関: creatine kinase BB

WordNet

develop into a distinctive entity; "our plans began to take shape" (同)take form, take shape, spring
assume a form or shape; "the water formed little beads"
the visual appearance of something or someone; "the delicate cast of his features" (同)shape, cast
a mold for setting concrete; "they built elaborate forms for pouring the foundation"
a particular mode in which something is manifested; "his resentment took the form of extreme hostility"
a perceptual structure; "the composition presents problems for students of musical form"; "a visual pattern must include not only objects but the spaces between them" (同)shape, pattern
(biology) a group of organisms within a species that differ in trivial ways from similar groups; "a new strain of microorganisms" (同)variant, strain, var.
the phonological or orthographic sound or appearance of a word that can be used to describe or identify something; "the inflected forms of a word can be represented by a stem and a list of inflections to be attached" (同)word form, signifier, descriptor
a printed document with spaces in which to write; "he filled out his tax form"
an ability to perform well; "he was at the top of his form"; "the team was off form last night"
an arrangement of the elements in a composition or discourse; "the essay was in the form of a dialogue"; "he first sketches the plot in outline form"
to compose or represent:"This wall forms the background of the stage setting"; "The branches made a roof"; "This makes a fine introduction" (同)constitute, make
create (as an entity); "social groups form everywhere"; "They formed a company" (同)organize, organise
the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B
an amino acid that does not occur in proteins but is found in the muscle tissue of vertebrates both in the free form and as phosphocreatine; supplies energy for muscle contraction (同)creatin
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

PrepTutorEJDIC

〈C〉〈U〉(色・材質に対して)『形』,形状,姿 / 〈C〉『人体』,体つき / 〈C〉〈U〉『外観』,格好,人影 / 〈C〉〈U〉(ものの現れる)『形態』,形式 / 〈C〉(生物などの)『種類』,品種 / 〈U〉(芸術作品の)表現形式 / 〈U〉(特にスポーツで)(競技者の)フォーム / 〈U〉(心身の)調子,元気 / 〈C〉(印刷された)書き込み用紙,ひな形 / 〈U〉《話》(ある集団などの)やり方,仕方,方式 / 〈C〉〈U〉しきたり,伝統的な儀式 / 〈C〉(英国の学校・米国のある学校で)学年,学級 / 〈U〉〈C〉(意味に対する)形態,形;語形 / 〈C〉(通例寄りかかりのない)長い木のいす / 〈素材〉‘に'形を与える,(…に)…‘を'形作る《+『名』+『into』+『名』》 / (素材から)…‘を'形作る《+『名』+『out of』+『名』》 / …‘を'組織する,構成する / 〈考えなど〉‘を'まとめる,思い付く;〈計画など〉‘を'立てる / 〈習慣など〉‘を'身に付ける;〈交際など〉‘を'結ぶ / 〈文章など〉‘を'組み立てる;〈複数形など〉‘を'作る / (ある順序に)配列する,整列させる / 〈物が〉形を成す / 生じる,現れる / (…に)なる《+『into』+『名』》
《時間・距離》『…の間』 / 《利益・貢献》『…のために』 / 《適応・用途》『…向きの(に);』…用の(に);…のための(に) / 《目的・意向》『…のために,』に / 《敬意・記念》『…のために;』…を記念して / 《獲得・追求》『…を得るために』,を求めて / 《行く先・方向》『…あてに;』…[方面]行きの,に向けて / 《交換・報償など》『…に対して』;…と引き換えに;…のお返しに / 《原因・理由》『…のために』,なので / 《代理・代表》『…の代わりに;』…を代表して / 《形容詞の後に用いて》『…にとって,』には / 《比較級の後に用いて》『…の結果として,』…のために / 《対比》『…としては,』のわりには / 《関連》『…について,』の点では / 《資格・属性》『…として』 / 《賛成・支持》…『に賛成して』,を支持して / 《傾向・好み》…『に対する』,には / 《模倣》《おもに米》《英文》…の名を取って(after) / 《割合》…に対して / 《『for』+『名』〈人〉+『to』 doの形で,〈人〉が不定詞to doの意味上の主語を表して》…が(…することは,…するために) / […というのは]…だから

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1. 心筋障害のバイオマーカーとしてのトロポニンおよびクレアチンキナーゼ troponins and creatine kinase as biomarkers of cardiac injury
2. 神経筋疾患の評価における筋酵素 muscle enzymes in the evaluation of neuromuscular diseases
3. トロポニンおよびクレアチンキナーゼ以外の心筋障害を示唆するバイオマーカー biomarkers suggesting cardiac injury other than troponins and creatine kinase
4. 急性心筋梗塞の診断基準 criteria for the diagnosis of acute myocardial infarction
5. ホスホグリセリン酸キナーゼ欠損症およびホスホグリセリン酸ムターゼ欠損症 phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency

English Journal

Anti-retinal antibodies in patients with macular telangiectasia type 2.

