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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/22 14:30:31」(JST)
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Alkaline phosphatase, placental |
PDB PLAP dimer based on 1ZEF
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Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1EW2, 1ZEB, 1ZED, 1ZEF, 2GLQ, 3MK0, 3MK1, 3MK2
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Identifiers |
Symbols |
ALPP ; ALP; PALP; PLAP; PLAP-1 |
External IDs |
OMIM: 171800 MGI: 108009 HomoloGene: 122414 ChEMBL: 4458 GeneCards: ALPP Gene |
EC number |
3.1.3.1 |
Gene ontology |
Molecular function |
• magnesium ion binding
• alkaline phosphatase activity
• protein binding
• zinc ion binding
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Cellular component |
• plasma membrane
• cell surface
• integral component of membrane
• anchored component of membrane
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Biological process |
• protein dephosphorylation
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
250 |
76768 |
Ensembl |
ENSG00000163283 |
ENSMUSG00000079440 |
UniProt |
P05187 |
P24823 |
RefSeq (mRNA) |
NM_001632 |
NM_001081082 |
RefSeq (protein) |
NP_001623 |
NP_001074551 |
Location (UCSC) |
Chr 2:
232.38 – 232.38 Mb |
Chr 1:
87.1 – 87.1 Mb |
PubMed search |
[1] |
[2] |
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Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene.[1][2][3]
Contents
- 1 Gene
- 2 Function
- 3 Clinical significance
- 4 References
- 5 Further reading
Gene
There are at least four distinct but related alkaline phosphatases: intestinal (ALPI), placental (this enzyme), placental-like (ALPPL2), and liver/bone/kidney (ALPL) (tissue-nonspecific). The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2, and type 3) for this form of alkaline phosphatase have been well-characterized.[3]
Function
Alkaline phosphatase, placental type is a membrane-bound glycosylated dimeric enzyme, also referred to as the heat-stable form, that is expressed primarily in the placenta, although it is closely related to the intestinal form of the enzyme as well as to the placental-like form.[3]
Clinical significance
PLAP is a tumor marker, especially in seminoma[4][5][6][7] and ovarian cancer.[8] PLAP is reliable only in non-smokers, as smoking interferes with measurement of PLAP,[9] since serum concentrations of PLAP are increased up to 10-fold in smokers and its measurement is therefore of little value in this group.[10]
References
- ^ Kam W, Clauser E, Kim YS, Kan YW, Rutter WJ (Feb 1986). "Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA". Proc Natl Acad Sci U S A 82 (24): 8715–9. doi:10.1073/pnas.82.24.8715. PMC 391507. PMID 3001717.
- ^ Henthorn PS, Knoll BJ, Raducha M, Rothblum KN, Slaughter C, Weiss M, Lafferty MA, Fischer T, Harris H (Sep 1986). "Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids". Proc Natl Acad Sci U S A 83 (15): 5597–601. doi:10.1073/pnas.83.15.5597. PMC 386335. PMID 3461452.
- ^ a b c "Entrez Gene: ALPP alkaline phosphatase, placental (Regan isozyme)".
- ^ "European Group on Tumor Markers. A European Based Expert Group on Tumor Markers. Germ cell cancer.".
- ^ Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Fizazi K, Horwich A, Laguna MP (August 2011). "EAU guidelines on testicular cancer: 2011 update". Eur. Urol. 60 (2): 304–19. doi:10.1016/j.eururo.2011.05.038. PMID 21632173.
- ^ W. Albrecht; et al. (2004). "Testicular tumor markers: Corner-stones in the management of malignant germ cell tumors" (PDF). J Lab Med. 28 (2): 109–115. doi:10.1515/labmed.2004.018.
- ^ Sturgeon C (August 2002). "Practice guidelines for tumor marker use in the clinic". Clin. Chem. 48 (8): 1151–9. PMID 12142367.
- ^ Fishman WH (December 1987). "Clinical and biological significance of an isozyme tumor marker--PLAP". Clin. Biochem. 20 (6): 387–92. doi:10.1016/0009-9120(87)90003-8. PMID 3325192.
