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1. 妊娠中の喘息の管理 management of asthma during pregnancy
2. 喘息の治療において5-リポキシゲナーゼ経路に影響する薬剤 agents affecting the 5 lipoxygenase pathway in the treatment of asthma
3. 炎症性腸疾患治療におけるスルファサラジンおよび5-アミノサリチル酸の薬理学および
作用機序 pharmacology and mechanisms of action of sulfasalazine and 5 aminosalicylates in the treatment of inflammatory bowel disease
4. 関節リウマチの病因 pathogenesis of rheumatoid arthritis
5. ハーブ剤および栄養補助食品による肝毒性 hepatotoxicity due to herbal medications and dietary supplements

English Journal

Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.

Eleftheriadis N1, Poelman H1, Leus NG1, Honrath B2, Neochoritis CG3, Dolga A4, Dömling A3, Dekker FJ5.
European journal of medicinal chemistry.Eur J Med Chem.2016 Oct 21;122:786-801. doi: 10.1016/j.ejmech.2016.07.010. Epub 2016 Jul 9.
The enzyme 15-lipoxygenase-1 (15-LOX-1) plays a dual role in diseases with an inflammatory component. On one hand 15-LOX-1 plays a role in pro-inflammatory gene expression and on the other hand it has been shown to be involved in central nervous system (CNS) disorders by its ability to mediate oxida
PMID 27477687

8-Farnesyloxycoumarin induces apoptosis in PC-3 prostate cancer cells by inhibition of 15-lipoxygenase-1 enzymatic activity.

Hosseinymehr M1, Matin MM, Sadeghian H, Bahrami AR, Kaseb-Mojaver N.
Anti-cancer drugs.Anticancer Drugs.2016 Oct;27(9):854-62. doi: 10.1097/CAD.0000000000000399.
Prostate cancer is the second most common cancer in men worldwide. Overexpression of 15-lipoxygenase-1 (15-LOX-1) has been reported in prostate cancer patients. This study aimed to investigate the cytotoxic and anticancer effects of 8-farnesyloxycoumarin (8f), a prenylated coumarin, by inhibition of
PMID 27362790

Estradiol-17β increases 12- and 15-lipoxygenase (type2) expression and activity and reactive oxygen species in human umbilical vascular smooth muscle cells.

Somjen D1, Kohen F2, Limor R3, Sharon O3, Knoll E3, Many A3, Stern N3.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Oct;163:28-34. doi: 10.1016/j.jsbmb.2016.03.032. Epub 2016 Mar 28.
The net vascular effect of estrogens on the vasculature is still under debate. Here we tested the effects of estradiol- 17β (E2) as well as estrogen-receptor subtype specific and non-specific agonists and antagonists on the expression and eicosanoid production of lipoxygenase (LO) enzymes expressed
PMID 27033413