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English Journal

Synthesis of a novel class of substituted benzothiophene or benzofuran derivatives as BMP-2 up-regulators and evaluation of the BMP-2-up-regulating effects in vitro and the effects on glucocorticoid-induced osteoporosis in rats.

Xue ST1, Guo HF1, Liu MJ2, Jin J1, Ju DH2, Liu ZY3, Li ZR4.
European journal of medicinal chemistry.Eur J Med Chem.2015 May 26;96:151-61. doi: 10.1016/j.ejmech.2015.04.016. Epub 2015 Apr 8.
The BMP pathway is a promising new target for the design of therapeutic agents for the treatment of low bone mass. To enrich our understanding of SAR and based on our previously concluded structure-effect relationship, 23 derivatives were prepared in this work. The synthesis, up-regulating activitie
PMID 25874339

Hagino H1.
Canadian journal of physiology and pharmacology.Can J Physiol Pharmacol.2015 May;93(5):327-32. doi: 10.1139/cjpp-2014-0419. Epub 2015 Jan 28.
Vitamin D supplementation is recommended whenever patients are given therapeutic drugs for osteoporosis, to make their calcium (Ca) balance positive. Vitamin D is converted to 25-hydroxyvitamin D in the liver, and then activated to become 1α,25-dihydroxyvitamin D in the kidneys. The active vitamin
PMID 25853632

Effect of Alfacalcidol on multiple sclerosis-related fatigue: A randomized, double-blind placebo-controlled study.

Achiron A1, Givon U2, Magalashvili D2, Dolev M2, Liraz Zaltzman S2, Kalron A2, Stern Y2, Mazor Z3, Ladkani D3, Barak Y2.
Multiple sclerosis (Houndmills, Basingstoke, England).Mult Scler.2015 May;21(6):767-75. doi: 10.1177/1352458514554053. Epub 2014 Oct 24.
CONTEXT: Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS); however, there is no medication that has been approved specifically to treat MS-related fatigue.OBJECTIVE: We aimed to evaluate the effect of vitamin D analogue, Alfacalcidol, on MS-related fatigue.DESIGN,
PMID 25344375