関: ATP receptor、P2 purinoceptor、purinergic P2 receptor

WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
in the Christian era; used before dates after the supposed year Christ was born; "in AD 200" (同)A.D., anno_Domini

PrepTutorEJDIC

answer / ampere
=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/20 17:12:53」(JST)

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P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans: P2Y₁, P2Y₂, P2Y₄, P2Y₅, P2Y₆, P2Y₈, P2Y₉ (present in NCBI as GPR23), P2Y₁₀, P2Y₁₁, P2Y₁₂, P2Y₁₃ and P2Y₁₄.^[1]

P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling.

Coupling[edit]

The biological effects of P2Y receptor activation depends on how they couple to downstream signalling pathways, either via G_i, G_q/11 or G_s G proteins. Human P2Y receptors have the following G protein coupling:

Protein	Gene	Coupling	Nucleotide
P2RY₁	P2RY1	G_q/11	ADP
P2RY₂	P2RY2	G_q/11	ATP, UTP
P2RY₄	P2RY4	G_i and G_q/11	UTP
P2RY₅ / LPA₆	LPAR6		Lysophosphatidic acid^[2]
P2RY₆	P2RY6	G_q/11	UDP
P2RY₈	P2RY8		orphan receptor
P2RY₉ / LPAR₄ / GPR23	LPAR4		Lysophosphatidic acid
P2RY₁₀	P2RY10		orphan receptor
P2RY₁₁	P2RY11	G_s and G_q/11	ATP
P2RY₁₂	P2RY12	G_i	ADP
P2RY₁₃	P2RY13	G_i	ADP
P2RY₁₄	P2RY14	G_i	UDP-glucose

The gaps in P2Y receptor numbering is due to that several receptors (P2Y₃, P2Y₅, P2Y₇, P2Y₈, P2Y₉, P2Y₁₀) were thought to be P2Y receptors when they were cloned, when in fact they are not.

Clinical significance[edit]

P2Y₂ is a potential drug target for treating cystic fibrosis.^[3]

P2Y₁₁ is a regulator of immune response, and a common polymorphism carried by almost 20% of North European caucasians give increased risk of myocardial infarction, making P2Y₁₁ an interesting drug target candidate for treatment of myocardial infarction.^[4]

P2Y₁₂ is the target of the anti-platelet drug clopidogrel^[5] and other thienopyridines.

References[edit]

^ Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA (2006). "International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy". Pharmacol. Rev. 58 (3): 281–341. doi:10.1124/pr.58.3.3. PMID 16968944.
^ Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC. "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth." Nature Genetics 2008 Mar;40(3):329-34. PMID 18297070
^ Kellerman D, Evans R, Mathews D, Shaffer C (2002). "Inhaled P2Y₂ receptor agonists as a treatment for patients with Cystic Fibrosis lung disease". Adv. Drug Deliv. Rev. 54 (11): 1463–74. doi:10.1016/S0169-409X(02)00154-0. PMID 12458155.
^ Amisten S, Melander O, Wihlborg AK, Berglund G, Erlinge D (2007). "Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y₁₁". Eur. Heart J. 28 (1): 13–8. doi:10.1093/eurheartj/ehl410. PMID 17135283.
^ Herbert JM, Savi P (2003). "P2Y12, a new platelet ADP receptor, target of clopidogrel". Seminars in vascular medicine 3 (2): 113–22. doi:10.1055/s-2003-40669. PMID 15199474.

External links[edit]

Ivar von Kügelgen: Pharmacology of mammalian P2X- and P2Y-receptors, BIOTREND Reviews No. 03, September 2008,© 2008 BIOTREND Chemicals AG
"P2Y Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Purinergic P2 receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

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Astrocytes express a variety of purinergic (P2) receptors, involved in astrocytic communication through fast increases in [Ca(2+) ]i . Of these, the metabotropic ATP receptors (P2Y) regulate cytoplasmic Ca(2+) levels through the PLC-PKC pathway. GABA transporters are a substrate for a number of Ca(2
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Colistin-Induced Nephrotoxicity in Mice Involves the Mitochondrial, Death Receptor, and Endoplasmic Reticulum Pathways.

Dai C1, Li J2, Tang S1, Li J3, Xiao X4.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014 Jul;58(7):4075-4085. Epub 2014 May 5.
Nephrotoxicity is the dose-limiting factor for colistin, but the exact mechanism is unknown. This study aimed to investigate the roles of the mitochondrial, death receptor, and endoplasmic reticulum pathways in colistin-induced nephrotoxicity. Mice were intravenously administered 7.5 or 15 mg of col
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「purinergic P2 receptor」

　　[★]

プリンP2受容体、P2プリン受容体

関: ADP receptor、ATP receptor、P2 purinergic receptor、P2 purinoceptor、P2 receptor

「P2 purinoceptor」

　　[★]

P2プリン受容体

関: ADP receptor、ATP receptor、P2 purinergic receptor、P2 receptor、purinergic P2 receptor

「ADP受容体」

　　[★]

英: ADP receptor
関: ATP受容体、プリンP2受容体、P2プリン受容体、ADPレセプター

「ATP receptor」

　　[★]

ATP受容体、ATPレセプター

関: ADP receptor、P2 purinoceptor、purinergic P2 receptor

「ADPレセプター」

　　[★]

英: ADP receptor
関: ADP受容体

「ADP」

　　[★]

アデノシン二リン酸 adenosine diphosphate adenosine 5'-diphosphate
5-aminolevulinic acid dehydratase porphyria
母指内転筋 adductor pollicis

「A」

　　[★]

「AD」

　　[★]

[pmid16968944-1] Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA (2006). "International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy". Pharmacol. Rev. 58 (3): 281–341. doi:10.1124/pr.58.3.3. PMID 16968944.

[2] Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC. "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth." Nature Genetics 2008 Mar;40(3):329-34. PMID 18297070

[pmid12458155-3] Kellerman D, Evans R, Mathews D, Shaffer C (2002). "Inhaled P2Y₂ receptor agonists as a treatment for patients with Cystic Fibrosis lung disease". Adv. Drug Deliv. Rev. 54 (11): 1463–74. doi:10.1016/S0169-409X(02)00154-0. PMID 12458155.

[pmid17135283-4] Amisten S, Melander O, Wihlborg AK, Berglund G, Erlinge D (2007). "Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y₁₁". Eur. Heart J. 28 (1): 13–8. doi:10.1093/eurheartj/ehl410. PMID 17135283.

[pmid15199474-5] Herbert JM, Savi P (2003). "P2Y12, a new platelet ADP receptor, target of clopidogrel". Seminars in vascular medicine 3 (2): 113–22. doi:10.1055/s-2003-40669. PMID 15199474.

リンク元	「purinergic P2 receptor」「P2 purinoceptor」「ADP受容体」「ATP receptor」「ADPレセプター」
関連記事	「ADP」「A」「AD」

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案内

ADP receptor