- ^ Schmoll HJ, Souchon R, Krege S, et al. (September 2004). "European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG)". Annals of Oncology 15 (9): 1377–99. doi:10.1093/annonc/mdh301. PMID 15319245.
- ^ "Tumor Markers in Testicular Cancers" (PDF).
Further reading
- Nye KE, Riley GA, Pinching AJ (1992). "The defect seen in the phosphatidylinositol hydrolysis pathway in HIV-infected lymphocytes and lymphoblastoid cells is due to inhibition of the inositol 1,4,5-trisphosphate 1,3,4,5-tetrakisphosphate 5-phosphomonoesterase.". Clin. Exp. Immunol. 89 (1): 89–93. doi:10.1111/j.1365-2249.1992.tb06883.x. PMC 1554388. PMID 1321014.
- Lowe ME (1992). "Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein.". J. Cell Biol. 116 (3): 799–807. doi:10.1083/jcb.116.3.799. PMC 2289307. PMID 1730777.
- Micanovic R, Gerber LD, Berger J, Kodukula K, Udenfriend S (1990). "Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.". Proc. Natl. Acad. Sci. U.S.A. 87 (1): 157–61. doi:10.1073/pnas.87.1.157. PMC 53219. PMID 2153284.
- Martin D, Spurr NK, Trowsdale J (1988). "RFLP of the human placental alkaline phosphatase gene (PLAP).". Nucleic Acids Res. 15 (21): 9104. doi:10.1093/nar/15.21.9104. PMC 306450. PMID 2891112.
- Knoll BJ, Rothblum KN, Longley M (1988). "Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution.". J. Biol. Chem. 263 (24): 12020–7. PMID 3042787.
- Micanovic R, Bailey CA, Brink L, Gerber L, Pan YC, Hulmes JD, Udenfriend S (1988). "Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.". Proc. Natl. Acad. Sci. U.S.A. 85 (5): 1398–402. doi:10.1073/pnas.85.5.1398. PMC 279778. PMID 3422741.
- Knoll BJ, Rothblum KN, Longley M (1988). "Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.". Gene 60 (2-3): 267–76. doi:10.1016/0378-1119(87)90235-6. PMID 3443302.
- Ovitt CE, Strauss AW, Alpers DH, Chou JY, Boime I (1986). "Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells.". Proc. Natl. Acad. Sci. U.S.A. 83 (11): 3781–5. doi:10.1073/pnas.83.11.3781. PMC 323607. PMID 3459156.
- Millán JL (1986). "Molecular cloning and sequence analysis of human placental alkaline phosphatase.". J. Biol. Chem. 261 (7): 3112–5. PMID 3512548.
- Ezra E, Blacher R, Udenfriend S (1984). "Purification and partial sequencing of human placental alkaline phosphatase.". Biochem. Biophys. Res. Commun. 116 (3): 1076–83. doi:10.1016/S0006-291X(83)80252-6. PMID 6651840.
- Le Du MH, Stigbrand T, Taussig MJ, Menez A, Stura EA (2001). "Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.". J. Biol. Chem. 276 (12): 9158–65. doi:10.1074/jbc.M009250200. PMID 11124260.
- Spurway TD, Dalley JA, High S, Bulleid NJ (2001). "Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p.". J. Biol. Chem. 276 (19): 15975–82. doi:10.1074/jbc.M010128200. PMID 11278620.
- Rump A, Kasper G, Hayes C, Wen G, Starke H, Liehr T, Lehmann R, Lagemann D, Rosenthal A (2001). "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1.". Genomics 73 (1): 50–5. doi:10.1006/geno.2000.6504. PMID 11352565.
- Wennberg C, Kozlenkov A, Di Mauro S, Fröhlander N, Beckman L, Hoylaerts MF, Millán JL (2002). "Structure, genomic DNA typing, and kinetic characterization of the D allozyme of placental alkaline phosphatase (PLAP/ALPP).". Hum. Mutat. 19 (3): 258–67. doi:10.1002/humu.10052. PMID 11857742.
