WordNet
- (genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism (同)genetic mutation, chromosomal_mutation
- a change or alteration in form or qualities
- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
PrepTutorEJDIC
- 変化,俸転 / (生物の)突然変異;その変種
- 遺伝子
- answer / ampere
- antipersonnel / (またA.P.)Associated Press
UpToDate Contents
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- 1. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases
- 2. アルツハイマー病の遺伝学 genetics of alzheimer disease
- 3. 認知症の危険因子 risk factors for dementia
- 4. 上皮成長因子受容体変異を有する進行非小細胞肺癌に対する全身療法 systemic therapy for advanced non small cell lung cancer with an activating mutation in the epidermal growth factor receptor
- 5. ドライバー変異が認められない進行非小細胞肺癌に対する初期全身化学療法 initial systemic chemotherapy for advanced non small cell lung cancer without a driver mutation
English Journal
- Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies.
- Geiger JT1, Ding J2, Crain B3, Pletnikova O3, Letson C2, Dawson TM4, Rosenthal LS5, Pantelyat A5, Gibbs JR2, Albert MS5, Hernandez DG2, Hillis AE5, Stone DJ6, Singleton AB2; North American Brain Expression Consortium, Hardy JA7, Troncoso JC8, Scholz SW9.
- Neurobiology of disease.Neurobiol Dis.2016 Oct;94:55-62. doi: 10.1016/j.nbd.2016.06.004. Epub 2016 Jun 14.
- Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease. Although an increasing number of genetic factors have been connected to this debilitating condition, the proportion of cases that can be attributed to distinct genetic defects is unknown.
- PMID 27312774
- Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer's disease.
- Caberlotto L1, Marchetti L1, Lauria M1, Scotti M1,2, Parolo S1.
- Scientific reports.Sci Rep.2016 Sep 2;6:32583. doi: 10.1038/srep32583.
- Among the genetic factors known to increase the risk of late onset Alzheimer's diseases (AD), the presence of the apolipoproteine e4 (APOE4) allele has been recognized as the one with the strongest effect. However, despite decades of research, the pathogenic role of APOE4 in Alzheimer's disease has
- PMID 27585646
- Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies.
- Fröhlich C1, Zschiebsch K1,2, Gröger V1,3, Paarmann K4,1,5, Steffen J4,1,5, Thurm C1, Schropp EM1, Brüning T4,1, Gellerich F6, Radloff M7, Schwabe R7, Lachmann I8, Krohn M4,1, Ibrahim S5, Pahnke J9,10,11,12.
- Molecular neurobiology.Mol Neurobiol.2016 Sep;53(7):4728-44. doi: 10.1007/s12035-015-9399-4. Epub 2015 Aug 29.
- Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP
- PMID 26319560
Japanese Journal
- 症例報告 多彩な精神症状を呈し,遺伝子診断によりAPP遺伝子変異を認めた若年院Alzheimer病の1例
- 石丸 喬士,越智 紳一郎,松本 光央 [他]
- 精神神経学雑誌 115(10), 1042-1050, 2013
- NAID 40019838319
- A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis
- DI FEDE G
- Science 323, 1473-1477, 2009
- NAID 80020179369
- アルツハイマー病の分子医学 (特集 老化の分子医学--老化・寿命コントロールの実現に向けて)
- 浦上 克哉,涌谷 陽介,中島 健二
- モレキュラ-メディシン 39(5), 556-561, 2002-05
- NAID 40004990660
Related Pictures
★リンクテーブル★
| 関連記事 | 「AP」「APP」「A」「APP gene」 |
「AP」
- 狭心症 angina pectoris,
- アルカリホスファターゼ alkaline phosphatase
- 活動電位 action potential
- アクチベーター蛋白質 activator protein
- アミノプリン aminopurine
- 順行性腎盂造影 antegrade pyelography
「APP」
- 急性期タンパク質 acute phase protein=急性相反応物質 acute phase reactant
- アミロイド前駆体タンパク質 アミロイド前駆体蛋白質 amyloid precursor protein
- 虫垂炎 appendicitis
「A」