WordNet

incapable of harmonious association
characterized by antagonism or antipathy; "slaves antagonistic to their masters"; "antipathetic factions within the party" (同)antipathetic, antipathetical
indicating opposition or resistance (同)counter
used especially of drugs or muscles that counteract or neutralize each others effect (同)incompatible
arousing animosity or hostility; "his antagonistic brusqueness"; "Europe was antagonistic to the Unites States"
a drug that neutralizes or counteracts the effects of another drug
a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
the 8th letter of the Roman alphabet (同)h
a drug that prevents or alleviates nausea and vomiting (同)antiemetic_drug

PrepTutorEJDIC

敵対する,反目する;(…に)敵対している《+『to』+『名』》
対立する人,敵対者,競争相手(opponent)
hydrogenの化学記号
鉛筆の硬度 / 《俗》heroin

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1. 成人の化学療法誘発性悪心・嘔吐の予防と治療prevention and treatment of chemotherapy induced nausea and vomiting in adults [show details]
… daily dose of a 5-HT3 antagonist (eg, ondansetron 8 to 16 mg, dolasetron 100 mg, or granisetron 1 to 2 mg), as needed. Despite the use of appropriate antiemetic prophylaxis, many patients experience …
2. 制吐剤の特性characteristics of antiemetic drugs [show details]
… metoclopramide) was formerly the antiemetic regimen of choice with highly emetogenic chemotherapy . However, it has largely been replaced by the 5-HT3 receptor antagonists due to their superior efficacy …
3. 術後に生じる悪心と嘔吐postoperative nausea and vomiting [show details]
… with propofol for very-high-risk patients. Antiemetics – We administer the following antiemetics: Dexamethasone 0.25 mg/kg IV, maximum 4 mg Ondansetron 0.1 mg/kg IV, maximum 4 mg Postoperative pain …
4. 放射線療法による悪心および嘔吐：予防と治療radiotherapy induced nausea and vomiting prophylaxis and treatment [show details]
… placebo . Similarly, 5-HT3 receptor antagonists provided significantly better protection against RINV caused by total body irradiation or hemibody irradiation than conventional antiemetics or placebo . Separate …
5. 成人における片頭痛の急性期治療acute treatment of migraine in adults [show details]
… an antiemetic in these studies is uncertain, since the antiemetic metoclopramide is known to be effective for migraine when used alone . However, in several studies DHE combined with an antiemetic was… migraine using ondansetron or granisetron has not been rigorously evaluated, although there are reports describing their use . However, both ondansetron and granisetron have been associated…

English Journal

Identification of Glycyrrhiza as the rikkunshito constituent with the highest antagonistic potential on heterologously expressed 5-HT3A receptors due to the action of flavonoids.

Herbrechter R1, Ziemba PM1, Hoffmann KM1, Hatt H1, Werner M1, Gisselmann G1.
Frontiers in pharmacology.Front Pharmacol.2015 Jul 3;6:130. doi: 10.3389/fphar.2015.00130. eCollection 2015.
The traditional Japanese phytomedicine rikkunshito is traditionally used for the treatment of gastrointestinal motility disorders, cachexia and nausea. These effects indicate 5-HT3 receptor antagonism, due to the involvement of these receptors in such pathophysiological processes. E.g., setrons, spe
PMID 26191003

Effects of mosapride citrate, a 5-HT4-receptor agonist, on gastric distension-induced visceromotor response in conscious rats.

Seto Y1, Yoshida N, Kaneko H.
Journal of pharmacological sciences.J Pharmacol Sci.2011;116(1):47-53. Epub 2011 Apr 27.
Mosapride citrate (mosapride), a prokinetic agent with 5-HT(4)-receptor agonistic activity, is known to enhance gastric emptying and alleviate symptoms in patients with functional dyspepsia (FD). As hyperalgesia and delayed gastric emptying play an important role in the pathogenesis of FD, we used i
PMID 21521930

Arylalkylamine-, beta-carboline-, quinolizine- and azecine-derived compounds and their in vitro interaction with the ionotropic 5-HT3 receptor: search for new lead structures.

Enzensperger C1, Lehmann J, von Schroetter K, Riyazi A, Verspohl EJ.
Arzneimittel-Forschung.Arzneimittelforschung.2010;60(9):544-52. doi: 10.1055/s-0031-1296323.
Specific serotonin receptor agonists and antagonists are marketed with respect to various diseases, most prominently severe emesis. To identify new chemical classes with affinity for the serotonin 5-HT3 channel, several compounds were synthesized which can be structurally classified as arylalkylamin
PMID 21117497

Japanese Journal

Synthesis and Structure-Activity Relationships of 4-Amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide Derivatives, Novel and Potent Serotonin 5-HT_3 and Dopamine D_2 Receptors Dual Antagonist