, Groundstroem K, Koskinen R, Hartikainen J, Ollikainen H, Chew D, Edwards C, Rankin J, Ferguson L, Lehman R, Morrison H, Hill A, Conway B, Singh B, A'Campo M, Sonmez K, Yaymaci B, Kozan O, Akdeniz B, Ergene O, Yuksek U, Grande P, Galatius S, Jensen JS, Jensen T, Adgey J, Gammon B, Connolly D, Wtam Y, de Belder M, Radford L, Goode G.
The New England journal of medicine.N Engl J Med.2009 May 21;360(21):2176-90. doi: 10.1056/NEJMoa0901316. Epub 2009 Mar 30.
BACKGROUND: Glycoprotein IIb/IIIa inhibitors are indicated in patients with acute coronary syndromes who are undergoing an invasive procedure. The optimal timing of the initiation of such therapy is unknown.METHODS: We compared a strategy of early, routine administration of eptifibatide with delayed
PMID 19332455