- Kozlenkov A, Manes T, Hoylaerts MF, Millán JL (2002). "Function assignment to conserved residues in mammalian alkaline phosphatases.". J. Biol. Chem. 277 (25): 22992–9. doi:10.1074/jbc.M202298200. PMID 11937510.
- Tang J, Li W (2002). "[Methodological study on the assay of glycosylphosphatidylinositol-specific phospholipase D activity in serum]". Hunan Yi Ke Da Xue Xue Bao 24 (2): 119–22. PMID 11938765.
- Lehto MT, Sharom FJ (2002). "Proximity of the protein moiety of a GPI-anchored protein to the membrane surface: a FRET study.". Biochemistry 41 (26): 8368–76. doi:10.1021/bi012038. PMID 12081485.
- Le Du MH, Millan JL (2003). "Structural evidence of functional divergence in human alkaline phosphatases.". J. Biol. Chem. 277 (51): 49808–14. doi:10.1074/jbc.M207394200. PMID 12372831.
- Llinas P, Stura EA, Ménez A, Kiss Z, Stigbrand T, Millán JL, Le Du MH (July 2005). "Structural studies of human placental alkaline phosphatase in complex with functional ligands". J. Mol. Biol. 350 (3): 441–51. doi:10.1016/j.jmb.2005.04.068. PMID 15946677.
PDB gallery
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1ew2: CRYSTAL STRUCTURE OF A HUMAN PHOSPHATASE
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1zeb: X-ray structure of alkaline phosphatase from human placenta in complex with 5'-AMP
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1zed: Alkaline phosphatase from human placenta in complex with p-nitrophenyl-phosphonate
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1zef: structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor L-Phe
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2glq: X-ray structure of human alkaline phosphatase in complex with strontium
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Hydrolase: esterases (EC 3.1)
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3.1.1: Carboxylic
ester hydrolases |
- Cholinesterase
- Acetylcholinesterase
- Butyrylcholinesterase
- Pectinesterase
- 6-phosphogluconolactonase
- PAF acetylhydrolase
- Lipase
- Bile salt-dependent
- Gastric/Lingual
- Pancreatic
- Lysosomal
- Hormone-sensitive
- Endothelial
- Hepatic
- Lipoprotein
- Monoacylglycerol
- Diacylglycerol
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3.1.2: Thioesterase |
- Palmitoyl protein thioesterase
- Ubiquitin carboxy-terminal hydrolase L1
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3.1.3: Phosphatase |
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Protein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Protein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
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3.1.4: Phosphodiesterase |
- Autotaxin
- Phospholipase
- Sphingomyelin phosphodiesterase
- PDE1
- PDE2
- PDE3
- PDE4A/PDE4B
- PDE5
- Lecithinase (Clostridium perfringens alpha toxin)
- Cyclic nucleotide phosphodiesterase
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3.1.6: Sulfatase |
- arylsulfatase
- Arylsulfatase A
- Arylsulfatase B
- Arylsulfatase E
- Steroid sulfatase
- Galactosamine-6 sulfatase
- Iduronate-2-sulfatase
- N-acetylglucosamine-6-sulfatase
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Nuclease (includes
deoxyribonuclease and
ribonuclease) |
3.1.11-16: Exonuclease |
Exodeoxyribonuclease |
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Exoribonuclease |
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3.1.21-31: Endonuclease |
Endodeoxyribonuclease |
- Deoxyribonuclease I
- Deoxyribonuclease II
- Deoxyribonuclease IV
- Restriction enzyme
- UvrABC endonuclease
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Endoribonuclease |
- RNase III
- RNase H
- RNase P
- RNase A
- RNase T1
- RNA-induced silencing complex
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either deoxy- or ribo- |
- Aspergillus nuclease S1
- Micrococcal nuclease
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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English Journal
- Surgeon-tailored polypropylene mesh as a needleless single-incision sling versus TVT-O for the treatment of female stress urinary incontinence: a comparative study.
