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1. 麻酔後ケア病棟における合併症発生の概要 overview of complications occurring in the post anesthesia care unit
2. パーキンソン病の薬理学的治療 pharmacologic treatment of parkinson disease
3. 悪性腫瘍関連胃不全麻痺：病態生理およびマネージメント malignancy associated gastroparesis pathophysiology and management
4. 制吐剤の特性 characteristics of antiemetic drugs
5. 薬剤誘発性の弁膜症 valvular heart disease induced by drugs

English Journal

Randomised clinical trial: prucalopride, a colonic pro-motility agent, reduces the duration of post-operative ileus after elective gastrointestinal surgery.

Gong J1, Xie Z1, Zhang T1, Gu L1, Yao W1, Guo Z1, Li Y1, Lu N1, Zhu W1, Li N1, Li J1.
Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2016 Apr;43(7):778-89. doi: 10.1111/apt.13557. Epub 2016 Feb 15.
BACKGROUND: Previous studies have shown that recovery of colonic transit is a major determinant of post-operative ileus and clinical recovery after gastrointestinal surgery. Prucalopride is a highly selective 5-hydroxytryptamine receptor-4 agonist with colonic pro-motility effects.AIM: To evaluate t
PMID 26880227

Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Bennet H1, Mollet IG2, Balhuizen A3, Medina A3, Nagorny C4, Bagge A4, Fadista J5, Ottosson-Laakso E5, Vikman P5, Dekker-Nitert M5,6, Eliasson L2, Wierup N7, Artner I8, Fex M3.
Diabetologia.Diabetologia.2016 Apr;59(4):744-54. doi: 10.1007/s00125-015-3847-6. Epub 2016 Jan 6.
AIMS/HYPOTHESIS: The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5
PMID 26733006

Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures.

Waller JA1, Chen F2, Sánchez C3.
Neuropharmacology.Neuropharmacology.2016 Apr;103:143-54. doi: 10.1016/j.neuropharm.2015.12.012. Epub 2015 Dec 15.
Cognitive dysfunction is prevalent in patients with major depressive disorder (MDD), and cognitive impairments can persist after relief of depressive symptoms. The multimodal-acting antidepressant vortioxetine is an antagonist at 5-HT3, 5-HT7, and 5-HT1D receptors, a partial agonist at 5-HT1B recept
PMID 26702943