ACTH therapy

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英文文献

  • Effects of escitalopram/quetiapine combination therapy versus escitalopram monotherapy on hypothalamic-pituitary-adrenal-axis activity in relation to antidepressant effectiveness.
  • Nothdurfter C1, Schmotz C2, Sarubin N3, Baghai TC4, Laenger A5, Lieb M4, Bondy B5, Rupprecht R4, Schüle C5.Author information 1Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053 Regensburg, Germany. Electronic address: Caroline.Nothdurfter@medbo.de.2Isar-Amper Klinikum München-Ost, Vockestrasse 72, 85540 Haar, Germany.3Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053 Regensburg, Germany; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany.4Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053 Regensburg, Germany.5Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany.AbstractThe hypothalamic-pituitary-adrenocortical (HPA) system is believed to play an important role in the pathophysiology of major depressive disorder. In this context, the atypical antipsychotic quetiapine (QUE) has been shown to inhibit HPA system activity in healthy subjects. In this study we investigated whether the putative inhibitory effects of QUE on HPA system activity may contribute to its antidepressant efficacy. We analyzed the effects of QUE as an augmentation to the selective serotonin reuptake inhibitor (SSRI) escitalopram (ESC) on HPA system activity in comparison to a monotherapy with ESC in relation to the antidepressant effectiveness. HPA axis activity (cortisol and ACTH) was measured by means of the dexamethasone/corticotropin-releasing hormone (DEX/CRH) test which was performed before (week 0) and during (week 1, week 5) antidepressant psychopharmacotherapy. The combination therapy, but not the ESC monotherapy showed significantly inhibiting effects on HPA system activity leading to stepwise down-regulation. ACTH concentrations were reduced in the ESC/QUE group during five weeks of treatment. The inhibitory effect of QUE maybe involved in its antidepressant effects as an augmentation strategy.
  • Journal of psychiatric research.J Psychiatr Res.2014 May;52:15-20. doi: 10.1016/j.jpsychires.2014.01.013. Epub 2014 Jan 31.
  • The hypothalamic-pituitary-adrenocortical (HPA) system is believed to play an important role in the pathophysiology of major depressive disorder. In this context, the atypical antipsychotic quetiapine (QUE) has been shown to inhibit HPA system activity in healthy subjects. In this study we investiga
  • PMID 24513501
  • High Response Rates and Prolonged Survival in Patients With Corticotroph Pituitary Tumors and Refractory Cushing Disease From Capecitabine and Temozolomide (CAPTEM): A Case Series.
  • Zacharia BE1, Gulati AP, Bruce JN, Carminucci AS, Wardlaw SL, Siegelin M, Remotti H, Lignelli A, Fine RL.Author information 1*Department of Neurological Surgery, ‡Experimental Therapeutics Program, Department of Medicine, Division of Medical Oncology, Pancreas Center at Columbia, §Department of Medicine, Neuroendocrine Unit, and ¶Department of Pathology, Herbert Irving Comprehensive Cancer Center, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY.AbstractBACKGROUND AND IMPORTANCE: Rarely, corticotrophic pituitary tumors take on an aggressive form characterized by rapid growth, invasion into local structures, compression of cranial nerves, and possible spread to distant sites. When conventional surgery, radiation therapy, and hormones fail to control progression and symptoms, alternative therapies are needed. A novel chemotherapeutic regimen of capecitabine and temozolomide (CAPTEM), originally designed in our laboratory, demonstrated dramatic antineoplastic effects against corticotrophic pituitary tumors.
  • Neurosurgery.Neurosurgery.2014 Apr;74(4):E447-55. doi: 10.1227/NEU.0000000000000251.
  • BACKGROUND AND IMPORTANCE: Rarely, corticotrophic pituitary tumors take on an aggressive form characterized by rapid growth, invasion into local structures, compression of cranial nerves, and possible spread to distant sites. When conventional surgery, radiation therapy, and hormones fail to control
  • PMID 24226425

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関連リンク

最近は、食べ物ネタが続いてしまっているので、時には仕事の話も書きます。長文です。気合いを入れて読んでくださいね。 こちらで、つい最近、 点頭てんかん(West syndrome)の患者のACTH療法 に関わったのですが、今まで日本で行って ...
1. Epilepsia. 2005 May;46(5):709-15. Effect of ACTH therapy for epileptic spasms without hypsarrhythmia. Oguni H, Funatsuka M, Sasaki K, Nakajima T, Yoshii K, Nishimura T, Osawa M. Department of Pediatrics ...

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★リンクテーブル★
関連記事therapy」「ACT」「ACTH」「AC

therapy」

  [★]

  • n.
carecurecuringpracticepsychotherapyregimenremediationremedytherapeutictreattreatmenttreatment protocol

PrepTutorEJDIC   license prepejdic

「(病気の)治療,療法 / =psychotherapy」

WordNet   license wordnet

「(medicine) the act of caring for someone (as by medication or remedial training etc.); "the quarterback is undergoing treatment for a knee injury"; "he tried every treatment the doctors suggested"; "heat therapy gave the best relief"」


ACT」

  [★]

PrepTutorEJDIC   license prepejdic

「American College Testing / Australian Capital Territory」


ACTH」

  [★] 副腎皮質刺激ホルモン adrenocorticotropic hormone

PrepTutorEJDIC   license prepejdic

「副腎皮質刺激ホルモン[剤]」


AC」

  [★]





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