3-hydroxy-3-methylglutaryl CoA reductase

ヒドロキシメチルグルタリルCoA還元酵素

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system
4. an enzyme that catalyses the biochemical reduction of some specified substance
5. being or containing a hydroxyl group

PrepTutorEJDIC

1. carbonの化学記号
2. cobaltの化学記号

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• 4. がん予防 cancer prevention
• 5. 原発性胆汁性肝硬変における代謝性骨疾患 metabolic bone disease in primary biliary cirrhosis

English Journal

• 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain.

• Zhang DD1, Yu HL1, Ma WW1, Liu QR1, Han J1, Wang H1, Xiao R2.
• Neuroscience.Neuroscience.2015 Aug 6;300:163-73. doi: 10.1016/j.neuroscience.2015.05.022. Epub 2015 May 16.
• Cholesterol metabolism is important for neuronal function in the central nervous system (CNS). The oxysterol 27-hydroxycholesterol (27-OHC) is a cholesterol metabolite that crosses the blood-brain barrier (BBB) and may be a useful substitutive marker for neurodegenerative diseases. However, the effe
• PMID 25987203

• Photocontrol of Elicitor Activity of PIP-1 to Investigate Temporal Factors Involved in Phytoalexin Biosynthesis.

• Kim Y1, Miyashita M1, Miyagawa H1.
• Journal of agricultural and food chemistry.J Agric Food Chem.2015 Jul 1;63(25):5894-901. doi: 10.1021/acs.jafc.5b01910. Epub 2015 Jun 19.
• The peptide elicitor PIP-1 can induce various immune responses in tobacco cells. Previously, we showed that types of responses induced by PIP-1 are different depending on its stimulation periods; short-term stimulation induces weak responses, whereas long-term stimulation leads to strong responses i
• PMID 26047371

• HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer's disease in a three cohorts study.

• Leduc V1, De Beaumont L2, Théroux L2, Dea D2, Aisen P3, Petersen RC4; Alzheimer's Disease Neuroimaging Initiative, Dufour R5, Poirier J6.
• Molecular psychiatry.Mol Psychiatry.2015 Jul;20(7):867-73. doi: 10.1038/mp.2014.81. Epub 2014 Jul 15.
• Several retrospective epidemiological studies report that utilization of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitors called statins at mid-life can reduce the risk of developing sporadic Alzheimer's disease (AD) by as much as 70%. Conversely, the administration of these inhibitors in
• PMID 25023145

Japanese Journal

• γ-Tocotrienol Attenuates Triglyceride through Effect on Lipogenic Gene Expressions in Mouse Hepatocellular Carcinoma Hepa 1-6

• BURDEOS Gregor Carpentero,NAKAGAWA Kiyotaka,WATANABE Akio,KIMURA Fumiko,MIYAZAWA Teruo
• Journal of Nutritional Science and Vitaminology 59(2), 148-151, 2013
• … Vitamin E is the generic name for tocopherol (Toc) and tocotrienol (T3), which have saturated and unsaturated side chains, respectively. … Such differences allow T3 to be different from Toc in terms of their functions. … T3 has been known to attenuate cholesterol (Cho) level by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoAR). …
• NAID 130003368161

• Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice

• Ohsawa Masahiro,Mutoh Junpei,Yamamoto Shohei [他],ONO Hideki,HISA Hiroaki
• Journal of pharmacological sciences 119(1), 102-106, 2012-05-20
• … Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. …
• NAID 10030760520

• Effects of Pitavastatin on Pressure Overload-Induced Heart Failure in Mice

• KAMEDA Yoshihito,HASEGAWA Hiroshi,KUBOTA Akihiko,TADOKORO Hiroyuki,KOBAYASHI Yoshio,KOMURO Issei,TAKANO Hiroyuki
• Circulation journal : official journal of the Japanese Circulation Society 76(5), 1159-1168, 2012-04-25
• … Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins), which are widely used to lower plasma cholesterol levels, have been reported to have various pleiotropic effects such as protective effect of endothelial cells, angiogenic effect, antioxidant effect and anti-inflammatory effect. …
• NAID 10030132534

Related Links

• HMG-CoA reductase - Wikipedia, the free encyclopedia

HMG-CoA reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGCR) is the rate-controlling enzyme (EC 1.1.1.88) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. Normally in ...

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★リンクテーブル★

リンク元	「ヒドロキシメチルグルタリルCoA還元酵素」
拡張検索	「3-hydroxy-3-methylglutaryl-CoA reductase」
関連記事	「C」「reductase」「hydroxy」「CoA」「COA」

「ヒドロキシメチルグルタリルCoA還元酵素」

　　[★]

英

hydroxymethylglutaryl-CoA reductase

同

ヒドロキシメチルグルタリルCoAレダクターゼ、HMG-CoA還元酵素 HMG-CoA reductase

3-ヒドロキシ-3-メチルグルタリルCoA還元酵素 3-hydroxy-3-methylglutaryl-CoA reductase 3-hydroxy-3-methylglutaryl CoA reductase

関

「3-hydroxy-3-methylglutaryl-CoA reductase」

　　[★] ヒドロキシメチルグルタリルCoA還元酵素

同

HMGCoA

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「reductase」

　　[★]

• n.

(酵素)還元酵素、レダクターゼ、リダクターゼ

関

dehydrogenase、oxidase、oxidoreductase、reducing enzyme

　

「hydroxy」

　　[★]

ヒドロキシ、ハイドロキシ、水酸化

関

hydroxylation

　

「CoA」

　　[★]

• 大動脈縮窄症 coactation of the aorta
• 補酵素A coenzyme A

「COA」

　　[★] 補酵素A coenzyme A CoA