A kinase

プロテインキナーゼA

WordNet

1. the 1st letter of the Roman alphabet (同)a
2. the blood group whose red cells carry the A antigen (同)type_A, group A
3. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
4. the basic unit of money in Papua New Guinea

PrepTutorEJDIC

1. answer / ampere
2. arsenicの化学記号

UpToDate Contents

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• 1. ピルビン酸キナーゼ欠損症 pyruvate kinase deficiency
• 2. 未分化リンパ腫キナーゼ（ALK）融合癌遺伝子陽性非小細胞肺癌 anaplastic lymphoma kinase alk fusion oncogene positive non small cell lung cancer
• 3. 進行消化管間質腫瘍に対するチロシンキナーゼ阻害剤療法 tyrosine kinase inhibitor therapy for advanced gastrointestinal stromal tumors
• 4. 横紋筋融解症の原因 causes of rhabdomyolysis
• 5. 神経有棘赤血球症 neuroacanthocytosis

English Journal

• Measurement of Cdk1/Cyclin B Kinase Activity by Specific Antibodies and Western Blotting.

• Lewis CW1, Taylor RG, Golsteyn RM.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1342:337-48. doi: 10.1007/978-1-4939-2957-3_21.
• Quantitative measurement of enzyme activity is a valuable approach to study how cells function. We present a method to measure the activity of the enzyme Cdk1/cyclin B. This enzyme is required by all eukaryotic cells to enter mitosis. Therefore, a biochemical assay to measure Cdk1/cyclin B activity
• PMID 26254935

• Combining the Optimized Yeast Cytosine Deaminase Protein Fragment Complementation Assay and an In Vitro Cdk1 Targeting Assay to Study the Regulation of the γ-Tubulin Complex.

• Ear PH1, Kowarzyk J, Booth MJ, Abd-Rabbo D, Shulist K, Hall C, Vogel J, Michnick SW.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1342:237-57. doi: 10.1007/978-1-4939-2957-3_14.
• Cdk1 is the essential cyclin-dependent kinase in the budding yeast Saccharomyces cerevisiae. Cdk1 orchestrates cell cycle control by phosphorylating target proteins with extraordinary temporal and spatial specificity by complexing with one of the nine cyclin regulatory subunits. The identification o
• PMID 26254928

• Measuring Activity and Specificity of Protein Phosphatases.

• Powers BL1, Melesse M, Eissler CL, Charbonneau H, Hall MC.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1342:221-35. doi: 10.1007/978-1-4939-2957-3_13.
• Reversible protein phosphorylation plays essential roles in coordinating cell division and many other biological processes. Cell cycle regulation by opposing kinase and protein phosphatase activities is often complex and major challenges exist in identifying the direct substrates of these enzymes an
• PMID 26254927

Japanese Journal

• Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites.

• Fukumitsu Kansai,Fujishima Kazuto,Yoshimura Azumi,Wu You Kure,Heuser John,Kengaku Mineko
• The Journal of neuroscience : the official journal of the Society for Neuroscience 35(14), 5707-5723, 2015-04-08
• … Additionally, we find that the growth of atrophic dendrites lacking mitochondria can be rescued by activating ATP-phosphocreatine exchange mediated by creatine kinase (CK). …
• NAID 120005593705

• <i>In silico</i> spleen tyrosine kinase inhibitor screening by chooseLD

• Hideaki Umeyama,Mitsuo Iwadate,Y-H. Taguchi
• 研究報告バイオ情報学（BIO） 2015-BIO-41(9), 1-6, 2015-03-13
• … Background: Spleen tyrosine kinase (SYK) is a protein related to various diseases. … Furthermore, many compounds in the DrugBank database were newly identified as having high affinity to ATP binding sites in the kinase domain with a similar affinity to previously reported inhibitors. …
• NAID 170000121229

• <i>In silico</i> spleen tyrosine kinase inhibitor screening by chooseLD

• Hideaki Umeyama,Mitsuo Iwadate,Y-H. Taguchi
• 情報処理学会研究報告. BIO, バイオ情報学 2015-BIO-41(9), 1-6, 2015-03-13
• … Background: Spleen tyrosine kinase (SYK) is a protein related to various diseases. … Furthermore, many compounds in the DrugBank database were newly identified as having high affinity to ATP binding sites in the kinase domain with a similar affinity to previously reported inhibitors. …
• NAID 110009884014

Related Links

• Aキナーゼとは - コトバンク

栄養・生化学辞典 - Aキナーゼの用語解説 - プロテインキナーゼAともいう．cAMPによって活性が調節されるタンパク質キナーゼ．cAMPを介する信号伝達系で重要な機能を果たす．エピネフリン，グルカゴン，甲状腺刺激ホルモンその他多く ...

• Protein Kinases, Kinomes and Evolution, at Kinase.Com

A resource on protein kinases, a key class of regulatory proteins. Includes genomic and evolutionary analyses, classification, disease associations and an extensive database of protein kinase genes.

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★リンクテーブル★

リンク元	「プロテインキナーゼA」
拡張検索	「A-kinase」「DNA kinase」「A kinase anchor protein」
関連記事	「A」「kinase」「Ad」

「プロテインキナーゼA」

　　[★]

英

protein kinase A PKA

同

Aキナーゼ A kinase、サイクリックAMP依存性プロテインキナーゼ cyclic AMP-dependent protein kinase

関

プロテインキナーゼ protein kinase

「A-kinase」

　　[★]

Aキナーゼ、プロテインキナーゼA、サイクリックAMP依存性タンパク質リン酸化酵素

関

cAMP-dependent protein kinase、PKA、protein kinase A

「DNA kinase」

　　[★]

DNAキナーゼ

関

polynucleotide 5'-hydroxyl-kinase、polynucleotide kinase

「A kinase anchor protein」

　　[★]

Aキナーゼアンカータンパク質

関

AKAP

「A」

　　[★]

• アデニン adenine
• アデノシン adenosine
• アラニン alanine

　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「Ad」

　　[★]

• アデノウイルス

関

adenoviral、adenovirus