出典: meddic

Brain-derived neurotrophic factor
brain-derived neurotrophic factor
Brain-derived neurotrophic factor

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/07 19:45:23」(JST)

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  • Delayed neuroprotection against cerebral ischemia reperfusion injury: putative role of BDNF and GSK-3β.
  • Taliyan R1, Ramagiri S1.
  • Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Aug;36(4):402-10. doi: 10.3109/10799893.2015.1108338. Epub 2015 Nov 10.
  • AIM: Numerous studies have demonstrated the possible neuroprotective role of lithium treatment against neurological disorders. However, the role of lithium in delayed phase of neuronal death against focal ischemia has not been explored. Therefore, the present study was designed to investigate the ef
  • PMID 26554621
  • Ultrasound of alternating frequencies and variable emotional impact evokes depressive syndrome in mice and rats.
  • Morozova A1, Zubkov E1, Strekalova T2, Kekelidze Z3, Storozeva Z3, Schroeter CA4, Bazhenova N5, Lesch KP6, Cline BH7, Chekhonin V8.
  • Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2016 Jul 4;68:52-63. doi: 10.1016/j.pnpbp.2016.03.003. Epub 2016 Mar 29.
  • Emotional stress is primarily triggered by the cognitive processing of negative input; it is regarded as a serious pathogenetic factor of depression that is challenging to model in animals. While available stress paradigms achieve considerable face and construct validity in modelling depressive diso
  • PMID 27036099
  • Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele.
  • Cao B1, Bauer IE2, Sharma AN2, Mwangi B2, Frazier T3, Lavagnino L2, Zunta-Soares GB2, Walss-Bass C2, Glahn DC4, Kapczinski F5, Nielsen DA6, Soares JC2.
  • Journal of affective disorders.J Affect Disord.2016 Jul 1;198:198-205. doi: 10.1016/j.jad.2016.03.044. Epub 2016 Mar 10.
  • BACKGROUND: Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. This study aimed to investigate the effect of BDNF polymorphism on hippocampus
  • PMID 27018938


  • Impact of Exercise and Vitamin B₁ Intake on Hippocampal Brain-Derived Neurotrophic Factor and Spatial Memory Performance in a Rat Model of Stress
  • DIEF Abeer E.,SAMY Diaa M.,DOWEDAR Fatma I.
  • Journal of nutritional science and vitaminology 61(1), 1-7, 2015-02
  • NAID 40020377912
  • Antidepressant-like effect of essential oil isolated from Toona ciliata Roem. var. yunnanensis
  • Duan Dongmei,Chen Liping,Yang Xiuyan [他]
  • Journal of natural medicines 69(2), 191-197, 2015
  • NAID 40020405839
  • 高強度インターバルトレーニングと血清脳由来神経栄養因子(BDNF)濃度との関連
  • 東 宏一郎,大澤 祐介,田畑 尚吾 [他],堀澤 栞里,勝川 史憲,石田 浩之,小熊 祐子,河合 俊英,小口 修司,太田 敦美,菊池 春人,村田 満,松本 秀男
  • 体力科学 64(2), 227-232, 2015
  • … To evaluate the association of serum BDNF concentration with high-intensity interval training, 12 healthy male volunteers, aged 28-48 years, completed 16-week high-intensity interval training (HIIT) using ergometer. … However, there was no change in serum BDNF concentration by HIIT. … On the other hand, there was a positive association of serum BDNF concentration at baseline with % increase in peak watt after the intervention (ρ=0.60, p<0.05). …
  • NAID 130005063349


この発表資料を分かりやすく解説した「60秒でわかるプレスリリース」もぜひご覧ください。 脳を構成する神経細胞には、小型(直径約50nm)のシナプス小胞※4 と大型(直径約80~120nm)の有芯小胞という2つの袋状の構造をした ...
→NGF/BDNF/GDNF (→PDGF) 胎生期の神経系の発生や生後のニューロンの維持は、神経栄養因子が担っている。 神経損傷後に起こる再生にも、神経栄養因子が影響を及ぼしている。



リンク元脳由来神経栄養因子」「brain-derived neurotrophic factor
拡張検索BDNF receptor」「BDNF受容体」「BDNFレセプター



brain-derived neurotrophic factorBDNF

brain-derived neurotrophic factor」



BDNF receptor」


TrkB receptor



BDNF receptor



BDNF receptor

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