出典: meddic


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  • Primary resistance phenomena to oncolytic measles vaccine viruses.
  • Noll M, Berchtold S, Lampe J, Malek NP, Bitzer M, Lauer UM.SourceDepartment of Internal Medicine I, University Hospital Tübingen, D-72076 Tübingen, Germany.
  • International journal of oncology.Int J Oncol.2013 Apr 23. doi: 10.3892/ijo.2013.1914. [Epub ahead of print]
  • Measles vaccine virus (MeV) has been shown to possess profound oncolytic capabilities. However, tumor cell resistance to MeV may endanger broad clinical success. Here, this hypothesis is underlined by our analysis of the NCI-60 tumor cell panel infected with a suicide gene-armed MeV vector (MeV-SCD)
  • PMID 23612727
  • In Vitro and In Vivo Effect of 5-FC Combined Gene Therapy with TNF-α and CD Suicide Gene on Human Laryngeal Carcinoma Cell Line Hep-2.
  • Chai LP, Wang ZF, Liang WY, Chen L, Chen D, Wang AX, Zhang ZQ.SourceDepartment of Otolaryngology, First Affiliated Hospital and Otolaryngology Institute, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. China.
  • PloS one.PLoS One.2013 Apr 11;8(4):e61136. doi: 10.1371/journal.pone.0061136. Print 2013.
  • This study was aimed to investigate the effect of combined cancer gene therapy with exogenous tumor necrosis factor-alpha (TNF-α) and cytosine deaminase (CD) suicide gene on laryngeal carcinoma cell line Hep-2 in vitro and in vivo. Transfection of the recombinant eukaryotic vectors of pcDNA3.1 (+)
  • PMID 23593411
  • A novel armed oncolytic measles vaccine virus for the treatment of cholangiocarcinoma.
  • Lange S, Lampe J, Bossow S, Zimmermann M, Neubert W, Bitzer M, Lauer UM.SourceMedical University Hospital Tübingen, Department of Gastroenterology & Hepatology, Tübingen, Germany ; mail@sebastianlange.net.
  • Human gene therapy.Hum Gene Ther.2013 Apr 4. [Epub ahead of print]
  • Cholangiocarcinoma is curable only in early stages by complete surgical resection. Thus, in advanced disease stages in which a complete removal of the tumor mass is no longer possible and palliative chemotherapy only achieves modest success, therapeutics employing new methods of action are desperate
  • PMID 23550539


  • Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma
  • Kosaka H,Ichikawa T,Kurozumi K,Kambara H,Inoue S,Maruo T,Nakamura K,Hamada H,Date I
  • Cancer Gene Therapy 19(8), 572-578, 2012-08-00
  • … We evaluated a new therapeutic strategy for malignant glioma, which combines intratumoral inoculation of mesenchymal stem cells (MSCs) expressing cytosine deaminase gene with 5-fluorocytosine (5-FC) administration. … Co-culture of 9L glioma cells with MSC-CD in a medium containing 5-FC resulted in a remarkable reduction in 9L cell viability. …
  • NAID 120005232495
  • W1-5  Fc γ RIIB欠損B6マウスへのYaa遺伝子導入によるRAからSLEへの表現型移行
  • 河野 晋也,天野 浩文,金子 俊之,佐藤 綾,林 青順,広瀬 幸子,髙崎 芳成
  • 日本臨床免疫学会会誌 35(4), 301a-301a, 2012
  • … (背景)FcγRIIBは,B細胞の活性化を負にフィードバックする重要な免疫制御分子である.このFcγRIIBを野生型C57BL/6(B6)マウスで欠損したB6.FcγRIIB−/−マウスでは,リウマトイド因子(RF)の出現と関節破壊を伴う関節リウマチ(RA)の病態を呈した(Arthritis Rheum 2011).我々はこのマウスにToll様受容体(TLR)7の重複であるYaa遺伝子を導入することで病態の変化が生じるかを確認 …
  • NAID 130003363993
  • Effects of levocarnitine in hemodialysis patients
  • 武内 操,清原 実千代,町田 博文,武内 秀之
  • 日本透析医学会雑誌 45(10), 955-963, 2012
  • … The average levels of total carnitine (TC) and free carnitine (FC) within one year after the introduction of dialysis were 57.9±18.2 and 38.8±13.6 μmol/L, respectively. … At one year, however, these levels significantly decreased to 39.3±18.6 (TC) and 25.0±12.5 (FC) μmol/L (p<0.01), respectively, and continued to decrease in accordance with the duration of hemodialysis. …
  • NAID 130003298105


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5-フルシトシン 5-flucytosine 5-FCアンコボン ancobon,5-フルオロシトシン 5-fluorocytosine


  [★] フェニルアラニン phenylalanine

WordNet   license wordnet

「the 6th letter of the Roman alphabet」

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