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- オーレオマイシン(抗生物質の商品名)
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/02 13:48:47」(JST)
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Chlortetracycline
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| Systematic (IUPAC) name |
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(4S,4aS,5aS,6S,12aS,Z)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydrotetracene-1,3,12(2H,4H,12aH)-trione
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| Clinical data |
| AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Routes of
administration |
Oral, IV, topical |
| Pharmacokinetic data |
| Bioavailability |
30% |
| Protein binding |
50 to 55% |
| Metabolism |
Hepatic (75%) |
| Biological half-life |
5.6 to 9 hours |
| Excretion |
Renal and biliary |
| Identifiers |
| CAS Number |
57-62-5 Y |
| ATC code |
A01AB21 (WHO) D06AA02 (WHO) J01AA03 (WHO) S01AA02 (WHO) QG51AA08 (WHO) QJ51AA03 (WHO) |
| ChemSpider |
10469370 Y |
| UNII |
WCK1KIQ23Q Y |
| KEGG |
D07689 Y |
| ChEMBL |
CHEMBL456066 N |
| Chemical data |
| Formula |
C22H23ClN2O8 |
| Molar mass |
478.88 g/mol |
SMILES
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CN(C)[C@@H]2C(\O)=C(\C(N)=O)C(=O)[C@@]3(O)C(/O)=C4/C(=O)c1c(O)ccc(Cl)c1[C@@](C)(O)[C@H]4C[C@@H]23
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InChI
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InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1 Y
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Key:CYDMQBQPVICBEU-XRNKAMNCSA-N Y
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| NY (what is this?) (verify) |
Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 by Benjamin Minge Duggar working at Lederle Laboratories under the supervision of Yellapragada Subbarow. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.[1] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.
In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.[2]
References
- ^ Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
- ^ Merck Veterinary Manual.
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Stomatological preparations (A01)
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| Caries prophylaxis |
- Dectaflur
- Olaflur
- Sodium fluoride
- Sodium monofluorophosphate
- Stannous fluoride
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| Infection and antiseptics |
- Amphotericin B
- Benzoxonium chloride
- Chlorhexidine
- Chlortetracycline
- Clotrimazole
- Cetylpyridinium chloride
- Domiphen bromide
- Doxycycline
- Eugenol
- Hexetidine
- Hydrogen peroxide
- Mepartricin
- Metronidazole
- Miconazole
- Minocycline
- Natamycin
- Neomycin
- Oxyquinoline
- Polynoxylin
- Sodium perborate
- Tetracycline
- Tibezonium iodide
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Corticosteroids
(Glucocorticoids) |
- Dexamethasone
- Hydrocortisone
- Triamcinolone
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| Other |
- Amlexanox
- Acetylsalicylic acid
- Becaplermin
- Benzydamine
- Epinephrine/Adrenalone
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Antibiotics and chemotherapeutics for dermatological use (D06)
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| Antibiotics |
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Tetracycline and derivatives
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- Demeclocycline
- Chlortetracycline
- Oxytetracycline
- Tetracycline
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Others
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- Amphenicol: Chloramphenicol
- Aminoglycosides: Neomycin
- Gentamicin
- Amikacin
- Streptogramin: Virginiamycin
- other: Fusidic acid
- Bacitracin
- Tyrothricin
- Mupirocin
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| Chemotherapeutics |
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Sulfonamides
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- Silver sulfadiazine
- Sulfathiazole
- Mafenide
- Sulfamethizole
- Sulfanilamide
- Sulfamerazine
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Antivirals
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- Aciclovir
- Penciclovir
- Idoxuridine
- Edoxudine
- Imiquimod
- Resiquimod
- Podophyllotoxin
- Docosanol
- Tromantadine
- Inosine
- Lysozyme
- Ibacitabine
- Lysine
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Other
