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English Journal

Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.

Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA.Source*Department of Anesthesiology, †Department of Chemistry and Biochemistry, and ‡Department of Pharmacology, University of California-San Diego, La Jolla, California, USA.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2013 Feb 4. [Epub ahead of print]
Previously, we observed significant increases in spinal 12-lipoxygenase (LOX) metabolites, in particular, hepoxilins, which contribute to peripheral inflammation-induced tactile allodynia. However, the enzymatic sources of hepoxilin synthase (HXS) activity in rats remain elusive. Therefore, we overe
PMID 23382512

Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.

Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K.SourceNeuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2013 Feb;27(2):437-45. doi: 10.1096/fj.12-206896. Epub 2012 Oct 15.
Recovery from stroke is limited, in part, by an inhibitory environment in the postischemic brain, but factors preventing successful remodeling are not well known. Using cultured cortical neurons from mice, brain endothelial cells, and a mouse model of ischemic stroke, we show that signaling from the
PMID 23070608

20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel.

Wen H, Östman J, Bubb KJ, Panayiotou C, Priestley JV, Baker MD, Ahluwalia A.SourceWilliam Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.
The Journal of biological chemistry.J Biol Chem.2012 Apr 20;287(17):13868-76. doi: 10.1074/jbc.M111.334896. Epub 2012 Mar 2.
TRPV1 is a member of the transient receptor potential ion channel family and is gated by capsaicin, the pungent component of chili pepper. It is expressed predominantly in small diameter peripheral nerve fibers and is activated by noxious temperatures >42 °C. 20-Hydroxyeicosatetraenoic acid (20-
PMID 22389490

越智宏
Memoirs of the Faculty of Integrated Arts and Sciences, Hiroshima University. IV, Science reports : studies of fundamental and environmental sciences 18, 111-113, 1992-12-31
… 種々のアラキドン酸代謝物の内皮細胞障害作用について調べたところ, ほとんどのアラキドン酸代謝物は細胞障害作用を示さなかったが, リポキシゲナーゼ代謝物の一つである15-ビドロペルオキシエイコサテトラエン酸(15-HPETE)が極めて強力な内皮細胞障害作用を示すことを見い出した。 … この15-HPETEによる内皮細胞障害作用は時間, 濃度および温度依存性を示した。 …
NAID 110000482172

三田晴久,油井泰雄,谷口昇,安枝浩,信太隆夫
アレルギー 35(1), 6-14, 1986-01-30
… メーターで測定した.健常者群と比較し, 喘息患者の血小板の12-HETEの生成量は有意に多く(p<0.01), 一方, TxB_2の生成量は有意に少なかった(p<0.01).HHTの生成量は両群で有意差はなかった.リポキシゲナーゼ系の代謝物に対するシクロオキシゲナーゼ系の代謝物(TxB_2とHHTの合計量)の比率は, 健常者群で3.48±1.22, 喘息群で2.19±1.27であった(p<0.02).12-HETEの生成量はシクロオキシゲナーゼ系の代謝物の生成量と …
NAID 110002414768