5-HT4 receptor

出典: meddic


5-HT4 serotonin receptor

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/03/17 11:59:25」(JST)

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  • Discovery of TD-8954, a clinical stage 5-HT4 receptor agonist with gastrointestinal prokinetic properties.
  • McKinnell RM, Armstrong SR, Beattie DT, Fatheree PR, Long DD, Marquess DG, Shaw JP, Vickery RG.SourceTheravance, Inc., 901 Gateway Blvd, South San Francisco, CA 94080, United States. Electronic address: mmckinnell@theravance.com.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2013 Jul 15;23(14):4210-5. doi: 10.1016/j.bmcl.2013.05.018. Epub 2013 May 16.
  • The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the benzimidazole ring led to a series of agonists with subnanomolar binding affinity and moderate-to-high intrinsic activity relative to that o
  • PMID 23756062
  • Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.
  • Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B.SourceCenter for Human Genetics, Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven, Leuven, Belgium ina.tesseur@med.kuleuven.be
  • Neurobiology of aging.Neurobiol Aging.2013 Jul;34(7):1779-89. doi: 10.1016/j.neurobiolaging.2013.01.020. Epub 2013 Mar 6.
  • Lowering the production and accumulation of Aβ has been explored as treatment for Alzheimer's disease (AD), because Aβ is postulated to play an important role in the pathogenesis of AD. 5-HT4 receptors are an interesting drug target in this regard, as their activation might stimulate α-secretase
  • PMID 23474291
  • Ozone exposure alters serotonin and serotonin receptor expression in the developing lung.
  • Murphy SR, Schelegle ES, Miller LA, Hyde DM, Van Winkle LS.Source* Center for Health and the Environment.
  • Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2013 Jul;134(1):168-79. doi: 10.1093/toxsci/kft090. Epub 2013 Apr 9.
  • Ozone, a pervasive environmental pollutant, adversely affects functional lung growth in children. Animal studies demonstrate that altered lung development is associated with modified signaling within the airway epithelial mesenchymal trophic unit, including mediators that can change nerve growth. We
  • PMID 23570994


  • A protein tyrosine kinase receptor, c-RET signaling pathway contributes to the enteric neurogenesis induced by a 5-HT₄ receptor agonist at an anastomosis after transection of the gut in rodents
  • Goto Kei,Kawahara Isao,Kuniyasu Hiroki [他]
  • The journal of physiological sciences 65(4), 377-383, 2015-07
  • NAID 40020509938
  • 炎症性腸疾患モデル動物における温度感受性受容体TRPV1とセロトニンシグナリングの変化
  • 松本 健次郎
  • 薬学雑誌. 乙号 134(11), 1165-1170, 2014
  • … Hypersensitivity of afferent fibers occurs during inflammation, and therefore to gain insight into the alteration of receptors and channels, we examined receptors such as 5-HT receptors and transient receptor potential vanilloid type 1 (TRPV1), which are expressed in primary afferent neurons. …
  • NAID 130004712972
  • 排便と健康
  • 浦尾 正彦
  • 順天堂醫事雑誌 60(1), 16-24, 2014
  • 便秘とは,排便の頻度が週2回以下で,便が硬く,排便困難,残便感がある状態といわれている.実際には放置されていたり自己流の対処をされていることが多い.が,便秘患者では労働生産性が障害されたり,肛門疾患や結腸癌などの様々なリスクも増加することが知られており,しっかり取り組むべき疾患である.慢性便秘は,症候性,薬剤性,器質性,機能性便秘などに分類される.症候性便秘は神経疾患,内分泌疾患の症状の一部として …
  • NAID 130004684311


5-hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to ...






5-HT4 receptor



5-HT4 receptor



5-HT4 receptor



5-HT4 receptor



WordNet   license wordnet

「the 8th letter of the Roman alphabet」

PrepTutorEJDIC   license prepejdic


PrepTutorEJDIC   license prepejdic

「鉛筆の硬度 / 《俗》heroin」


  [★] 受容体

WordNet   license wordnet

「a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response」

PrepTutorEJDIC   license prepejdic

「=sense organ / 受信装置」