BRCA2 gene

WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity.

Beltran H, Yelensky R, Frampton GM, Park K, Downing SR, Macdonald TY, Jarosz M, Lipson D, Tagawa ST, Nanus DM, Stephens PJ, Mosquera JM, Cronin MT, Rubin MA.SourceDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Medical College of Cornell University, New York, NY, USA.
European urology.Eur Urol.2013 May;63(5):920-6. doi: 10.1016/j.eururo.2012.08.053. Epub 2012 Sep 5.
BACKGROUND: Most personalized cancer care strategies involving DNA sequencing are highly reliant on acquiring sufficient fresh or frozen tissue. It has been challenging to comprehensively evaluate the genome of advanced prostate cancer (PCa) because of limited access to metastatic tissue.OBJECTIVE:
PMID 22981675

Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines.

Wark L, Novak D, Sabbaghian N, Amrein L, Jangamreddy JR, Cheang M, Pouchet C, Aloyz R, Foulkes WD, Mai S, Tischkowitz M.SourceThe Genomic Centre for Cancer Research and Diagnosis, Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Genes, chromosomes & cancer.Genes Chromosomes Cancer.2013 May;52(5):480-94. doi: 10.1002/gcc.22045. Epub 2013 Jan 23.
PALB2/FANCN is a BRCA1- and BRCA2-interacting Fanconi Anemia (FA) protein crucial for key BRCA2 genome caretaker functions. Heterozygous germline mutations in PALB2 predispose to breast cancer and biallelic mutations cause FA. FA proteins play a critical role in the telomere maintenance pathway, wit
PMID 23341105

Alterations in replication timing of cancer-related genes in malignant human breast cancer cells.

Fritz A, Sinha S, Marella N, Berezney R.SourceDepartment of Biological Sciences, University at Buffalo, State University of New York, Buffalo, New York 14260.
Journal of cellular biochemistry.J Cell Biochem.2013 May;114(5):1074-83. doi: 10.1002/jcb.24447.
The replication timing of nine genes commonly involved in cancer was investigated in the MCF10 cell lines for human breast cancer progression. Six of these nine genes are part of a constellation of tumor suppressor genes that play a major role in familial human breast cancer (TP53, ATM, PTEN, CHK2,
PMID 23161755

Spectra of BRCA1 and BRCA2 mutations in Korean patients with breast cancer : the importance of whole-gene sequencing : This article has been corrected since advance Online Publication, and a corrigendum is also printed in this issue

Jang Ja-Hyun,Lee Jeong Eon,Kwon Min-Jung [他],KI Chang-Seok,KIM Jong-Won,NAM Seok Jin,YANG Jung-Hyun
Journal of human genetics 57(3), 212-215, 2012-03-01
NAID 10030712167

Ileal Metastasis of Breast Cancer in a Patient with a BRCA2 Gene Mutation : Report of a Case

CHO DONG HUI,JEON YOUNG SAN,CHOI MIN-YOUNG,LEE SE KYUNG,KIM SANG MIN,HUR SUNG MO,KOO MIN YOUNG,BAE SOO YOUN,CHOE JUN-HO,KIM JUNG-HAN,KIM JEE SOO,NAM SEOK JIN,YANG JUNG-HYUN,LEE JEONG EON
Surgery today : the Japanese journal of surgery 41(12), 1665-1669, 2011-12-01
NAID 10030229947