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- Ingenol mebutate
- Metronidazole
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Antibacterials: protein synthesis inhibitors (J01A, J01B, J01F, J01G, QJ01XQ)
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| 30S |
Aminoglycosides
(initiation inhibitors) |
| -mycin (Streptomyces) |
- Streptomycin#
- Dihydrostreptomycin
- Neomycin#
- Framycetin
- Paromomycin
- Ribostamycin
- Kanamycin#
- Amikacin
- Arbekacin
- Bekanamycin
- Dibekacin
- Tobramycin
- Spectinomycin#
- Hygromycin B
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| -micin (Micromonospora) |
- Gentamicin#
- Netilmicin
- Sisomicin
- Plazomicin†
- Isepamicin
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Tetracycline antibiotics
(tRNA binding) |
| Tetracyclines |
- Doxycycline#
- Chlortetracycline
- Clomocycline
- Demeclocycline
- Lymecycline
- Meclocycline
- Metacycline
- Minocycline
- Oxytetracycline
- Penimepicycline
- Rolitetracycline
- Tetracycline
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| Glycylcyclines |
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| 50S |
Oxazolidinone
(initiation inhibitors) |
- Eperezolid
- Linezolid
- Posizolid
- Radezolid
- Ranbezolid
- Sutezolid
- Tedizolid
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| Peptidyl transferase |
| Amphenicols |
- Chloramphenicol#
- Azidamfenicol
- Thiamphenicol
- Florfenicol
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| Pleuromutilins |
- Retapamulin
- Tiamulin
- Valnemulin
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| MLS (transpeptidation/translocation) |
| Macrolides |
- Azithromycin#
- Clarithromycin
- Dirithromycin
- Erythromycin#
- Flurithromycin
- Josamycin
- Midecamycin
- Miocamycin
- Oleandomycin
- Rokitamycin
- Roxithromycin
- Spiramycin
- Troleandomycin
- Tylosin
- Ketolides
- Telithromycin
- Cethromycin
- Solithromycin†
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| Lincosamides |
- Clindamycin#
- Lincomycin
- Pirlimycin
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| Streptogramins |
- Pristinamycin
- Quinupristin/dalfopristin
- Virginiamycin
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| EF-G |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- Impact of chlortetracycline on sequencing batch reactor performance for swine manure treatment.
- Stone JJ, Oswald AS, Lupo CD, Clay SA, Mott HV.SourceDepartment of Civil and Environmental Engineering, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA.
- Bioresource technology.Bioresour Technol.2011 Sep;102(17):7807-14. Epub 2011 Jun 16.
- Treatment of aged (500day, 4°C stored) chlortetracycline (CTC; 0, 20, 40, 80mg/L CTC)-amended swine manure using two cycle, 22day stage anaerobic sequencing batch reactors (SBR) was assessed. Eighty milligrams per liter CTC treatment inhibited SBR treatment efficiencies, although total gas producti
- PMID 21724384
- Characterization of organic matter degradation during composting of manure-straw mixtures spiked with tetracyclines.
- Hu Z, Liu Y, Chen G, Gui X, Chen T, Zhan X.SourceSchool of Civil Engineering, Hefei University of Technology, Hefei, China. huzhenhu@ustc.edu
- Bioresource technology.Bioresour Technol.2011 Aug;102(15):7329-34. Epub 2011 May 7.
- The objective of this study was to investigate humification and mineralization of manure-straw mixtures contaminated by tetracyclines during composting. Hen manure, pig manure and rice straw were used as the raw materials. The manure-straw mixtures were spiked with tetracycline, chlortetracycline, a
- PMID 21620695
Japanese Journal
- オーレオマイシン長期投与の,雌マウスの発育,腸内菌叢,乳癌発生におよぼす影響について
- 長澤 弘,宮本 盛吉,伊藤 喜久治,光岡 知足
- 日本畜産学会報 52(8), 567-571, 1981
- 実験動物の管理および実験の場において,とくに長期にわたる実験では,肺炎や下痢症などに対する感染予防はきわめて重要な要件となる.この目的のための抗生物質投与の影響を検討する一環として,長期にわたってオーレオマイシンを投与された雌マウスの,発育,腸内菌叢,乳腺の発育,臓器重量などを検討した,使用したマウスは,乳癌高発系SHNである.20日齢の離乳時に,同腹雌を2群にわけ,実験群には,その有効性が長年に …
- NAID 130000736738
- シン ダヤラム,堀 浩二
- 帯広畜産大学学術研究報告. 第I部 11(3), 475-481, 1979-11-20
- … bacitracinとdihydrostreptomycinの混合とaureomycinとterramycinの混合はこの害虫に対して共力作用を示すらしい。 …
- NAID 110006454250
Related Links
- Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be discovered. It was discovered in 1945 by Dr Benjamin Duggar in a soil sample from Sanborn Field at the University of ...
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