WordNet

a drug that neutralizes or counteracts the effects of another drug
a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
the 8th letter of the Roman alphabet (同)h

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対立する人,敵対者,競争相手(opponent)
hydrogenの化学記号
鉛筆の硬度 / 《俗》heroin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/19 17:45:38」(JST)

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A serotonin antagonist is a drug used to inhibit the action at serotonin (5-HT) receptors.

Types[edit]

5-HT_2A antagonists[edit]

Antagonists of the 5-HT_2A receptor are sometimes used as atypical antipsychotics (contrast with typical antipsychotics, which are purely dopamine antagonists). They include:

Clozapine blocks 5-HT_2A, 5-HT_2C and D₄ receptors.
Cyproheptadine blocks 5-HT_2A, HI and is a mild anticholinergic.
Ketanserin blocks 5-HT_2A, 5-HT_2C and Alpha 1 (A1) adrenoreceptors.
Methysergide is a 5-HT_2A antagonist and nonselective 5-HT₁ receptor blocker. It causes retroperitoneal fibrosis and mediastinal fibrosis^{[citation needed]}.
Quetiapine blocks 5-HT_2A, 5-HT_1A, dopamine receptors D₁ and D₂, histamine receptor H1, and A1 adrenoreceptors.

5-HT₃ antagonists[edit]

Another subclass consists of drugs selectively acting at the 5-HT₃ receptors, and thus are known as 5-HT₃ antagonists. They are efficacious in treating chemotherapy-induced emesis.^[1] They include:

Dolasetron
Granisetron
Ondansetron
Palonosetron
Tropisetron

Other 5-HT₃ antagonists are used for the treatment of irritable bowel syndrome:

Alosetron
Cilansetron

Others[edit]

Pizotifen is a 5-HT_2C antagonist, H1 blocker and anticholinergic useful in migraine prophylaxis^{[citation needed]}.
Feverfew is a herb traditionally used for migraines.

References[edit]

^ Lindley, C.; Blower, P. (2000). "Oral serotonin type 3-receptor antagonists for prevention of chemotherapy-induced emesis". American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 57 (18): 1685–1697. PMID 11006796. edit

External links[edit]

Serotonin Antagonists at the US National Library of Medicine Medical Subject Headings (MeSH)
MeSH list of agents 82012702

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. クリオピリン関連周期性発熱症候群および関連疾患 cryopyrin associated periodic syndromes and related disorders
2. 周期性発熱症候群およびその他の自己炎症性疾患：概要 periodic fever syndromes and other autoinflammatory diseases an overview
3. Prevention and treatment of chemotherapy-induced nausea and vomiting in adults
4. 制吐剤の特性 characteristics of antiemetic drugs
5. 化学療法誘発性悪心および嘔吐の病態生理および予測 pathophysiology and prediction of chemotherapy induced nausea and vomiting

English Journal

Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson's disease treated with l-DOPA.

Dominguez-Meijide A, Villar-Cheda B, Garrido-Gil P, Sierrra-Paredes G, Guerra MJ, Labandeira-Garcia JL.SourceLaboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain; Networking Research Center on Neurodegenerative Diseases (CIBERNED), Spain.
Neuropharmacology.Neuropharmacology.2014 Jan;76 Pt A:156-68. doi: 10.1016/j.neuropharm.2013.07.016. Epub 2013 Aug 20.
Beneficial effects of angiotensin type-1 receptor (AT1) inhibition have been observed in a number of brain processes mediated by oxidative stress and neuroinflammation, including Parkinson's disease. However, important counterregulatory interactions between dopamine and angiotensin systems have rece
PMID 23973568

Influence of aripiprazole pretreatment on the reinforcing effects of methamphetamine in humans.

Stoops WW, Bennett JA, Lile JA, Sevak RJ, Rush CR.SourceUniversity of Kentucky College of Medicine, Department of Behavioral Science, 140 Medical Behavioral Science Building, Lexington, KY 40536-0086, United States; University of Kentucky College of Arts and Sciences, Department of Psychology, 110 Kastle Hall, Lexington, KY 40506-0044, United States. Electronic address: william.stoops@uky.edu.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2013 Dec;47:111-7. doi: 10.1016/j.pnpbp.2013.08.007. Epub 2013 Aug 28.
Methamphetamine use disorders remain a significant public health concern. Methamphetamine produces its behavioral effects by facilitating release of monoamines like dopamine (DA) and serotonin (5-HT). Results from animal studies show that acute pretreatment with DA and 5-HT antagonists attenuates th
PMID 23994622

Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists.

Brudeli B, Andressen KW, Moltzau LR, Nilsen NO, Levy FO, Klaveness J.SourceDrug Discovery Laboratory AS, Oslo Innovation Center, N-0349 Oslo, Norway; Department of Medicinal Chemistry, School of Pharmacy, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2013 Nov 15;21(22):7134-45. doi: 10.1016/j.bmc.2013.09.004. Epub 2013 Sep 11.
Serotonin (5-hydroxytryptamine, 5-HT) is an important signaling molecule in the central nervous system (CNS) and in non-neuronal tissues and organs. Serotonin mediates a positive chronotropic and inotropic response through 5-HT4 receptors in the atrium and ventricle of the heart. Recent investigatio
PMID 24113240

Japanese Journal

Effect of Selective Serotonin Reuptake Inhibitors via 5-HT_<1A> Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model

INDEN Masatoshi,ABE Mari,MINAMINO Hideaki,TAKATA Kazuyuki,YOSHIMOTO Kanji,TOOYAMA Ikuo,KITAMURA Yoshihisa
Journal of pharmacological sciences 119(1), 10-19, 2012-05-20
… These effects of fluoxetine were abolished by pre-treatment with WAY 100135, a 5-HT<SUB>1A</SUB> … antagonist. …
NAID 10030760133