WordNet
- 100 at equal 1 kip in Laos
- the 9th letter of the Roman alphabet (同)i
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
PrepTutorEJDIC
- 《場所・位置のある一点》『…で』,『…に』 / 《時間・年齢・目盛りなどの一点》『…に』,『…で』 / 『…の最中で』,に出席して / 『…の状態に』(『で』) / 『…を目指して』,に向かって / 《移動の経路》…を通って,…から / 《動作・感情などの原因・理由・動機》『…によって』,…を見て(聞いて,知って) / 《運動・動作の方法・様態》…で,…のやり方で / 《数量・割合・率》…で,…に / 《能力・性質などの存在場所》…が,…の点で
- 『私は』私が
- iodineの化学記号
- answer / ampere
UpToDate Contents
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- 1. 分娩時の妊婦の気道管理 airway management of pregnant women at delivery
- 2. 心臓におけるアンギオテンシンⅡの作用 actions of angiotensin ii on the heart
- 3. 成人心疾患の小児期の予防：健康な生活様式の向上およびリスクのある小児の識別 pediatric prevention of adult cardiovascular disease promoting a healthy lifestyle and identifying at risk children
- 4. 毛細血管拡張性運動失調症 ataxia telangiectasia
- 5. 第2度房室ブロック：モビッツII型 second degree atrioventricular block mobitz type ii
English Journal
- Fatty Acid synthase inhibitor c75 ameliorates experimental colitis.
- Matsuo S1, Yang WL2, Aziz M2, Kameoka S3, Wang P2.Author information 1Department of Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, and The Feinstein Institute for Medical Research, Manhasset, New York, United States of America Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.2Department of Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, and The Feinstein Institute for Medical Research, Manhasset, New York, United States of America.3Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.AbstractAbnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD). C75 is a synthetic α-methylene-γ-butyrolactone compound that inhibits FASN activity. We hypothesized that C75 treatment could effectively reduce the severity of experimental colitis. Male C57BL/6 mice were fed 4% dextran sodium sulfate (DSS) for 7 d. C75 (5 mg/kg body weight) or dimethyl sulfoxide (DMSO) (vehicle) was administered intraperitoneally from d 2 to 6. Clinical parameters were monitored daily. Mice were euthanized on d 8 for histological evaluation and measurements of colon length, chemokine, cytokine and inflammatory mediator expression. C75 significantly reduced body weight loss from 23% to 15% on d 8, compared with the vehicle group. The fecal bleeding, diarrhea and colon histological damage scores in the C75-treated group were significantly lower than scores in the vehicle animals. Colon shortening was significantly improved after C75 treatment. C75 protected colon tissues from DSS-induced apoptosis by inhibiting caspase-3 activity. Macrophage inflammatory protein 2, keratinocyte-derived chemokine, myeloperoxidase activity and proinflammatory cytokines (tumor necrosis factor-α, interleukin [IL]-1β and IL-6) in the colon were significantly downregulated in the C75-treated group, compared with the vehicle group. Treatment with C75 in colitis mice inhibited the elevation of FASN, cyclooxygenase-2 and inducible nitric oxide synthase expression as well as IκB degradation in colon tissues. C75 administration alleviates the severity of colon damage and inhibits the activation of inflammatory pathways in DSS-induced colitis. Thus, inhibition of FASN may represent an attractive therapeutic potential for treating IBD.
- Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):1-9. doi: 10.2119/molmed.2013.00113.
- Abnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD). C75 is a synthetic α-methylene-γ-butyrolactone compound that inhibits FASN activ
- PMID 24306512
- Depressive symptoms are not associated with forearm bone accrual during adolescence.
- Lourenço S1, Lucas R, da Silva DF, Ramos E, Barros H.Author information 1Institute of Public Health of the University of Porto, Rua das Taipas, 135-139, 4050-600, Porto, Portugal, slourenco@med.up.pt.AbstractAlthough depression has been associated to worst bone physical properties in adulthood, this study showed that depressive symptoms were not significantly associated to bone mineral density measured at the forearm during adolescence.
- Archives of osteoporosis.Arch Osteoporos.2014 Dec;9(1):173. doi: 10.1007/s11657-014-0173-4. Epub 2014 Mar 12.
- Although depression has been associated to worst bone physical properties in adulthood, this study showed that depressive symptoms were not significantly associated to bone mineral density measured at the forearm during adolescence.PURPOSE: Depressive conditions have been related to the reduction of
- PMID 24619250
- Acrodermatitis continua of Hallopeau (ACH): two cases successfully treated with adalimumab.
