5-hydroxytryptamine receptor

出典: meddic

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  • Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.
  • Kucwaj-Brysz K1, Warszycki D2, Podlewska S3, Witek J2, Witek K1, González Izquierdo A4, Satała G2, Loza MI4, Lubelska A1, Latacz G1, Bojarski AJ2, Castro M4, Kieć-Kononowicz K1, Handzlik J5.
  • European journal of medicinal chemistry.Eur J Med Chem.2016 Apr 13;112:258-69. doi: 10.1016/j.ejmech.2016.02.024. Epub 2016 Feb 9.
  • A series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins with 2-hydroxypropyl linker (2-15) was synthesized and evaluated on their affinity towards serotonin 5-HT7 receptor (5-HT7R) in comparison to other closely related GPCRs: serotonin 5-HT1A, and dopamine D2 receptors. The functiona
  • PMID 26900658
  • Aging-induced changes in brain regional serotonin receptor binding: Effect of Carnosine.
  • Banerjee S1, Poddar MK2.
  • Neuroscience.Neuroscience.2016 Apr 5;319:79-91. doi: 10.1016/j.neuroscience.2016.01.032. Epub 2016 Jan 22.
  • Monoamine neurotransmitter, serotonin (5-HT) has its own specific receptors in both pre- and post-synapse. In the present study the role of carnosine on aging-induced changes of [(3)H]-5-HT receptor binding in different brain regions in a rat model was studied. The results showed that during aging (
  • PMID 26808776
  • Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice.
  • Ene HM1, Kara NZ1, Barak N1, Reshef Ben-Mordechai T1, Einat H1.
  • Acta neuropsychiatrica.Acta Neuropsychiatr.2016 Apr;28(2):85-91. doi: 10.1017/neu.2015.53. Epub 2015 Sep 11.
  • OBJECTIVE: A number of atypical antipsychotic drugs were demonstrated to have anxiolytic effects in patients and in animal models. These effects were mostly suggested to be the consequence of the drugs' affinity to the serotonin system and its receptors. Asenapine is a relatively new atypical antips
  • PMID 26357996


  • 5-Hydroxytryptamine and Its Receptors in Systemic Vascular Walls (Recent Advances in 5-Hydroxytryptamine (5-HT) Receptor Research : How Many Pathophysiological Roles Does 5-HT Play via Its Multiple Receptor Subtypes?)
  • Machida Takuji,Iizuka Kenji,Hirafuji Masahiko
  • Biological & pharmaceutical bulletin 36(9), 1416-1419, 2013-09
  • NAID 40019760071
  • 5-Hydroxytryptamine Receptors as Targets for Drug Therapies of Vascular-Related Diseases (Recent Advances in 5-Hydroxytryptamine (5-HT) Receptor Research : How Many Pathophysiological Roles Does 5-HT Play via Its Multiple Receptor Subtypes?)
  • Gamoh Shuji,Hisa Hiroaki,Yamamoto Ryuichi
  • Biological & pharmaceutical bulletin 36(9), 1410-1415, 2013-09
  • NAID 40019760059


Unique amongst the GPCRs, RNA editing produces 5-HT 2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to G q/11 and also pharmacology [12,138]. Most 5-HT receptors (except 5-ht 1e , ...
The 5-hydroxytryptamine 4 Receptor Agonist In spontaneously contracting ES guts as mentioned above, where enteric neural networks were not identified, a 5-HT 4 R-agonist, MOS added during EB formation succeeded ...


Available structuresAvailable structuresAnti-5-Hydroxytryptamine_Receptor_3B 4iar » 5-hydroxytryptamine receptor 1B Hydroxytryptamine Receptor 2C, Fig. 24iaq » 5-hydroxytryptamine receptor 1B



  [★] 受容体

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「a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response」

PrepTutorEJDIC   license prepejdic

「=sense organ / 受信装置」