WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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1. セロトニンモジュレータ：薬理学、投与、および副作用 serotonin modulators pharmacology administration and side effects
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3. 麻酔後ケア病棟における合併症発生の概要 overview of complications occurring in the post anesthesia care unit
4. 成人における片頭痛の病態生理、臨床症状、および診断 pathophysiology clinical manifestations and diagnosis of migraine in adults
5. 制吐剤の特性 characteristics of antiemetic drugs

Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.

Kucwaj-Brysz K1, Warszycki D2, Podlewska S3, Witek J2, Witek K1, González Izquierdo A4, Satała G2, Loza MI4, Lubelska A1, Latacz G1, Bojarski AJ2, Castro M4, Kieć-Kononowicz K1, Handzlik J5.
European journal of medicinal chemistry.Eur J Med Chem.2016 Apr 13;112:258-69. doi: 10.1016/j.ejmech.2016.02.024. Epub 2016 Feb 9.
A series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins with 2-hydroxypropyl linker (2-15) was synthesized and evaluated on their affinity towards serotonin 5-HT7 receptor (5-HT7R) in comparison to other closely related GPCRs: serotonin 5-HT1A, and dopamine D2 receptors. The functiona
PMID 26900658

Aging-induced changes in brain regional serotonin receptor binding: Effect of Carnosine.

Banerjee S1, Poddar MK2.
Neuroscience.Neuroscience.2016 Apr 5;319:79-91. doi: 10.1016/j.neuroscience.2016.01.032. Epub 2016 Jan 22.
Monoamine neurotransmitter, serotonin (5-HT) has its own specific receptors in both pre- and post-synapse. In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied. The results showed that during aging (
PMID 26808776

Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice.

Ene HM1, Kara NZ1, Barak N1, Reshef Ben-Mordechai T1, Einat H1.
Acta neuropsychiatrica.Acta Neuropsychiatr.2016 Apr;28(2):85-91. doi: 10.1017/neu.2015.53. Epub 2015 Sep 11.
OBJECTIVE: A number of atypical antipsychotic drugs were demonstrated to have anxiolytic effects in patients and in animal models. These effects were mostly suggested to be the consequence of the drugs' affinity to the serotonin system and its receptors. Asenapine is a relatively new atypical antips
PMID 26357996

5-Hydroxytryptamine and Its Receptors in Systemic Vascular Walls (Recent Advances in 5-Hydroxytryptamine (5-HT) Receptor Research : How Many Pathophysiological Roles Does 5-HT Play via Its Multiple Receptor Subtypes?)

5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases (Recent Advances in 5-Hydroxytryptamine (5-HT) Receptor Research : How Many Pathophysiological Roles Does 5-HT Play via Its Multiple Receptor Subtypes?)