- Di Costanzo L1, Napolitano M, Patruno C, Cantelli M, Balato N.Author information 1Department of Clinical Medicine and Surgery, University of Naples Federico II , Naples , Italy.AbstractAcrodermatitis continua of Hallopeau (ACH), also known as dermatitis repens or acrodermatitis perstans, is a rare acropustular eruption, characterized by sterile pustules, paronychia and atrophic skin changes, onychodystrophy and osteolysis of the distal phalanges of the fingers and toes. While some consider ACH a distinct entity, many believe it to be a variant of pustular psoriasis, especially as cases of ACH progressing to generalized pustular psoriasis. The treatment options used are various; however, its typical cyclic recurrences, which induce important physical and psychological morbidity, may render this pathology difficult to treat. Hence, it was considered important to review the evolution of treatment options available thus far including use of biologics. Hereby, we report two patients with ACH who were successfully treated with adalimumab. By analogy to the efficacy of TNF-α antagonists in the treatment of generalized pustular psoriasis, the two patients we report illustrate the long-term efficacy and safety of adalimumab in the treatment of Hallopeau's acrodermatitis refractory to therapies.
- The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):489-94. doi: 10.3109/09546634.2013.848259. Epub 2013 Nov 12.
- Acrodermatitis continua of Hallopeau (ACH), also known as dermatitis repens or acrodermatitis perstans, is a rare acropustular eruption, characterized by sterile pustules, paronychia and atrophic skin changes, onychodystrophy and osteolysis of the distal phalanges of the fingers and toes. While some
- PMID 24215490
Japanese Journal
- Precipitation Process of Calcium Phosphate from Calcium Carbonate Suspension
- da Silva Nayane Macedo Portela,Espitalier Fabienne,Nzihou Ange
- KONA Powder and Particle Journal advpub(0), 2016
- … The experiments were performed in a batch reactor at 25 °C. … Samples of the synthesis were collected at different intervals and analysed by laser granulometry and by environmental scanning electron microscopy.For the synthesis conducted at 260 rpm, synthesis monitoring was made using a contact probe in solution coupled to a Raman spectrometer in order to follow the formation of solid phase. …
- NAID 130005068880
- Selective crystallization of metastable phase of acetaminophen by ultrasonic irradiation
- Mori Yoichiro,Maruyama Mihoko,Takahashi Yoshinori,Ikeda Kenji,Fukukita Suguru,Yoshikawa Hiroshi,Okada Shino,Adachi Hiroaki,Sugiyama Shigeru,Takano Kazufumi,Murakami Satoshi,Matsumura Hiroyoshi,Inoue Tsuyoshi,Yoshimura Masashi,Mori Yusuke
- Appl. Phys. Express 8(6), 065501, 2015-05-20
- … A new method for selective crystallization of the metastable phase (form II) of acetaminophen is described. … To obtain form II, we prepared a highly supersaturated solution (σ<inf>I</inf>= 3.7) and then applied ultrasonic irradiation at different frequencies. … When ultrasonic irradiation at 28 kHz was applied, form II preferentially crystallized. …
- NAID 150000110732
- 中国語の"会"に関する一考察 : 「Ⅰ.能力」「Ⅱ.長じる」ではない第Ⅲ類の"会"を中心に
- 王 其莉
- 日中言語対照研究論集 = Comparative studies in Japanese and Chinese (17), 135-153, 2015-05
- NAID 40020481972
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Related Pictures
★リンクテーブル★
| リンク元 | 「アンジオテンシンII」「angiotensin II」 |
| 拡張検索 | 「AT-III」「ATIII」 |
| 関連記事 | 「AT」「II」「I」「A」 |
「アンジオテンシンII」
標的組織
受容体 (PPC.348,SP.612)
- AT1受容体：血管、副腎皮質、脳室周囲器官 (SP.612)
- 血管収縮、アルドステロン分泌(副腎皮質)、交感神経刺激作用、心肥大・血管肥厚
- AT2受容体：脳その他の臓器に存在し、NOの産生を介して血管を弛緩させるなどAT1受容体の機能に拮抗 (SP.612)
- NO遊離(血管拡張)、アポトーシス
作用
- アルドステロン分泌
- Na+再吸収を促進→血漿量↑→血圧↑
「angiotensin II」
「AT-III」
[★] アンチトロンビンIII antithrombin III
「ATIII」
「AT」
- 無酸素性作業閾値 anaerobic threshold
- 毛細血管拡張性運動失調症 ataxia telangiectasia
- アンチトロンビン antithrombin
- 加速時間 acceleration time
「II」
「I」
「A」