5-HT3 agonist

出典: meddic

5-HT agonist5-HT1 agonist5-HT2 agonistserotonergic agonistserotonin agonistserotonin receptor agonist

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  • The complex role of serotonin and 5-HT receptors in chronic pain.
  • Bardin L.SourceDivision of Neurobiology 2, Centre de Recherche Pierre Fabre, Castres, France.
  • Behavioural pharmacology.Behav Pharmacol.2011 Jul 29. [Epub ahead of print]
  • Serotonin [5-hydroxytryptamine (5-HT)] in the central nervous system and in the periphery has long been considered to have an important role in the control of pain, for example, through descending inhibition. In recent years, considerable research efforts have focused on the role played by 5-HT on a
  • PMID 21808193
  • Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
  • Bang-Andersen B, Ruhland T, Jorgensen M, Smith G, Frederiksen K, Jensen KG, Zhong H, Nielsen SM, Hogg S, Mork A, Stensbol TB.SourceNeuroscience Drug Discovery Denmark, H. Lundbeck A/S , 9 Ottiliavej, DK-2500 Copenhagen-Valby, Denmark. ban@lundbeck.com
  • Journal of medicinal chemistry.J Med Chem.2011 May 12;54(9):3206-21. Epub 2011 Apr 12.
  • The synthesis and structure-activity relationship of a novel series of compounds with combined effects on 5-HT(3A) and 5-HT(1A) receptors and on the serotonin (5-HT) transporter (SERT) are described. Compound 5m (Lu AA21004) was the lead compound, displaying high affinity for recombinant human 5-HT(
  • PMID 21486038


  • Effects of Mosapride Citrate, a 5-HT4–Receptor Agonist, on Gastric Distension–Induced Visceromotor Response in Conscious Rats
  • Seto Yasuhiro,Yoshida Naoyuki,Kaneko Hiroshi
  • Journal of Pharmacological Sciences 116(1), 47-53, 2011
  • … Mosapride citrate (mosapride), a prokinetic agent with 5-HT4–receptor agonistic activity, is known to enhance gastric emptying and alleviate symptoms in patients with functional dyspepsia (FD). … Additionally, a major metabolite M1 of mosapride, which possesses 5-HT3–receptor antagonistic activity, inhibited gastric distension–induced VMR. …
  • NAID 130000663527
  • Possible Involvement of β1 Receptors in Various Emetogen-Induced Increases in Salivary Amylase Activity in Rats
  • Fukui Hideo,Suyama Yoshimi,Iwachido Takako,Miwa Eri
  • Journal of Pharmacological Sciences advpub(0), 1012130486, 2010
  • … We investigated the inhibitory effects of β1- or β2-adrenoceptor (AR) antagonists on salivary amylase secretion produced by various emetic agents, such as cisplatin, apomorphine, and lithium chloride (LiCl), or the non-emetic agent β1/2-AR agonist isoprenaline in rats. …
  • NAID 130000439925


The 5-HT3 antagonists are a class of medications that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain. With the notable exception ...



リンク元5-HT agonist」「5-HT3刺激薬」「5-HT3アゴニスト」「serotonin agonist」「serotonergic agonist

5-HT agonist」


5-HT1 agonist5-HT2 agonist5-HT3 agonistserotonergic agentserotonergic agonistserotonin agonistserotonin receptor agonist



5-HT3 agonist



5-HT3 agonist

serotonin agonist」


5-HT agonist5-HT1 agonist5-HT2 agonist5-HT3 agonistserotonergic agentserotonergic agonistserotonin receptor agonist

serotonergic agonist」


5-HT agonist5-HT1 agonist5-HT2 agonist5-HT3 agonistserotonergic agentserotonin agonistserotonin receptor agonist


  [★] 作動薬

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「(biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction」

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「a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"」

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「someone involved in a contest or battle (as in an agon)」



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「the 8th letter of the Roman alphabet」

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「鉛筆の硬度 / 《俗》heroin」