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1. 陣痛誘発前に未成熟な頸管を熟化させる手技 techniques for ripening the unfavorable cervix prior to induction
2. 妊娠中絶：妊娠第二期 termination of pregnancy second trimester
3. 早産児における動脈管開存症のマネージメント management of patent ductus arteriosus in premature infants
4. 早産児における動脈管開存症の病態生理、臨床症状、および診断 pathophysiology clinical manifestations and diagnosis of patent ductus arteriosus in premature infants
5. 動脈管開存症のマネージメント management of patent ductus arteriosus

Immunological tolerance in a mouse model of immune-mediated liver injury induced by 16,16 dimethyl PGE2 and PGE2-containing nanoscale hydrogels.

Okamoto T, Saito T, Tabata Y, Uemoto S.SourceDepartment of Surgery Hepato-pancreatico-biliary and Transplantation, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Biomaterials.Biomaterials.2011 Jul;32(21):4925-35. Epub 2011 Apr 8.
Although immunosuppressive agents play a pivotal role in the success of organ transplantation, chronic toxicity has been a major issue for long-term treatment. The development of therapies that induce donor-specific immunological tolerance remains an important clinical challenge. In the present stud
PMID 21477856

cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A.

Roscioni SS, Dekkers BG, Prins AG, Menzen MH, Meurs H, Schmidt M, Maarsingh H.SourceDepartment of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands. s.s.roscioni@rug.nl
British journal of pharmacology.Br J Pharmacol.2011 Jan;162(1):193-209. doi: 10.1111/j.1476-5381.2010.01011.x.
BACKGROUND AND PURPOSE: Changes in airway smooth muscle (ASM) phenotype may contribute to the pathogenesis of airway disease. Platelet-derived growth factor (PDGF) switches ASM from a contractile to a proliferative, hypo-contractile phenotype, a process requiring activation of extracellular signal-r
PMID 20804494

Nitric Oxide Donating Compounds Inhibit HCl-Induced Gastric Mucosal Lesions Mainly via Prostaglandin

UCHIDA Masayuki,MATSUEDA Kei,SHODA Ryosuke,MURAOKA Akira,YAMATO Shigeru
The Japanese journal of pharmacology 85(2), 133-138, 2001-02-01
… 16,16-Dimethyl PGE2 (0.3 - 3 μg/kg, p.o.; … dim-PGE2), sodium nitrite (0.3 and 1 mg/kg, s.c.) and sodium nitroprusside (30 and 100 μg/kg, i.v.; … The gastroprotective action by dim-PGE2 was not affected by the pre-treatment with NG-nitro-L-arginine methylester (10 mg/kg, i.v.). …
NAID 10007119811

A new method of separation and quantitation of mucus glycoprotein in rat gastric mucus gel layer and its application to mucus secretion induced by 16, 16-dimethyl PGE_2