関: ARF1

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
in the Christian era; used before dates after the supposed year Christ was born; "in AD 200" (同)A.D., anno_Domini

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
answer / ampere

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/27 16:52:20」(JST)

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ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.^[1]

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[2]

Interactions

ARF1 has been shown to interact with GGA3,^[3]^[4] PLD2,^[5]^[6] COPB1^[7]^[8] and Muscarinic acetylcholine receptor M3.^[9]

References

^ Lee CM, Haun RS, Tsai SC, Moss J, Vaughan M (June 1992). "Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin". J Biol Chem 267 (13): 9028–34. PMID 1577740.
^ "Entrez Gene: ARF1 ADP-ribosylation factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=375.
^ Dell'Angelica, E C; Puertollano R, Mullins C, Aguilar R C, Vargas J D, Hartnell L M, Bonifacino J S (April 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J. Cell Biol. (UNITED STATES) 149 (1): 81–94. doi:10.1083/jcb.149.1.81. ISSN 0021-9525. PMC 2175099. PMID 10747089. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2175099/.
^ Puertollano, R; Randazzo P A, Presley J F, Hartnell L M, Bonifacino J S (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell (United States) 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. ISSN 0092-8674. PMID 11301005.
^ Lee, S; Park J B, Kim J H, Kim Y, Kim J H, Shin K J, Lee J S, Ha S H, Suh P G, Ryu S H (July 2001). "Actin directly interacts with phospholipase D, inhibiting its activity". J. Biol. Chem. (United States) 276 (30): 28252–60. doi:10.1074/jbc.M008521200. ISSN 0021-9258. PMID 11373276.
^ Park, J B; Kim J H, Kim Y, Ha S H, Yoo J S, Du G, Frohman M A, Suh P G, Ryu S H (July 2000). "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner". J. Biol. Chem. (UNITED STATES) 275 (28): 21295–301. doi:10.1074/jbc.M002463200. ISSN 0021-9258. PMID 10801846.
^ Fischer, K D; Helms J B, Zhao L, Wieland F T (April 2000). "Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles". Methods (UNITED STATES) 20 (4): 455–64. doi:10.1006/meth.2000.0958. ISSN 1046-2023. PMID 10720466.
^ Eugster, A; Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. (ENGLAND) 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. ISSN 0261-4189. PMC 306616. PMID 10921873. //www.ncbi.nlm.nih.gov/pmc/articles/PMC306616/.
^ Mitchell, Rory; Robertson Derek N, Holland Pamela J, Collins Daniel, Lutz Eve M, Johnson Melanie S (September 2003). "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem. (United States) 278 (36): 33818–30. doi:10.1074/jbc.M305825200. ISSN 0021-9258. PMID 12799371.

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English Journal

Conformational States of ADP Ribosylation Factor 1 Complexed with Different Guanosine Triphosphates As Studied by (31)P NMR Spectroscopy.

Meierhofer T, Eberhardt M, Spoerner M.SourceUniversity of Regensburg , Institute of Biophysics and Physical Biochemistry, Universitatsstrasse 31, D-93053 Regensburg, Germany.
Biochemistry.Biochemistry.2011 Jul 26;50(29):6316-27. Epub 2011 Jul 5.
Guanine nucleotide binding proteins (GNB-proteins) play an essential role in cellular signaling, acting as molecular switches, cycling between the inactive, GDP-bound form and the active, GTP-bound form. It has been shown that conformational equilibria also exist within the active form of GNB-protei
PMID 21702511

Role of Arf1 in endosomal trafficking of protein-metal complexes and cadmium-metallothionein-1 toxicity in kidney proximal tubule cells.

Wolff NA, Lee WK, Thevenod F.SourceInstitute of Physiology & Pathophysiology, University of Witten/Herdecke, Stockumer Strasse 12, D-58453 Witten, Germany.
Toxicology letters.Toxicol Lett.2011 Jun 24;203(3):210-8. Epub 2011 Mar 21.
Cadmium (Cd) is nephrotoxic. Circulating Cd-metallothionein complexes (CdMT) are filtered by the kidney, reabsorbed by proximal tubule cells (PTC) via receptor-mediated endocytosis, and trafficked to lysosomes which results in apoptosis. ADP-ribosylation factors (Arfs) regulate vesicular trafficking
PMID 21421027

Japanese Journal

胎児発育におけるビオチンの役割についての研究

渡邊敏明
ビタミン 84(7), 301-312, 2010-07-25
… Protein expression in adenosine diphosphate (ADP)-ribosylation factor 2 and α-crystallin may be down-regulated in the mesenchyme of the palatal processes.As for the bioavailability of biotin during gestation, a large amount of biotin was transported to palates and mandibles on dg 12-15 (day of gestation). …
NAID 110007682285

The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons

Suzuki Atsushi,Arikawa Chihiro,Kuwahara Yuji,Itoh Kouichi,Watanabe Masatomo,Watanabe Hiroshi,Suzuki Teruhiko,Funakoshi Yuji,Hasegawa Hiroshi,Kanaho Yasunori,船越祐司,長谷川潤,金保安則
FEBS letters 584(13), 2801-2806, 2010-07
… The small GTPase ADP-ribosylation factor 6 (ARF6) plays crucial roles in a wide variety of cell functions. …
NAID 120002233499

Related Pictures

★リンクテーブル★

リンク元	「ADP-リボシル化因子1」「ADPリボシル化因子1」「ARF1」
関連記事	「ADP」「fact」「factor」「A」「ribosylation」

「ADP-リボシル化因子1」

ADP-ribosylation factor 1
	; PDB rendering based on 1hur.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1HUR, 1RE0, 1U81, 3O47
Identifiers
Symbol	ARF1
External IDs	OMIM: 103180 MGI: 99431 HomoloGene: 56086 ChEMBL: 5985 GeneCards: ARF1 Gene
Gene Ontology
Molecular function	• GTPase activity; • receptor signaling protein activity; • protein binding; • GTP binding;
Cellular component	• Golgi membrane; • cytosol; • plasma membrane; • sarcomere; • perinuclear region of cytoplasm;
Biological process	• GTP catabolic process; • cellular copper ion homeostasis; • retrograde vesicle-mediated transport, Golgi to ER; • post-Golgi vesicle-mediated transport; • small GTPase mediated signal transduction; • protein transport; • viral reproduction; • cellular membrane organization; • COPI coating of Golgi vesicle; • regulation of defense response to virus by virus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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