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1. 若年成人における急性骨髄性白血病に対する導入療法induction therapy for acute myeloid leukemia in younger adults [show details]
… survival: Age >15 years (11 versus 139 months) Ph+ leukemias (8 versus 139 months for Ph-negative disease), but few of these patients received TKI therapy for BCR/ABL. AML-type induction (11 versus 139… differential; Chemistries with electrolytes, glucose, renal function tests, calcium, phosphorus, uric acid, liver function tests, albumin, total protein, and lactate dehydrogenase (LDH) Urine analysis; Coagulation …
2. 急性骨髄性白血病：高齢患者への治療と転帰acute myeloid leukemia treatment and outcomes in older adults [show details]
… APL responds equally well across the age spectrum to all-trans retinoic acid (ATRA) plus arsenic trioxide.… 15 mg/m² IV over four hours every eight hours for three consecutive days,… to as "7+3" therapy. Additional details of 7+3 therapy, daunorubicin dose selection, and consideration of a third agent are provided below and separately. An acceptable alternative to 7+3 therapy…
3. アントラサイクリン系以外の抗がん剤の心毒性cardiotoxicity of non anthracycline cancer chemotherapy agents [show details]
… retinoic acid (ATRA) is used to treat acute promyelocytic leukemia. Approximately 10 to 15 percent of patients develop the differentiation syndrome (previously called the “retinoic acid syndrome”),… left ventricular dysfunction has been seen in up to 11 percent of treated patients: In a phase II trial in…
4. 出血性消化性潰瘍の治療の概要overview of the treatment of bleeding peptic ulcers [show details]
… achieve adequate acid suppression more rapidly than standard doses (eg, omeprazole 20 mg daily), which may take several days to achieve adequate acid suppression .… addition, rebleeding rates were lower (13 versus 18 percent). However, 30-day mortality did not improve (11 percent for both groups), though there was a trend toward decreased mortality after adjusting for potential … have endoscopic signs of active bleeding (6 versus 15 percent) or to require endoscopic hemostatic therapy (19 versus 28 percent).…
5. 癌患者の出血性膀胱炎hemorrhagic cystitis in cancer patients [show details]
…genes encoding proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin 11 (IL-11) . The end result is cessation of protein production and damage to the integrity of the urothelium … aminocaproic acid is administered intravesically as 200 mg of aminocaproic acid per 1 L of normal saline,… under low pressure (<15 cm H₂O), and with a short dwell time (10 to 15 minutes) .…