- ElSheemy MS1, Fathy H, Hussein HA, Hussein EA, Hassan SM.
- International urology and nephrology.Int Urol Nephrol.2015 Jun;47(6):937-44. doi: 10.1007/s11255-015-0974-4. Epub 2015 Apr 22.
- PURPOSE: To compare safety and efficacy of surgeon-tailored polypropylene mesh through needleless single-incision technique (STM) versus tension-free vaginal tape-obturator (TVT-O) aiming to decrease cost of treatment of stress urinary incontinence (SUI). This is important in developing countries du
- PMID 25899765
- Ectoenzyme switches the surface of magnetic nanoparticles for selective binding of cancer cells.
- Du X1, Zhou J1, Xu B2.
- Journal of colloid and interface science.J Colloid Interface Sci.2015 Jun 1;447:273-7. doi: 10.1016/j.jcis.2014.12.023. Epub 2014 Dec 24.
- Enzymatic switch, such as phosphorylation and dephosphorylation of proteins, is the most important mechanism for cellular signal transductions. Inspired by Nature and encouraged by our recent unexpected observation of the dephosphorylation of d-tyrosine phosphate-contain small peptides, we modify th
- PMID 25586118
- Chronological Urodynamic Evaluation of Changing Bladder and Urethral Functions After Robot-assisted Radical Prostatectomy.
- Kadono Y1, Ueno S2, Iwamoto D2, Takezawa Y2, Nohara T2, Izumi K2, Mizokami A2, Namiki M2.
- Urology.Urology.2015 Jun;85(6):1441-7. doi: 10.1016/j.urology.2015.02.029. Epub 2015 Apr 8.
- OBJECTIVE: To examine chronological changes in urethral and bladder functions before, immediately after, and 1 year after robot-assisted radical prostatectomy (RARP), urodynamic studies were prospectively performed.METHODS: Sixty-three consecutive patients underwent pressure-flow studies, urethral
- PMID 25863842
Japanese Journal
- Chronological urodynamic evaluation of changing bladder and urethral functions after robot-assisted radical prostatectomy
- Kadono Yoshifumi,Ueno Satoru,Iwamoto Daiki,Takezawa Yuta,Nohara Takahiro,Izumi Kouji,Mizokami Atsushi,Namiki Mikio
- Urology 85(6), 1441-1447, 2015-06-01
- … Methods Sixty-three consecutive patients underwent pressure-flow studies, urethral pressure profiles, and abdominal leak point pressure (ALPP) tests 1-2 days before, immediately after, and 1 year after RARP. … Intrinsic sphincter deficiency (ISD) evaluated by the ALPP test was observed in 53 patients immediately after RARP, although no patient showed ISD before RARP. … Both ALPP and maximum urethral closure pressure at 1 year were significant factors for continence in multivariate analysis. …
- NAID 120005647652
- Urodynamic evaluation before and immediately after robot-assisted radical prostatectomy
- Kadono Yoshifumi,Ueno Satoru,Yaegashi Hiroshi,Ofude Mitsuo,Izumi Kouji,Maeda Yuji,Mizokami Atsushi,Miwa Sotaro,Miyagi Tohru,Namiki Mikio
- Urology 84(1), 106-111, 2014
- … Filling cystometry, urethral pressure profilometry, and abdominal leak point pressure (ALPP) tests were performed before and immediately after RARP. … No urine leakage was observed in ALPP test preoperatively; … however, urine leakage was observed postoperatively in 75 patients (86%), with a mean ALPP of 47.7 cm H2O. … Multivariate analysis revealed that MCC, MUCP, and ALPP after RARP were predictive factors for ULR. …
- NAID 120005463338
- 尿失禁患者の問診,検査のすすめ方 (焦点 女性の尿失禁:最新の治療とケア)
Related Links
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Related Pictures
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アルカリホスファターゼ alkaline phosphatase