5-azacytidine

出典: meddic

5-アザシチジン

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/16 10:12:33」(JST)

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英文文献

  • Hypermethylation of Wnt antagonist gene promoters and activation of Wnt pathway in myelodysplastic marrow cells.
  • Masala E, Valencia A, Buchi F, Nosi D, Spinelli E, Gozzini A, Sassolini F, Sanna A, Zecchi S, Bosi A, Santini V.SourceUF Ematologia, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy.
  • Leukemia research.Leuk Res.2012 Oct;36(10):1290-5. Epub 2012 Jun 27.
  • We observed aberrant gene methylation of Wnt antagonists: sFRP1, sFRP2, sFRP4, sFRP5 and DKK1 in marrow cells of 55 MDS cases. Methylation of Wnt antagonist genes was associated with activation of the Wnt signaling pathway, consistent with the up-regulation of the Wnt downstream genes TCF1 and LEF1.
  • PMID 22742816
  • Deferasirox treatment for myelodysplastic syndromes: "real-life" efficacy and safety in a single-institution patient population.
  • Breccia M, Finsinger P, Loglisci G, Federico V, Santopietro M, Colafigli G, Petrucci L, Salaroli A, Serrao A, Latagliata R, Alimena G.SourceDepartment of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy, breccia@bce.uniroma1.it.
  • Annals of hematology.Ann Hematol.2012 Sep;91(9):1345-9. Epub 2012 May 9.
  • We here describe a single-institution experience on 40 patients with myelodysplastic syndromes (MDS) consecutively treated with deferasirox at the dose of 10-30 mg/kg/day according to Consensus Guidelines on Iron Chelation Therapy, outside of clinical trials. Serum ferritin (SF) was measured monthl
  • PMID 22569854

和文文献

  • Mechanisms of neurotoxicity induced in the developing brain of mice and rats by DNA-damaging chemicals
  • DOI Kunio
  • Journal of toxicological sciences 36(6), 695-712, 2011-12-01
  • … This paper reviews the mechanisms of neurotoxicity induced in the developing brain of mice and rats by six chemicals (ethylnitrosourea, hydroxyurea, 5-azacytidine, cytosine arabinoside, 6-mercaptopurine and etoposide), which cause DNA damage in different ways, especially from the viewpoints of apoptosis and cell cycle arrest in neural progenitor cells.  …
  • NAID 10030036432
  • Synthesis of O[2]- and N[3]-(2-phosphonomethoxy)ethyl derivatives of 6-phenyl- and 6-pyridinyl-5-azacytosine
  • Otmar Miroslav,Dracinsky Martin,Krecmerova Marcela [他]
  • Heterocycles 83(4), 797-813, 2011-04-01
  • NAID 40018733653

関連リンク

細胞毒性が低く、高い細胞透過性を持ち、細胞増殖を抑制します。5-Azacytidineや5- Aza-2'-deoxycytidineなど、濃度依存的にゲノムDNAの脱メチル化を引き起こす、 シチジン類縁体のDNAメチル化競合阻害剤とは異なり、DNAメチルトランスフェラーゼ1 の ...

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5-アザシトシン 5-azacytosine
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