Zhu L1, Shen W, Zhu M, Coorey NJ, Nguyen AP, Barthelmes D, Gillies MC.Author information 1Save Sight Institute, The University of Sydney, Sydney, Australia. ling.zhu@sydney.edu.auAbstractPURPOSE: Macular telangiectasia type 2 (MacTel-2) is a retinal disease that can cause loss of central vision. To gain better understanding of the etiology and pathogenesis of MacTel-2, we investigated antigens that prompt the generation of retinal autoantibodies in the serum of patients with MacTel-2.
Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2013 Aug 21;54(8):5675-83. doi: 10.1167/iovs.13-12050.
PURPOSE: Macular telangiectasia type 2 (MacTel-2) is a retinal disease that can cause loss of central vision. To gain better understanding of the etiology and pathogenesis of MacTel-2, we investigated antigens that prompt the generation of retinal autoantibodies in the serum of patients with MacTel-
PMID 23882694

Mixtures of receiver operating characteristic curves.

Gönen M.Author information Memorial Sloan-Kettering Cancer Center, Department of Epidemiology and Biostatistics, 1275 York Ave, Box 44 New York, NY 10065, USA. gonenm@mskcc.orgAbstractRATIONALE AND OBJECTIVES: Receiver operating characteristic (ROC) curves are ubiquitous in the analysis of imaging metrics as markers of both diagnosis and prognosis. While empirical estimation of ROC curves remains the most popular method, there are several reasons to consider smooth estimates based on a parametric model.
Academic radiology.Acad Radiol.2013 Jul;20(7):831-7. doi: 10.1016/j.acra.2013.03.003. Epub 2013 May 3.
RATIONALE AND OBJECTIVES: Receiver operating characteristic (ROC) curves are ubiquitous in the analysis of imaging metrics as markers of both diagnosis and prognosis. While empirical estimation of ROC curves remains the most popular method, there are several reasons to consider smooth estimates base
PMID 23643788

Enhancement of brain-type creatine kinase activity ameliorates neuronal deficits in Huntington's disease.

Lin YS1, Cheng TH, Chang CP, Chen HM, Chern Y.Author information 1Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.AbstractHuntington's disease (HD) is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Brain-type creatine kinase (CKB) is an enzyme involved in energy homeostasis via the phosphocreatine-creatine kinase system. Although downregulation of CKB was previously reported in brains of HD mouse models and patients, such regulation and its functional consequence in HD are not fully understood. In the present study, we demonstrated that levels of CKB found in both the soma and processes were markedly reduced in primary neurons and brains of HD mice. We show for the first time that mutant HTT (mHTT) suppressed the activity of the promoter of the CKB gene, which contributes to the lowered CKB expression in HD. Exogenous expression of wild-type CKB, but not a dominant negative CKB mutant, rescued the ATP depletion, aggregate formation, impaired proteasome activity, and shortened neurites induced by mHTT. These findings suggest that negative regulation of CKB by mHTT is a key event in the pathogenesis of HD and contributes to the neuronal dysfunction associated with HD. In addition, besides dietary supplementation with the CKB substrate, strategies aimed at increasing CKB expression might lead to the development of therapeutic treatments for HD.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jun;1832(6):742-53. doi: 10.1016/j.bbadis.2013.02.006. Epub 2013 Feb 15.
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. Brain-type creatine kinase (CKB) is an enzyme involved in energy homeostasis via the phosphocreatine-creatine kinase system. Although downregulation of CKB was previous
PMID 23416527

Japanese Journal

Mitochondrial creatine kinase from human heart muscle: Purification and characterization of the crystallized isoenzyme.

BLUM Hubert E.,DEUS Bruno,GEROK Wolfgang
The Journal of Biochemistry 94(4), 1247-1257, 1983
… An isoenzyme of creatine kinase [ATP: creatine N-phosphotransferase, EC 2. … 2] was isolated in pure, crystalline form from mitochondria of human heart muscle. … The enzyme has a specific activity of 15±2 U/mg in the direction of creatine phosphate synthesis at optimum pH of 8.7 and of 45±5 U/mg in the direction of ATP synthesis at optimum pH of 6.7. …
NAID 130003542665