関: 5,7-DHT

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/31 06:54:03」(JST)

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5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin^[1]^[2] used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect isn't well-understood, but many believe (without clear substantiation) that it selectively kills serotonergic neurons, in a similar way that 6-hydroxydopamine (6-OHDA) is used to kill dopaminergic cells. What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimiprimine (desipramine), which inhibits the norepinephrine transporter.

References[edit]

^ Cairncross, KD; Cox, B; Forster, C; Wren, A (1977). "The ability of local injection of 6-OHDA, 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British Journal of Pharmacology 61 (1): 145P–146P. PMC 1667625. PMID 912193.
^ Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats". Brain Research 1149: 216–22. doi:10.1016/j.brainres.2007.02.052. PMID 17376410.

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English Journal

Effects of serotonergic terminal lesion in the amygdala on conditioned fear and innate fear in rats.

Izumi T, Ohmura Y, Futami Y, Matsuzaki H, Kubo Y, Yoshida T, Yoshioka M.SourceDepartment of Neuropharmacology, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060-8638, Japan. Electronic address: psyizumi@med.hokudai.ac.jp.
European journal of pharmacology.Eur J Pharmacol.2012 Dec 5;696(1-3):89-95. doi: 10.1016/j.ejphar.2012.09.028. Epub 2012 Oct 1.
The amygdala and the medial prefrontal cortex (mPFC) are crucial brain structures for anxiety, and it is speculated that the serotonergic neural system in these structures has an important role in regulating anxiety. In our previous study, we indicated that local injections of selective serotonin re
PMID 23036373

Serotonergic neural links from the dorsal raphe nucleus modulate defensive behaviours organised by the dorsomedial hypothalamus and the elaboration of fear-induced antinociception via locus coeruleus pathways.

Biagioni AF, de Freitas RL, da Silva JA, de Oliveira RC, de Oliveira R, Alves VM, Coimbra NC.SourceLaboratório de Neuroanatomia & Neuropsicobiologia, Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Av. dos Bandeirantes, 3900, Ribeirão Preto (SP), 14049-900, Brasil; Instituto de Neurociências e Comportamento (INeC), Universidade de São Paulo (USP), Av. dos Bandeirantes, 3900, Ribeirão Preto (SP), 14040-901, Brasil; NAP-USP-Neurobiologia das Emoções (NuPNE), Departamento de Farmacologia da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP), Av. dos Bandeirantes, 3900, Ribeirão Preto (SP), 14049-900, Brasil.
Neuropharmacology.Neuropharmacology.2012 Nov 29. pii: S0028-3908(12)00527-8. doi: 10.1016/j.neuropharm.2012.10.024. [Epub ahead of print]
Decrease of γ-aminobutyric acid (GABA)-mediated neurotransmission in the dorsomedial hypothalamus (DMH) evokes instinctive fear-like responses. The aim of the present study was to investigate the involvement of the serotonin (5-HT)- and norepinephrine-mediated pathways of the endogenous pain inhibi
PMID 23201351

Japanese Journal

Involvement of descending monoaminergic systems in antiallodynic effect of goshajinkigan in oxaliplatin-treated mice

Journal of Traditional Medicines 30(4), 183-189, 2013
NAID 130004942434

Property of Regenerating Serotonin Fibers in the Hippocampus of Human Migration Disorders Model

Kansei Engineering International Journal 11, 139-145, 2012
NAID 130002148650

Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice

Journal of pharmacological sciences 115(3), 417-420, 2011-03-20
NAID 10029892967

「5,7-ジヒドロキシトリプタミン」

5,7-Dihydroxytryptamine
	IUPAC name 3-(2-aminoethyl)-1H-indole-5,7-diol
	Other names 5,7-Dihydroxytryptamine
Identifiers
CAS number	31363-74-3
PubChem	35781
ChemSpider	32913
ChEMBL	CHEMBL26726
Jmol-3D images	Image 1
	SMILES Oc1cc2c(c(O)c1)ncc2CCN ;
	InChI InChI=1S/C10H12N2O2/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14/h3-5,12-14H,1-2,11H2 ; Key: LXWHQTNFZDTKBH-UHFFFAOYSA-N InChI=1/C10H12N2O2/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14/h3-5,12-14H,1-2,11H2; Key: LXWHQTNFZDTKBH-UHFFFAOYAC ;
Properties
Molecular formula	C10H12N2O2
Molar mass	192.214
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references