WordNet

cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue" (同)alter, modify
become different in some particular way, without permanently losing ones or its former characteristics or essence; "her mood changes in accordance with the weather"; "The supermarkets selection of vegetables varies according to the season" (同)alter, vary
exchange or replace with another, usually of the same kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert centimeters into inches"; "convert holdings into shares" (同)exchange, commute, convert
a relational difference between states; especially between states before and after some event; "he attributed the change to their marriage"
change clothes; put on different clothes; "Change before you go to the opera"
coins of small denomination regarded collectively; "he had a pocketful of change"
money received in return for its equivalent in a larger denomination or a different currency; "he got change for a twenty and used it to pay the taxi driver"
remove or replace the coverings of; "Father had to learn how to change the baby"; "After each guest we changed the bed linens"
the balance of money received when the amount you tender is greater than the amount due; "I paid with a twenty and pocketed the change"
the result of alteration or modification; "there were marked changes in the lining of the lungs"; "there had been no change in the mountains"
undergo a change; become different in essence; losing ones or its original nature; "She changed completely as she grew older"; "The weather changed last night"
a different or fresh set of clothes; "she brought a change in her overnight bag"
a thing that is different; "he inspected several changes before selecting one"
the action of changing something; "the change of government had no impact on the economy"; "his change on abortion cost him the election"
an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago" (同)alteration, modification
made or become different in some respect; "hes an altered (or changed) man since his election to Congress"
changed in constitution or structure or composition by metamorphism; "metamorphic rocks"
made or become different in nature or form; "changed attitudes"; "changed styles of dress"; "a greatly changed country after the war"
marked by continuous change or effective action (同)ever-changing

PrepTutorEJDIC

(…に)…'を'『変える』,改める《+『名』+『into』+『名』》 / …'を'『取り替える』,交換する / 〈小切手・為替〉'を'現金にする,〈金〉'を'両替えする;(…に)…'を'両替する《+『名』+『into』+『名』》 / (…に)『変わる』,変化する《+『to』(『into』)+『名』》 / (他の衣服に)着替える《+『into』+『名』》 / (…に)乗り換える《+『to』+『名』》 / 〈C〉(…の)『変化』,移り変わり,変遷《+『of』+『名』》 / 〈C〉(…の)『取り替え』,交換;乗り換え《+『of』+『名』》 / 〈U〉釣り銭,小銭

UpToDate Contents

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1. アルツハイマー病の疫学、病理、および病因 epidemiology pathology and pathogenesis of alzheimer disease
2. アルツハイマー病の遺伝学 genetics of alzheimer disease
3. アルツハイマー病の臨床的特徴および診断 clinical features and diagnosis of alzheimer disease
4. 脳血管性認知症の病因、臨床症状、および診断 etiology clinical manifestations and diagnosis of vascular dementia
5. 認知症治療におけるコリンエステラーゼ阻害剤 cholinesterase inhibitors in the treatment of dementia

English Journal

Review: Astrocytes in Alzheimer's disease and other age-associated dementias; a supporting player with a central role.

Garwood CJ1, Ratcliffe LE1, Simpson JE1, Heath PR1, Ince PG1, Wharton SB1.
Neuropathology and applied neurobiology.Neuropathol Appl Neurobiol.2016 Jul 21. doi: 10.1111/nan.12338. [Epub ahead of print]
Astrocytes have essential roles in the central nervous system and are also implicated in the pathogenesis of neurodegenerative disease. Forming non-overlapping domains, astrocytes are highly complex cells. Immunohistochemistry to a variety of proteins can be used to study astrocytes in tissue, label
PMID 27442752

Intracerebroventricular administration of okadaic acid induces hippocampal glucose uptake dysfunction and tau phosphorylation.

Broetto N1, Hansen F2, Brolese G1, Batassini C2, Lirio F2, Galland F2, Dos Santos JP2, Dutra MF3, Gonçalves CA4.
Brain research bulletin.Brain Res Bull.2016 Jun;124:136-43. doi: 10.1016/j.brainresbull.2016.04.014. Epub 2016 Apr 21.
Intraneuronal aggregates of neurofibrillary tangles (NFTs), together with beta-amyloid plaques and astrogliosis, are histological markers of Alzheimer's disease (AD). The underlying mechanism of sporadic AD remains poorly understood, but abnormal hyperphosphorylation of tau protein is suggested to h
PMID 27108544

Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum.

Serrano-Pozo A1, Qian J1, Muzikansky A1, Monsell SE1, Montine TJ1, Frosch MP1, Betensky RA1, Hyman BT2.
Journal of neuropathology and experimental neurology.J Neuropathol Exp Neurol.2016 Jun;75(6):516-26. doi: 10.1093/jnen/nlw026. Epub 2016 Apr 22.
The 2012 neuropathological criteria for the diagnosis of Alzheimer disease (AD) summarize the extent of AD neuropathological change with an ABC score, which is a composite of the Thal stage of amyloid deposition (A), the Braak stage of neurofibrillary tangles (NFTs) (B), and the CERAD neuritic plaqu
PMID 27105663

Japanese Journal

アルツハイマー病において極めて緩徐な進行を示す一群について : 物忘れ外来における検討

高次脳機能研究 : 日本高次脳機能障害学会誌 = Higher brain function research 32(4), 590-600, 2012-12-31
NAID 10031154800

ものわすれ外来でフォロー中に軽度認知障害から認知症へ移行した嗜銀顆粒性認知症の1剖検例

臨床神経学 52(9), 660-665, 2012
NAID 130004505290

Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology : An autopsy case showing typical clinical features of Creutzfeldt-Jakob disease

Neuropathology : official journal the Japanese Society of Neuropathology 29(4), 454-459, 2009-08-01
NAID 10028191795