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Differential role of serotonin projections from the dorsal and median raphe nuclei in phencyclidine-induced hyperlocomotion and fos-like immunoreactivity in rats.

Kusljic S, Van Den Buuse M.SourceBehavioural Neuroscience Laboratory, Mental Health Research Institute, University of Melbourne, Parkville, Victoria, Australia; Department of Pharmacology, University of Melbourne, Australia.
Synapse (New York, N.Y.).Synapse.2012 Oct;66(10):885-92. doi: 10.1002/syn.21580. Epub 2012 Jul 17.
Altered brain serotonin activity is implicated in schizophrenia. We have previously shown differential involvement of serotonergic projections from the dorsal or median raphe nucleus in phencyclidine-induced hyperlocomotion in rats, a behavioral model of aspects of schizophrenia. Here we further inv
PMID 22733588

Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT(4), 5-HT(6) and 5-HT(7) receptors.

Godínez-Chaparro B, López-Santillán FJ, Orduña P, Granados-Soto V.SourceDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados (Cinvestav), Sede Sur, México, D.F., Mexico.
Neuroscience.Neuroscience.2012 Jul 13. [Epub ahead of print]
In the present study we determined the role of spinal 5-hydroxytriptamine (5-HT) and 5-HT(4/6/7) receptors in the long-term secondary mechanical allodynia and hyperalgesia induced by formalin in the rat. Formalin produced acute nociceptive behaviors (flinching and licking/lifting) followed by long-t
PMID 22796074

Regeneration of 5-HT fibers in hippocampal heterotopia of methylazoxymethanol-induced micrencephalic rats after neonatal 5,7-DHT injection

NAKAMURA Arata,KADOWAKI Taro,SAKAKIBARA Shin-ichi,YOSHIMOTO Kanji,HIRATA Koichi,UEDA Shuichi
Anatomical science international 85(1), 38-45, 2010-03-01
NAID 10027191167

吉岡充弘,富樫広子,山口拓,松本真知子
日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 125(2), 77-82, 2005-02-01
… 負荷すると，脳内神経回路に機能的異常が生じるとの仮説に基づき，幼若期におけるストレス負荷と脳機能発達との関連性を，臨界期という視点から探索した．また関与する内因性制御因子としてセロトニン（5-HT）に着目し，その調節的役割を考察した．幼若期ストレスとして，生後2週齢および3週齢時ラットに足蹠電撃ショック（FS）を負荷し，成熟後（10-12週齢）の情動表出におよぼす影響を，行動学的応答性を指 …
NAID 10014465469