English Journal

An integrated approach with experimental and computational tools outlining the cooperative binding between 2-phenylchromone and human serum albumin.

Caruso ÍP1, Barbosa Filho JM2, de Araújo AS3, de Souza FP4, Fossey MA5, Cornélio ML6.
Food chemistry.Food Chem.2016 Apr 1;196:935-42. doi: 10.1016/j.foodchem.2015.10.027. Epub 2015 Oct 9.
2-Phenylchromone (2PHE) is a flavone, found in cereals and herbs, indispensable in the human diet. Its chemical structure is the basis of all flavonoids present in black and green tea, soybean, red fruits and so on. Although offering such nutritional value, it still requires a molecular approach to
PMID 26593575

Synthesis and anticonvulsant activity of certain substituted furochromone, benzofuran and flavone derivatives.

Ragab FA1, El-Sayed NA, Eissa AA, El Kerdawy AM.
Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).2010 Sep;58(9):1148-56.
Synthesis of furochromone, 2-phenylchromone (flavone) and benzofuran derivatives substituted with thiosemicarbazide or thiazolidin-4-one moieties were accomplished. All the newly synthesized compounds were tested for their anticonvulsant activity in both subcutaneous pentylenetetrazole induced seizu
PMID 20823592

Antimicrobial and cytotoxicity activities of the medicinal plant Primula macrophylla.

Najmus-Saqib Q1, Alam F, Ahmad M.
Journal of enzyme inhibition and medicinal chemistry.J Enzyme Inhib Med Chem.2009 Jun;24(3):697-701. doi: 10.1080/14756360802333406.
Primula macrophylla (Primulaceae) is reported as to be useful in asthma, restlessness, insomnia and fish poisoning. Antifungal and toxic activities of crude extract, fractions and a pure isolated compound exhibited statistically significant activities. Excellent antifungal activity was found in the
PMID 18686139

Japanese Journal

Synthesis and Anticonvulsant Activity of Certain Substituted Furochromone, Benzofuran and Flavone Derivatives

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Chemical and Pharmaceutical Bulletin 58(9), 1148-1156, 2010
… Synthesis of furochromone, 2-phenylchromone (flavone) and benzofuran derivatives substituted with thiosemicarbazide or thiazolidin-4-one moieties were accomplished. … The most active compounds in scPTZ model were 1c, 2b, 5a and 7e showing 100% protection at 300 mg/kg upon intraperitoneal administration. … Also, the effect of pre-treatment of three of the most active compounds (1c, 2b, 5a) on 4-amino pyridine-induced lethality in mice was investigated. …
NAID 130000324587

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