アデノシン一リン酸デアミナーゼ、アデニル酸デアミナーゼ、アデニル酸脱アミノ酵素、AMPデアミナーゼ

WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

answer / ampere

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/14 23:54:46」(JST)

wiki en

[Wiki en表示]

AMP deaminase 1 is an enzyme that in humans is encoded by the AMPD1 gene.^[1]^[2]

Adenosine monophosphate deaminase is an enzyme that converts adenosine monophosphate (AMP) to inosine monophosphate (IMP), freeing an ammonia molecule in the process.

Function

Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythrocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human.^[2]

Function

It is a part of the metabolic process that converts sugar, fat, and protein into cellular energy.^{[citation needed]}

In order to use energy, a cell converts one of the above fuels into adenosine triphosphate (ATP) via the mitochondria. Cellular processes, especially muscles, then convert the ATP into adenosine diphosphate (ADP), freeing the energy to do work.^{[citation needed]}

A new research report shows that the widely-prescribed diabetes medication metformin works on AMP kinase by directly inhibiting AMP deaminase, thereby increasing cellular AMP.^[3]

Pathology

A deficiency is associated with myoadenylate deaminase deficiency.

adenosine monophosphate (AMP)
inosine monophosphate (IMP)

References

^ Mahnke-Zizelman DK, Sabina RL (October 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons". J. Biol. Chem. 267 (29): 20866–77. PMID 1400401.
^ ^a ^b EntrezGene 270
^ Ouyang J, Parakhia RA, Ochs RS (January 2011). "Metformin activates AMP kinase through inhibition of AMP deaminase". J. Biol. Chem. 286 (1): 1–11. doi:10.1074/jbc.M110.121806. PMC 3012963. PMID 21059655. ^{[unreliable medical source?]}

External links

AMP Deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)

This hydrolase article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. アデノシンデアミナーゼ欠損症：治療 adenosine deaminase deficiency treatment
2. アデノシンデアミナーゼ欠損症：病因、臨床症状、および診断 adenosine deaminase deficiency pathogenesis clinical manifestations and diagnosis
3. 代謝性ミオパチーの原因 causes of metabolic myopathies
4. 心筋における興奮収縮連関 excitation contraction coupling in myocardium
5. 脳卒中の二次予防のための抗血小板療法 antiplatelet therapy for secondary prevention of stroke

English Journal

Activities of ectonucleotidases and adenosine deaminase in platelets of dogs experimentally infected with Rangelia vitalii.

Paim CB, Da Silva AS, Paim FC, França RT, Costa MM, Souza VC, Pimentel VC, Jaques JA, Mazzanti CM, Leal DB, Monteiro SG, Schetinger MR, Lopes ST.SourceDepartment of Small Animals, Universidade Federal de Santa Maria, Brazil.
Experimental parasitology.Exp Parasitol.2012 Mar 27. [Epub ahead of print]
Rangeliosis is a disease which affects dogs in Brazil, caused by a piroplasm known as Rangelia vitalii. This disease causes a lot of clinico-pathological features, including the coagulation disorders associated with bleeding. The cause of these changes has not yet been determined. Considering the as
PMID 22475775

Overexpression of AMP-metabolizing enzymes controls adenine nucleotide levels and AMPK activation in HEK293T cells.

Plaideau C, Liu J, Hartleib-Geschwindner J, Bastin-Coyette L, Bontemps F, Oscarsson J, Hue L, Rider MH.Source*Université Catholique de Louvain and de Duve Institute, Brussels, Belgium; and.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2012 Mar 13. [Epub ahead of print]
We investigated whether overexpression of AMP-metabolizing enzymes in intact cells would modulate oligomycin-induced AMPK activation. Human embryonic kidney (HEK) 293T cells were transiently transfected with increasing amounts of plasmid vectors to obtain a graded increase in overexpression of AMP-d
PMID 22415305

Japanese Journal

Uptake of AMP, ADP, and ATP in Escherichia coli W

WATANABE Kimiko,TOMIOKA Satsuki,TANIMURA Kiyoko,OKU Hisae,ISOI Koichiro
Bioscience, biotechnology, and biochemistry 75(1), 7-12, 2011-01-23
… The uptake activity ratio for AMP, ADP, and ATP in mutant (T-1) cells of Escherichia coli W, deficient in de novo purine biosynthesis at a point between IMP and 5-aminoimidazole-4-carboxiamide-1-β-D-ribofuranoside (AICAR), was 1:0.43:0.19. … AMP > … About 2-fold more radioactive purine bases than purine nucleosides were detected in the cytoplasm after 5 min in an experiment with [8-14C]AMP and T-1 cells. …
NAID 10027896383

β_3-adrenoceptor-mediated increased circulating transaminase levels in mice treated with its agonist BRL 37344

KASAHARA Hiroko,MUTO Shin-ichi,MOTOKAWA Yoshiyuki,ARISAKA Nobuhiko,KOBAYASHI Sayaka,SOUMA Shinji,KURODA Junji
Journal of toxicological sciences 35(5), 779-784, 2010-10-01
… The transaminase changes were not accompanied by increases in circulating levels of other hepatocellular enzymes, including guanine deaminase (GUA), glutamate dehydrogenase (GLDH), and lactate dehydrogenase (LDH), or any morphological hepatocellular injury. …
NAID 10026669477

Related Pictures

★リンクテーブル★

リンク元	「アデニル酸デアミナーゼ」「アデニル酸脱アミノ酵素」「アデノシン一リン酸デアミナーゼ」
拡張検索	「AMP deaminase deficiency」
関連記事	「A」「AM」「AMP」「deaminase」

「アデニル酸デアミナーゼ」

Adenosine monophosphate deaminase 1
Identifiers
Symbols	AMPD1 ; MAD; MADA
External IDs	OMIM: 102770 MGI: 88015 HomoloGene: 20 ChEMBL: 2869 GeneCards: AMPD1 Gene
EC number	3.5.4.6
Gene ontology
Molecular function	• AMP deaminase activity; • myosin heavy chain binding; • metal ion binding;
Cellular component	• cytosol;
Biological process	• purine nucleobase metabolic process; • response to organic substance; • IMP salvage; • purine-containing compound salvage; • small molecule metabolic process; • nucleobase-containing small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;