関: 6-aminocaproic acid、epsilon-aminocaproic acid

WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/28 22:23:49」(JST)

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Aminocaproic acid (also known as Amicar, ε-aminocaproic acid, ε-Ahx, or 6-aminohexanoic acid) is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis. For this reason it is effective in treatment of certain bleeding disorders, and it is marketed as Amicar. Aminocaproic acid is also an intermediate in the polymerization of Nylon-6, where it is formed by ring-opening hydrolysis of caprolactam.

Clinical use[edit]

Aminocaproic acid is used to treat excessive postoperative bleeding, especially after procedures in which a great amount of bleeding is expected, such as cardiac surgery. It can be given orally or intravenously. A meta-analysis found that lysine analogs like aminocaproic acid significantly reduced blood loss in patients undergoing coronary artery bypass grafting.

Aminocaproic acid can also be used to treat the overdose and/or toxic effects of the thrombolytic pharmacologic agents tissue plasminogen activator (commonly known as tPA) and streptokinase.

Side effects[edit]

Its side effects include nausea, vomiting, and chronic mild fevers (37.2 to 37.8 °C). When used long-term (for approximately 6 to 12 months), there is a risk of the inflammation of one's internal organs, especially the appendix (appendicitis) and liver, as well as failure of the liver and cyanosis. It almost always causes generalized myalgia and fibromyalgia. In some cases, successive organ failure can occur after long-term usage. However, the main risk associated with aminocaproic acid is the increased risk for thrombosis because of the inhibition of fibrinolysis.

References[edit]

1. ^Alkjaersig, N et al. (1959). ε-Aminocaproic Acid: an Inhibitor of Plasminogen Activation. J. Biol. Chem. 234: 832-837.

2. ^Kang, Y et al. (1987).Epsilon-aminocaproic Acid for Treatment of Fibrinolysis during Liver Transplantation. Anesthesiology. 66(6): 766–773.

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English Journal

Kinetic uptake profiles of cell penetrating peptides in lymphocytes and monocytes.

Rodrigues M, de la Torre BG, Andreu D, Santos NC.SourceInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1830(10):4554-63. doi: 10.1016/j.bbagen.2013.05.020. Epub 2013 May 24.
BACKGROUND: Nucleolar targeting peptides (NrTPs), resulting from structural minimization of the rattlesnake toxin crotamine, are a novel family of cell-penetrating peptides (CPPs) shown to internalize and deliver cargos into different cell types.METHODS: In this study, we address NrTP kinetics of tr
PMID 23707662

A new pyruvate oxidase biosensor based on 3-mercaptopropionic acid/6-aminocaproic acid modified gold electrode.

Bayram E, Akyilmaz E.SourceFaculty of Science, Department of Biochemistry, Ege University , Bornova-İzmir , Turkey.
Artificial cells, nanomedicine, and biotechnology (Print).Artif Cells Nanomed Biotechnol.2013 Jul 24. [Epub ahead of print]
In the biosensor construction, 3-mercaptopropionic acid (3-MPA) and 6-aminocaproic acid (6-ACA) were used for forming self-assembled monolayer (SAM) on a gold disc electrode and pyruvate oxidase was immobilized on the modified electrode surface by using glutaraldehyde. Biosensor response is linearly
PMID 23879219

Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model.

Kostousov V, Wang YW, Cotton BA, Wade CE, Holcomb JB, Matijevic N.SourceCenter for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.Blood Coagul Fibrinolysis.2013 Jul;24(5):489-97. doi: 10.1097/MBC.0b013e32835e4246.
Hyperfibrinolysis has been identified as a mechanism of trauma coagulopathy associated with poor outcome. The aim of the study was to create a trauma coagulopathy model (TCM) with a hyperfibrinolysis thrombelastography (TEG) pattern similar to injured patients and test the effects of different resus
PMID 23406662

Japanese Journal

1E14-4 Alcaligenes sp. IFO14130の菊酸エチルエステルと6-アミノヘキサン酸環状ダイマーに作用する加水分解酵素の関係(生物化学工学,一般講演)

満倉浩一,清水美佳,松下恭子,吉田豊和,長澤透
日本生物工学会大会講演要旨集平成17年度, 146, 2005-09-25
NAID 110007321473

Preparation and Characterization of Fully Active Biotinylated Analogs of Phytosulfokine-α

MATSUBAYASHI Yoshikatsu,TAKAHATA Yoshinori,MORITA Akiko,ATSUMI Keisuke,SAKAGAMI Youji
Bioscience, biotechnology, and biochemistry 63(10), 1847-1849, 1999-10-23
… Insertion of a single or double 6-aminohexanoic acid spacer between the ε amino group of Lys^5 and the carboxyl group of biotin did not significantly alter the activities of biotinylated [Lys^5] PSK-α. …
NAID 110002692020

「イプシロンアミノカプロン酸」

Aminocaproic acid
Systematic (IUPAC) name
	6-aminohexanoic acid
Clinical data
Trade names	Amicar
AHFS/Drugs.com	monograph
MedlinePlus	a608023
Pregnancy cat.	?
Legal status	℞ Prescription only
Pharmacokinetic data
Metabolism	Renal
Half-life	2 hours
Identifiers
CAS number	60-32-2
ATC code	B02AA01
PubChem	CID 564
DrugBank	DB00513
ChemSpider	548
UNII	U6F3787206
KEGG	D00160
ChEBI	CHEBI:16586
ChEMBL	CHEMBL1046
NIAID ChemDB	018631
Chemical data
Formula	C6H13NO2
Mol. mass	131.173 g/mol
	SMILES O=C(O)C(N)CCCC;
	InChI InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9) ; Key:SLXKOJJOQWFEFD-UHFFFAOYSA-N ;
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