関: AKR mouse、inbred AKR mice

WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
the syllable naming the third (mediant) note of any major scale in solmization

PrepTutorEJDIC

answer / ampere
ミ(全音階の第3音)
mouseの複数形
Alaska

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1. 遺伝学およびゲノミクスのためのツール：研究用に育種された遺伝子改変マウス tools for genetics and genomics specially bred and genetically engineered mice
2. レプチンの生理学 physiology of leptin
3. 肥満の病因 pathogenesis of obesity
4. 1型糖尿病の予防 prevention of type 1 diabetes mellitus
5. 1型糖尿病の病因 pathogenesis of type 1 diabetes mellitus

English Journal

Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes.

Schumacher D, Morgenstern J, Oguchi Y, Volk N, Kopf S, Groener JB, Nawroth PP, Fleming T, Freichel M.
Molecular metabolism. 2018 Dec;18()143-152.
The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one the five mechanisms by which hyperglycemia causes diabetic late complications. Aldo-keto reductases (AKR) have been shown to metabolize MG; however, the relative contribution of this supe
PMID 30287091

Preventive Effects of Fermented Brown Rice and Rice Bran on Spontaneous Lymphomagenesis in AKR/NSlc Female Mice

Kuno T, Kato H, Naiki-Ito A, Suzuki S, Tanaka T, Takahashi S, Mori H.
Asian Pacific journal of cancer prevention : APJCP. 2018 Nov;19(11)3217-3223.
Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) is known to possess potentials to prevent

chemical carcinogenesis in multiple organs of rodents. In the present study, possible chemopreventive effect of FBRA against spontaneous occurrence of lymphomas was examined using female AKR/N

PMID 30486615

Abnormal Morphology of Distal Tubular Epithelial Cells Is Regulated by Genetic Factors Derived from Mouse Chromosome 12.

Ichii O, Nakamura T, Horino T, Yabuki A, Elewa YHA, Kon Y.
The American journal of pathology. 2018 Sep;188(9)2120-2138.
The distal tubule (DT) helps regulate blood pressure and electrolytes. We describe a novel, autosomal recessive, morphofunctional DT abnormality in inbred mice evident as columnar alternations and age-related cystic changes. This abnormality developed in both sexes of DBA/2Cr. Similar phenotypes wer
PMID 29935167

Japanese Journal

Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance

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Endocrine Journal advpub(0), 2015
… Using C57BL/6, C3H, and AKR as background strains, mice showing inferior and superior glucose tolerance after HFD feeding were selected and bred repetitively over 20 generations to produce SDG-P and SDG-R, respectively. … As the generations proceeded, SDG-P mice became more susceptible to HFD-induced glucose intolerance and body weight gain, whereas SDG-R mice had gradually reduced HFD intake. …
NAID 130004770494

Pathogenetic role of an autoimmune susceptibility locus derived from MRL/MpJ strain chromosome 1 in chronic pancreas inflammation

Okada Yuki,Nakamura Teppei,Ichii Osamu,Otsuka Saori,Kon Yasuhiro
Lupus 23(11), 1112-1123, 2014-10
… Pancreatic periductal/perivascular cell infiltration was observed frequently in A/J, AKR/N, B6.MRLc1, C57BL/6, and MRL/MpJ, moderately in DBA/1 and DBA/2, and rarely in BALB/c and C3H/He strains. … C57BL/6 mice possessed defined borders between cell infiltrations and acini, but borders were indistinct in MRL/MpJ and B6.MRLc1 mice. …
NAID 120005476208

Relationship between Numerous Mast Cells and Early Follicular Development in Neonatal MRL/MpJ Mouse Ovaries

Nakamura Teppei,Otsuka Saori,Ichii Osamu,Sakata Yuko,Nagasaki Ken-Ichi,Hashimoto Yoshiharu,Kon Yasuhiro
PLoS One 8(10), e77246, 2013-10-04
… During this period, we found numerous mast cells in the ovary of MRL/MpJ mice and investigated their appearance and morphology with follicular development. … Among 11 different mouse strains, MRL/MpJ mice possessed the greatest number of ovarian mast cells. … Ovarian mast cells were also found in DBA/1, BALB/c, NZW, and DBA/2 mice but rarely in C57BL/6, NZB, AKR, C3H/He, CBA, and ICR mice. …
NAID 120005350092